IM-12
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- CAS-Nr.
- 1129669-05-1
- Englisch Name:
- IM-12
- Synonyma:
- IM-12;CS-2144;CS-1819;IM-12 USP/EP/BP;The GSK3β Inhibitor XIX;THE GSK3Β INHIBITOR XIX; IM 12; IM-12;IM12;3-(4-fluorophenethylaMino)-1-Methyl-4-(2-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;Glycogen synthase kinase-3,Glycogen synthase kinase 3,IM12,Inhibitor,inhibit,IM-12,GSK-3;3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
- CBNumber:
- CB22716259
- Summenformel:
- C22H20FN3O2
- Molgewicht:
- 377.41
- MOL-Datei:
- 1129669-05-1.mol
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IM-12 Eigenschaften
- Schmelzpunkt:
- 187 °C
- Siedepunkt:
- 600.2±55.0 °C(Predicted)
- Dichte
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- Löslichkeit
- DMSO: ≥9mg/mL
- Aggregatzustand
- powder
- pka
- 16.77±0.30(Predicted)
- Farbe
- yellow-orange
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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IM-12 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Glycogen synthase kinase 3β (GSK3β) is a constitutively active serine/threonine protein kinase implicated in several important regulatory processes. It can phosphorylate β-catenin, an intracellular signal transducer in the Wnt signaling pathway, which leads to β-catenin degradation. IM-12 is a non-symmetrically substituted indolylmaleimide that increases β-catenin levels by inhibiting GSK3β (IC
50 = 53 nM). It has been shown to reduce proliferation and increase differentiation of a ReNCell VM cell line derived from human ventral midbrain. IM-12 is also reported to have a depolymerizing effect on
in vitro tubulin assembly.
Verwenden
3-((4-Fluorophenethyl)amino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione acts as an enhancer of Wnt signalling, involved in cell proliferation or differentiation, via inhibition of glycogen synthase kinase 3 beta (GSK-3β).
IM-12 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
IM-12 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 87)Lieferanten
- IM-12
- 3-(4-fluorophenethylaMino)-1-Methyl-4-(2-Methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
- 3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
- 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione IM-12
- 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
- CS-1819
- CS-2144
- The GSK3β Inhibitor XIX
- THE GSK3Β INHIBITOR XIX; IM 12; IM-12;IM12
- 1H-Pyrrole-2,5-dione, 3-[[2-(4-fluorophenyl)ethyl]amino]-1-methyl-4-(2-methyl-1H-indol-3-yl)-
- IM-12 USP/EP/BP
- Glycogen synthase kinase-3,Glycogen synthase kinase 3,IM12,Inhibitor,inhibit,IM-12,GSK-3
- 1129669-05-1
- 129669-05-1
- Inhibitors
