NSC-12155
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- CAS-Nr.
- Englisch Name:
- NSC-12155
- Synonyma:
- NSC-12155;Aminokinuride;Surfen hydrate;Aminoquincarbamide;N,N′-Bis(4-amino-2-methyl-6-quinolyl)urea;N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea;1,3-Bis(2-methyl-4-aminoquinoline-6-yl)urea;1,3-Bis(4-amino-2-methyl-6-quinolyl)urea hydrate;(bis-2-methyl-4-amino-quinolyl-6-carbamide hydrate
- CBNumber:
- CB22378200
- Summenformel:
- Molgewicht:
- 0
- MOL-Datei:
- Mol file
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NSC-12155 Eigenschaften
- storage temp.
- 2-8°C
- Aggregatzustand
- powder
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H413 |
Kann für Wasserorganismen schädlich sein, mit langfristiger Wirkung. |
Langfristig (chronisch) gewässergefährdend |
Kategorie 4 |
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| Sicherheit |
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NSC-12155 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Surfen hydrate may be used as an antagonist to heparin.
Surfen hydrate has been used in the inhibition of multiple voltage-gated calcium channels in human embryonic kidney cells.
Biochem/physiol Actions
Surfen is a heparan sulfate antagonist, originally developed in the late thirties as an excipient for the production of depot insulin. Heparan sulfate (HS) is structurally related to heparin but contains fewer sulfate groups per disaccharide, and it exists almost exclusively attached to protein cores of proteoglycans, which cells either display on the plasma membrane or secrete into the extracellular matrix. Surfen binds to the chains of glycosaminoglycan (GAG)/HS and prevents binding of the enzymes and proteins thus act as HS antagonist. Surfen is more potent than protamine, a clinically used heparin antagonist.
NSC-12155 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
NSC-12155 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 2)Lieferanten
- 1,3-Bis(2-methyl-4-aminoquinoline-6-yl)urea
- N,N'-Bis(4-amino-2-methyl-6-quinolinyl)urea
- NSC-12155
- (bis-2-methyl-4-amino-quinolyl-6-carbamide hydrate
- 1,3-Bis(4-amino-2-methyl-6-quinolyl)urea hydrate
- Aminokinuride
- Aminoquincarbamide
- N,N′-Bis(4-amino-2-methyl-6-quinolyl)urea
- Surfen hydrate
