Nonactin
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- CAS-Nr.
- 6833-84-7
- Bezeichnung:
- Nonactin
- Englisch Name:
- NONACTIN
- Synonyma:
- 3584-a;a-5584;e-79-c;n-329-a;NONACTIN;ta-25-m-i;fh-3582-a;POLYNACTIN;WERRAMYCIN A;AMMONIUM IONOPHORE
- CBNumber:
- CB2424675
- Summenformel:
- C40H64O12
- Molgewicht:
- 736.93
- MOL-Datei:
- 6833-84-7.mol
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Nonactin Eigenschaften
- Schmelzpunkt:
- 147-148°
- Siedepunkt:
- 890.6±65.0 °C(Predicted)
- Dichte
- 1.11-1.15 g/cm3
- storage temp.
- 2-8°C
- Löslichkeit
- chloroform: soluble10mg/mL
- Aggregatzustand
- White to off-white crystalline solid.
- Farbe
- white to faint yellow
- Sensitive
- Moisture Sensitive
- Merck
- 13,6709
- BRN
- 76434
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Nonactin Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Light yellow powder
Verwenden
Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purified to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium.
Biologische Aktivität
Monovalent cation ionophore that displays selectivity for K + and NH 4 + (K + = NH 4 + > Na + > Mg 2+ > Li + >> Ca 2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.
läuterung methode
This macrotetrolide antibiotic crystallises from MeOH as colourless needles and is dried at 90o/20hours/high vacuum. [Cordaz et al. Helv Chim Acta 38 1445 1955, crystal structure: Dobler Helv Chim Acta 55 1371 1972, Gambos et al. Tetrahedron Lett 3391 1975, Beilstein 19/12 V 751.]
Nonactin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Nonactin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 113)Lieferanten
6833-84-7(Nonactin)Verwandte Suche:
- ta-25-m-i
- NONACTIN
- NONACTIN, STREPTOMYCES GRISEUS
- POLYNACTIN
- NONACTIN FROM STREPTOMYCES GRISEUS
- NONACTINE, FROM STREPTOMYCES SP.
- NONACTIN FROM STREPTOMYCES TSUSIMAENSIS
- nonactinfromstreptomycessp.
- NONACTINE, STREPTOMYCES GRISEUS
- Nonactin, Amonium Ionophore, Werramycin A, Polynactin
- Ammonium ionophore, Nonactin
- (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-Octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
- WerraMycin, FH 3582A, NSC 52141, AKD 1A, KD 1A
- Nonactin /
5342 Pfw 19 / A 4426 / Ammonium ionophore I
- Nonactin from Streptomyces griseus var griseus
- AMMONIUM IONOPHORE
- AMMONIUM IONOPHORE I
- WERRAMYCIN A
- -(1r*,2r*,5r*,7r*,10s*,11s*,14s*,16s*,19r*,20r*,23r*,25r*,28s*,29s*,32s*,34s*)
- 28))tetracontane-3,12,21,30-tetrone,2,5,11,14,20,23,29,32-octamethyl-2(1r
- 3584-a
- 4,13,22,31,37,38,39,40-octaoxapentacyclo(32.2.1.1(sup7,10).1(sup16,19).1(sup
- a-5584
- e-79-c
- fh-3582-a
- n-329-a
- 4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-
- NONACTIN USP/EP/BP
- Nonactin (Mixture contains Monactin and Dinactin) (Technical Grade)
- Nonactin, Monactin, and Dinactin Mixture
- 6833-84-7
- C40H64O12
- Antibiotics A to Z
- Antibiotics N-S
- Antibiotics
- Ionophores Potentiometric for ISE
- Ion Sensor Materials
- BioChemical
- Analytical Chromatography Product Catalog
- inhibitor
