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Lithocholsure Produkt Beschreibung

NCI-C03861;NCI-CO-3861;Lithocholate;Lithocolic acid;LITHOCHOLIC ACID;Lithocholic aCld;Stone cholic acid;Lithocholic Acide;HYDROYCHOLANIC ACID;Lithocholic acid,98%
Lithocholsure physikalisch-chemischer Eigenschaften
Schmelzpunkt:: 183-188 °C(lit.)
alpha : D20 +33.7° (c = 1.5 in abs ethanol); D19 +23.3° (Wieland); D20 +32.1° (Fischer)
Siedepunkt:: 445.09°C (rough estimate)
Dichte: 1.0454 (rough estimate)
Brechungsindex: 35.5 ° (C=1, EtOH)
Flammpunkt:: 9℃
storage temp. : Refrigerator
Aggregatzustand: Powder
Farbe: White to off-white
Merck : 5545
BRN : 3217757
CAS Datenbank: 434-13-9(CAS DataBase Reference)
S-Sätze:: 22-24/25
RIDADR : UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany : 2
RTECS-Nr.: FZ2275000
HS Code : 29181998

Lithocholsure Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white to off-white powder
A cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones.
LD50(mouse) 3900 mg/kg po
ChEBI: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Allgemeine Beschreibung
Hexagonal leaflets (from alcohols) or prisms (from acetic acid) or white powder.
Air & Water Reaktionen
Insoluble in water.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition LITHOCHOLIC ACID emits acrid smoke and fumes.
Flash point data for LITHOCHOLIC ACID are not available. LITHOCHOLIC ACID is probably combustible.
läuterung methode
Lithocholic acid can be purified by conversion to the rather insoluble Na or K salt by addition of the equivalent amount of aqueous NaOH or KOH, filtering off the alkali salt, washing it with ice cold H2O, dissolving it in the least volume of boiling H2O, acidifying with the dilute HCl (slight excess), filtering off the acid, washing with cold H2O and drying it thoroughly in a vacuum. Recrystallise it from Me2CO, EtOH or acetic acid. The methyl ester crystallises from MeOH, with 0.5 mol of MeOH, and has m 92-93o, [] D 25 +34o (MeOH). It has also been purified by recrystallisation from pet ether (b 40-60o) and, after chromatography on Al2O3 in pet ether, gave a labile form m 92-93o which is transformed to the stable form m 125-126o after standing for 2days in a vacuum desiccator. [Hoelm & Mason J Am Chem Soc 62 569 1940, Sarel & Yanuka J Org Chem 24 2018 1959, Beilstein 10 IV 785.]
Lithocholsure Upstream-Materialien And Downstream Produkte
Downstream Produkte
Lithocholsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 148)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259 CHINA 3210 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 22064 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20743 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32606 55
Chemwill Asia Co.,Ltd.
86-21-51086038;;; CHINA 24093 58
(323) 306-3136
(626) United States 8416 58
career henan chemical co
+86-371-86658258 CHINA 19975 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038 CHINA 3623 58
Wuhan Netcom Electronic Commerce Limited 18029749525 China 5141 58
Shanghai QianJin Chemical Technology Co., Ltd 021-20900665,17321230821 China 1691 55
434-13-9(Lithocholsure)Verwandte Suche:
Cholsure Cholan-24-sure Natrium-2-[[(3α,5β,12α)-3,12-dihydroxy-24-oxocholan-24-yl]amino]ethan-1-sulfonat 3-α,6-α-Dihydroxy-5-β-cholan-24-sure Methylcholat Methyllithocholat 3α,6α,7α-Trihydroxy-5β-cholan-24-sure Natriumcholat Natriumdesoxycholat Methyl-3-α,12-α-dihydroxy-5-β-cholan-24-oat Lithocholsure Ursodeoxycholsure
Lithocolic acid NCI-C03861 3α-Hydroxy-5β-cholan-24-oic acid 3α-Hydroxy-5β-cholanic acid 5β-Cholan-24-oic acid-3α-ol (4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,] LITHOCHOLIC ACID(RG) 3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol 3β-Hydroxyallocholanic acid NCI-CO-3861 Lithocholic acid,98% Lithocholic acid3alpha-Hydroxycholanic acid 3-HYDROXYCHOLANIC ACID 3ALPHA-HYDROXYCHOLANIC ACID 3ALPHA-HYDROXY-5BETA-CHOLANIC ACID 3ALPHA-HYDROXY-5BETA-CHOLAN-24-OIC ACID 5BETA-CHOLAN-24-OIC ACID-3A-OL 5BETA-CHOLAN-24-OIC ACID-3ALPHA-OL 5BETA-CHOLANIC ACID-3ALPHA-OL LITHOCHOLIC ACID Lithocholic Acide Lithocholic acid,3α-Hydroxy-5β-cholan-24-oic acid, 3α-Hydroxy-5β-cholanic acid, 5β-Cholan-24-oic acid-3α-ol 17β-(1-Methyl-3-car-boxypropyl) etiocholan-3α-ol Lithocholic acid, 98% 5GR (3α,5β)-3-Hydroxycholan-24-oic Acid 3α-Hydroxy-5β-cholan-24-oate 3α-Hydroxy-5β-cholanoic Acid 5beta-Cholanic Acid-3alpha-ol 3alpha-Hydroxy-5beta-cholanic Acid BETA-CHOLANIC ACID-3-ALPHA-OL HYDROYCHOLANIC ACID 17-beta-(1-Methyl-3-carboxypropyl)ethiocholan-3-alpha-ol 17beta-(1-methyl-3-carboxypropyl)etiocholan-3alpha-ol Sterols Lipids Bile acids and Derivatives BioChemical Biochemicals and Reagents Bile Acids 434-13-9 C24H40O3 3-alpha-hydroxy-5-beta-cholan-24-oicaci 3alpha-hydroxy-5beta-cholan-24-oicaci 3-alpha-hydroxy-5-beta-cholanicaci 3alpha-Hydroxy-5beta-cholanoic acid 3alpha-hydroxy-5beta-cholanoicacid 3-hydroxy-,(3-alpha,5-beta)-cholan-24-oicaci 3-hydroxy-,(3alpha,5beta)-cholan-24-oicaci 3-Hydroxycholan-24-oic acid 3-hydroxycholan-24-oicacid 5beta-Cholan-24-oic acid, 3alpha-hydroxy- 5-beta-Cholanic acid, 3-alpha-hydroxy- Cholan-24-oic acid, 3-hydroxy-, (3alpha,5beta)- Lithocholate Cholan-24-oic acid, 3-hydroxy-, (3α,5β)- Lithocholic aCld LITHOCHOLIC ACID >=95% Ursodeoxycholic Acid EP Impurity C Stone cholic acid
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