Fenbufen
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- CAS-Nr.
- 36330-85-5
- Bezeichnung:
- Fenbufen
- Englisch Name:
- Fenbufen
- Synonyma:
- bufemid;cl82204;napanol;cinopal;Cinopol;enbufen;lederfen;FENBUFEN;Fenbufen CRS;FENBUFENTABLETS
- CBNumber:
- CB2239125
- Summenformel:
- C16H14O3
- Molgewicht:
- 254.29
- MOL-Datei:
- 36330-85-5.mol
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Fenbufen Eigenschaften
- Schmelzpunkt:
- 184-187 °C (lit.)
- Siedepunkt:
- 357.5°C (rough estimate)
- Dichte
- 1.1565 (rough estimate)
- Brechungsindex
- 1.5600 (estimate)
- storage temp.
- 2-8°C
- Löslichkeit
- Very slightly soluble in water, slightly soluble in acetone, in ethanol (96 per cent) and in methylene chloride.
- pka
- pKa 4.3(H2O tunde?ned Iunde?ned) (Uncertain)
- Wasserlöslichkeit
- 2.212mg/L(25 ºC)
- Merck
- 13,3990
- EPA chemische Informationen
- [1,1'-Biphenyl]-4-butanoic acid, .gamma.-oxo- (36330-85-5)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
T |
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| R-Sätze: |
25 |
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| S-Sätze: |
28-45 |
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| RIDADR |
UN 2811 6.1/PG 3 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
DV1761000 |
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| HazardClass |
6.1 |
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| PackingGroup |
III |
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| HS Code |
2918300090 |
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| Toxizität |
LD50 in various strains of mice, rats (mg/kg): 795-1673, 200-720 orally; 506-811, 265-575 i.p. (Bolte) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
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Fenbufen Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Fenbufen has been found to be an effective, well-tolerated drug for the treatment of
rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Fenbufen is prepared by the Friedel-Crafts (aluminum chloride – nitrobenzene)
acylation of biphenyl with succinic anhydride. The compound is metabolized
in humans first to 4-hydroxy-4-biphenylbutyric
acid (tmax 2.5 h) then to 4-biphenyl acetic acid
(tmax 7.5 h). Both metabolites are more active
than fenbufen itself and circulate for several
hours (t1/2 10 h). This slow conversion of fenbufen to active metabolites having relatively
long plasma half-lives allows for once a day dosing with this agent.
Chemische Eigenschaften
White Solid
Verwenden
Cyclo-oxygenase inhibitor; analgesic; anti-inflammatory
Allgemeine Beschreibung
Fenbufen belongs to the class of non-steroidal anti-inflammatory drugs, widely used as an antipyretic and analgesic in medical applications. Its mode of action involves the inhibition of cyclooxygenase enzyme and thereby prevents the synthesis of certain prostaglandins.
Sicherheitsprofil
Poison by ingestion,intraperitoneal, and subcutaneous routes. Human systemiceffects by ingestion: cough, sweating, body temperature.An experimental teratogen. Other experimentalreproductive effects. An anti-inflammatory agent. Whenheated to decomposi
Fenbufen Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Fenbufen Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 242)Lieferanten
36330-85-5(Fenbufen)Verwandte Suche:
- FENBUFEN
- GAMMA-OXO-[1,1'-BIPHENYL]-4-BUTANOIC ACID
- GAMMA-OXO(1,1'-BIPHENYL)-BUTANOIC ACID
- 4-(4-BIPHENYL)-4-OXOBUTYRIC ACID
- 4-(4-BIPHENYLYL)-4-OXOBUTYRIC ACID
- 3-(4-PHENYLBENZOYL)PROPIONIC ACID
- cl82204
- diphenyl-4-gamma-oxo-gamma-butyricacid
- lederfen
- napanol
- [1,1'-Biphenyl]-4-butanoic acid, γ-oxo
- 1’-biphenyl)-4-butanoicacid,gamma-oxo-(
- 3-(4-biphenylylcarbonyl)-propionicaci
- 3-(4-biphenylylcarbonyl)propionicacid
- beta,p-phenylbenzoylpropionicacid
- butyricacid4-(4-biphenyl)-4-oxo-
- cinopal
- 3-[4-Biphenylcarbonyl] propionic acid
- γ-oxo-(1,1'-biphenyl)-4-butanoic acid
- diphenyl acetoacetate
- gamma-oxo-(1'-biphenyl)-4-butanoic acid
- [1,1'-biphenyl]-4-butanoic Acid.
- 4-(Biphenyl-4-yl)-4-oxobutanoic Acid
- Cinopol
- γ-Oxo[1,1'-biphenyl]-4-butyric acid
- 3-(4-Phenylbenzoyl)propionic
- 4-(4-Phenylphenyl)-4-oxobutyric acid
- enbufen
- Fenchlorphos`Fenbufen
- JRH-05504, 3-(4-Phenyl)benzoyl propionic acid, 97%
- Fenbufen,Sulindac,Naproxen,Probenecid
- FENBUFENTABLETS
- Fenbufen CRS
- Pyrido[2,3-d]pyrimidine-6-carboxylicacid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-piperazinyl)-, hydrate (1:3)
- Fenbufen USP/EP/BP
- bufemid
- Finn cloth Finn
- 3-(p-phenyl)benzoylpropionic acid
- 4-([1,1'-Biphenyl]-4-yl)-4-oxobutanoic acid
- 36330-85-5
- C6H5C6H4COCH22CO2H
- 25428
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