Indapamid

Indapamide Struktur
26807-65-8
CAS-Nr.
26807-65-8
Bezeichnung:
Indapamid
Englisch Name:
Indapamide
Synonyma:
INDAPAMID;indaflex;Idapamide;ndapamide;N-(4-CHLORO-3-SULFAMOYLBENZAMIDO)-2-METHYLINDOLINE;4-chloro-N-[(2S)-2-Methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfaMoylbenzaMide;s1520;lozol;tandix;damide
CBNumber:
CB2420420
Summenformel:
C16H16ClN3O3S
Molgewicht:
365.83
MOL-Datei:
26807-65-8.mol

Indapamid Eigenschaften

Schmelzpunkt:
160-162°C
Siedepunkt:
110.4°C (rough estimate)
alpha 
-0.8~+0.8°(D/20℃) (c=5, C2H5OH)
Dichte
1.2895 (rough estimate)
Brechungsindex
1.6100 (estimate)
storage temp. 
-20°C Freezer
Löslichkeit
Practically insoluble in water, soluble in ethanol (96 per cent).
pka
pKa (25°) 8.8 ± 0.2
Farbe
White to Off-White
Wasserlöslichkeit
Soluble in ethanol. Insoluble in water
Merck 
14,4935
BCS Class
1
InChIKey
NDDAHWYSQHTHNT-UHFFFAOYSA-N
CAS Datenbank
26807-65-8(CAS DataBase Reference)
EPA chemische Informationen
Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)- (26807-65-8)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
WGK Germany  2
RTECS-Nr. CV2451200
HS Code  2935904000
Toxizität LD50 in rats, mice, guinea pigs (mg/kg): 393-421, 410-564, 347-416 i.p.; 394-440, 577-635, 272-358 i.v.; >3000 all species orally (Kyncl)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H362 Kann Säuglinge über die Muttermilch schädigen. Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P263 Kontakt während der Schwangerschaft /und der Stillzeit vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

Indapamid Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Indapamide is a derivative of benzolsulfonamide and its mechanism of action is analogous to that of thiazides. It is intended for lowering arterial blood pressure and as an adjuvant drug for treating edema caused by cardiac insufficiency.

Chemische Eigenschaften

Crystalline Solid

Definition

ChEBI: A sulfonamide formed by condensation of the carboxylic group of 4-chloro-3-sulfamoylbenzoic acid with the amino group of 2-methyl-2,3-dihydro-1H-indol-1-amine.

Clinical Use

Indapamide is an effective diuretic drug when GFR falls below 40 mL/min. The duration of action is approximately 24 hours, with the normal oral adult dosage starting at 2.5 mg given each morning. The dose may be increased to 5.0 mg/day, but doses beyond this level do not appear to provide additional results.

Nebenwirkungen

Effects on urine content and side effects are similar to effects induced by thiazide diuretics.

Indapamid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Indapamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 447)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
shandong perfect biotechnology co.ltd
+86-53169958659; +8618596095638
sales@sdperfect.com China 294 58
Hebei Guanlang Biotechnology Co,.LTD
+8619930503252
daisy@crovellbio.com China 5964 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21691 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075
jack.li@time-chemicals.com China 1807 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714
fandachem@gmail.com China 9348 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3620 58
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
Casorganics US Corp
+17326109938
sales@casorganics.com CHINA 174 58

26807-65-8(Indapamid)Verwandte Suche:


  • N-[4-CHLORO-3-SULFAMOYL-BENZAMIDOL]-2-METHYLINDOLINE
  • INDAPAMIDE
  • 3-(aminosulfonyl)-4-chloro-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)-benzamid
  • 3-(aminosulfonyl)-4-chloro-n-(2,3-dihydro-2-methyl-1h-indol-1-yl)benzamide
  • 4-chloro-n-(2-methyl-1-indolinyl)-3-sulfamoyl-benzamid
  • natrilix
  • noranat
  • s1520
  • se-1520
  • tandix
  • IndapaMide(Lozol)
  • IndapaMide API
  • indaparnide
  • 1-(4-chloro-3-sulfamoylbenzamido)-2-methylindoline
  • 4-chloro-n-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide
  • bajaten
  • damide
  • fludex
  • indamol
  • ipamix
  • lozol
  • IndapamideC16H16C1N303S
  • 4-Chloro-N-(2-methyl-1-indolymyl)-3-sulfamolybenzamide
  • Arifon
  • Flubest
  • Idamide
  • rac Indapamide
  • Veroxil
  • Benzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-
  • INDAPAMIDE USP
  • Benzamide, 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl- (8CI)
  • Fludin
  • Flupamid
  • Indamide
  • Racemic indapamide
  • Tertensif
  • Indapamidum
  • Benzamide, 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoyl-
  • Lonzol
  • Cormil
  • Indapamide (250 mg)
  • 1-(4-CHLORO-3-SULFAMOYLBENAZMIDO)-2-METHYL INDOLINE
  • Levetiracetam Solution, 100ppm
  • 3-(aminosulfonyl)-4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)benzamide
  • Indapamide RS
  • Indapamide, racemic mixture
  • Indapamide CRS
  • Indapamide USP/EP/BP
  • 4-chloro-N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3- sulfamoylbenzamide
  • Indapamide(I0150000)Q: What is Indapamide(I0150000) Q: What is the CAS Number of Indapamide(I0150000)
  • IndapamideQ: What is Indapamide Q: What is the CAS Number of Indapamide Q: What is the storage condition of Indapamide Q: What are the applications of Indapamide
  • Indapamide 13C D3Q: What is Indapamide 13C D3 Q: What is the CAS Number of Indapamide 13C D3 Q: What is the storage condition of Indapamide 13C D3 Q: What are the applications of Indapamide 13C D3
  • (R)-1-"3 , 5-bis(trifluoromethyl)phenyl”ethanol ,TFM
  • indaflex
  • Idapamide
  • INDAPAMID
  • ndapamide
  • 4-chloro-N-[(2S)-2-Methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfaMoylbenzaMide
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