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Vinflunine

Vinflunine Struktur
162652-95-1
CAS-Nr.
162652-95-1
Englisch Name:
Vinflunine
Synonyma:
VINFLUNINE;vinflunine（97%）;Vinflunine Tartrate;Vinflunine (F12158);Vinflunine USP/EP/BP;Vinflunine 162652-95-1;20',20'-Difluoro-3',4'-dihydrovinorelbine;4'-Deoxy-20',20'-difluoro-8'-norvincaleukoblastine;4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine;Aspidospermidine-3-carboxylicacid,4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-1
CBNumber:
CB2358406
Summenformel:
C45H54F2N4O8
Molgewicht:
816.94
MOL-Datei:
162652-95-1.mol
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Vinflunine Eigenschaften

Dichte
1.39±0.1 g/cm3(Predicted)
pka
11.36±0.60(Predicted)
CAS Datenbank
162652-95-1(CAS DataBase Reference)

Sicherheit

Vinflunine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Vinflunine (also referred to as PM391) is a semisynthetic analog of the natural vinca alkaloids vinblastine and vincristine that was approved by the European Medicines Agency (EMEA) in 2009 for the treatment of adult patients with advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of a prior platinum-containing regimen. Vinflunine is synthesized from anhydrovinblastine in a superacid media (HF-SbF5) and in the presence of a chlorinated solvent like CHCl3 or CCl4.

Definition

ChEBI: An organic heteropentacyclic compound and an organic heterotetracyclic compound that is vinorelbine in which the tetrahydropyridine moiety of the heterotetracyclic part of the molecule has been redced to the corresponding piperidine, and in which the ethy group attached to this ring has been replaced by a 1,1-difluoroethyl group.

Vinflunine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Vinorelbine

Downstream Produkte

Vinflunine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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162652-95-1()Verwandte Suche:

L-2-Hydroxy-4-methylvaleriansure 3,3,5,5-Tetramethylcyclohexanol 4-Phenylcyclohexan-1-ol N,N,2,2,4,4-Hexamethylpentylamin
  • VINFLUNINE
  • 20',20'-Difluoro-3',4'-dihydrovinorelbine
  • 4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine
  • 4'-Deoxy-20',20'-difluoro-8'-norvincaleukoblastine
  • Vinflunine Tartrate
  • Vinflunine 162652-95-1
  • Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-
  • Vinflunine USP/EP/BP
  • Vinflunine (F12158)
  • Aspidospermidine-3-carboxylicacid,4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-1
  • vinflunine（97%）
  • Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)-
  • 162652-95-1
  • C45H54F2N4O8
  • Miscellaneous Natural Products
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