3-α-Hydroxy-7-oxo-5-β-cholan-24-sure
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- CAS-Nr.
- 4651-67-6
- Bezeichnung:
- 3-α-Hydroxy-7-oxo-5-β-cholan-24-sure
- Englisch Name:
- 3alpha-Hydroxy-7-oxo-5beta-cholanic Acid
- Synonyma:
- 7-KETOLITHOCHOLIC ACID;Nutriacholic acid;7-Oxolithocholic acid;3α-Hydroxy-7-oxo-5β-cholan-24-oic acid;3α-Hydroxy-7-ketocholanic acid;Chenodeoxycholic acid EP Impurity F;3ALPHA-HYDROXY-7-KETO-5BETA-CHOLANIC ACID;(R)-4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-diMethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;OCA-A;Nsc226118
- CBNumber:
- CB2430908
- Summenformel:
- C24H38O4
- Molgewicht:
- 390.56
- MOL-Datei:
- 4651-67-6.mol
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3-α-Hydroxy-7-oxo-5-β-cholan-24-sure Eigenschaften
- Schmelzpunkt:
- 205°C
- Siedepunkt:
- 545.9±25.0 °C(Predicted)
- Dichte
- 1.124±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- Dioxane (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 4.76±0.10(Predicted)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Wasserlöslichkeit
- 2.062mg/L at 25℃
- InChIKey
- DXOCDBGWDZAYRQ-QHVQYUNXNA-N
- SMILES
- C(O)(=O)CC[C@H]([C@@H]1[C@@]2(C)CC[C@]3([H])[C@@]4(C)CC[C@@H](O)C[C@@]4([H])CC(=O)[C@@]3([H])[C@]2([H])CC1)C |&1:5,6,7,11,13,17,20,25,27,r|
- LogP
- 3.48 at 20℃
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P302+P352 |
BEI BERÜHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckmäßig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P321 |
Besondere Behandlung |
| P330 |
Mund ausspülen. |
| P332+P313 |
Bei Hautreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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3-α-Hydroxy-7-oxo-5-β-cholan-24-sure Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
Nutriacholic Acid (Ursodeoxycholic Acid EP Impurity F) is derivative of Lithocholic Acid (L469180), a cholic acid derivative as TGR5 modulator.
Verwenden
3alpha-Hydroxy-7-oxo-5beta-cholanic Acid is an intermediate in organic synthesis and pharmaceutical research and development. It can be used to synthesize the choleretic drug Obeticholic acid. Obeticholic acid can inhibit cholic acid synthesis. It is commonly used to treat primary biliary cirrhosis and nonalcoholic fatty liver disease.
Definition
ChEBI: 7-oxolithocholic acid is a bile acid that is lithocholic acid carrying an additional oxo substituent at position 7. It has a role as a human metabolite. It is a bile acid, a monohydroxy-5beta-cholanic acid, an oxo-5beta-cholanic acid and a 3alpha-hydroxy steroid. It is functionally related to a lithocholic acid. It is a conjugate acid of a 7-oxolithocholate.
3-α-Hydroxy-7-oxo-5-β-cholan-24-sure Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-α-Hydroxy-7-oxo-5-β-cholan-24-sure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 332)Lieferanten
4651-67-6(3-α-Hydroxy-7-oxo-5-β-cholan-24-sure)Verwandte Suche:
- 3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID
- 5-BETA-CHOLANIC ACID-3-ALPHA-OL-7-ONE
- 3alpha-Hydroxy-7-oxo-5?cholanic acid
- 3-alpha-hydroxy-7-oxo-5-beta-cholan-24-oic acid
- Hydroxycholanicacid
- 4-(3-hydroxy-10,13-dimethyl-7-oxo-1,2,3,4,5,6,8,9,11,12,14,15,16,17-tetrade cahydrocyclopenta[a]phenanthren-17-yl)pentanoic acid
- ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID
- alpha-Hydroxy-7-oxo-5beta-cholic acid
- 3-ALPHA-HYDROXY-7-OXO-5-BETA-CHOLANOICACID
- 3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID 97+%
- Cholan-24-oic acid, 3-hydroxy-7-oxo-, (3.alpha.,5.beta.)-
- Nsc226118
- 3-Hydoxy-7-ketocholanic acid
- 3α-Hydroxy-7-oxo-5β-cholanic acid
- 7-Ketochenodeoxycholic acid
- 7-Oxo-3α-hydroxy-5β-cholan-24-oic acid
- 3-Hydroxy-7-oxocholan-24-oic acid
- 3a-Hydroxy-7-oxo-5b-cholanic acid
- 3alpha-Hydroxy-7-oxo-5beta-cholic acid
- (3α,5β)-3-Hydroxy-7-oxo-Cholan-24-oic acid
- Cholan-24-oic acid,6-ethyl-3,7-dihydroxy-,(3α,5β,6β,7β)-
- 3-alpha-hydroxy-7-oxo-5-beta-cholan-24-oic
- obeticholic acid intermediate 1
- 3α-Hydroxy-7-keto-5β-cholanic Acid
- 3Α--hydroxy-7-oxo -5Β- bile acid
- OCA-A
- 3ɑ-Hydroxy-7-Oxo-5β-Cholanic Acid
- 3ALFA-HYDROXI-7KETO-5BETA-CHOLAN-24-ACID
- 3α-Hydroxy-7-oxo-5β-cholic acid
- 7-Ketolithocholic acid (3alpha-hydroxy-7-oxo-5beta-Cholanic acid)
- ursodeoxycholic acid oxide
- Ursodeoxycholic Acid EP Impurity F(7-Ketolithocholic Acid)
- Ursodeoxycholic Acid Impurity 6（Ursodeoxycholic Acid EP Impurity F）
- 3α-hydroxy-7-oxo-5β-cholanoic acid
- 3α-Hydroxy-7-oxo-5b-cholanic acid, 98%
- Chenodeoxycholic Acid Impurity 6
- Ursodeoxycholic Acid EP Impurity F
- 3α-Hydroxy-7-oxo-5β-cholanicAcid>
- 5β-CHOLANIC acid-3α-OL-7-ONE
- Cholan-24-oic acid, 3-hydroxy-7-oxo-, (3α,5β)-
- Emtricitabine Impurity 33
- 7-oxolithocholicaci
- 3ALPHA-HYDROXY-7-OXO-5BETA-CHOLANIC ACID USP/EP/BP
- Chenodeoxycholic Acid Impurity 6(Chenodeoxycholic Acid EP Impurity F)
- 3α-Hydroxy-7-keto-5β-cholanic Acid
- Chenodeoxycholic Acid EP Impurity F (Ursodeoxycholic Acid EP Impurity F/ 7-Oxo Ursodeoxycholic Acid/ 7-Oxo Chenodeoxycholic Acid)
- Ursodeoxycholic Acid EP Impurity F (Chenodeoxycholic Acid EP Impurity F/ 7-Oxo Ursodeoxycholic Acid/ 7-Oxo Chenodeoxycholic Acid)
- Ursodiol Impurity F
- 3α-Hydroxy-7-oxo-5β-cholanic acid
- Ursodeoxycholic Acid EP Impurity F,3α-hydroxy-7-oxo-5β-cholan-24-oic acid
- 7-KETOLITHOCHOLIC ACID
- 3ALPHA-HYDROXY-7-KETO-5BETA-CHOLANIC ACID
- Nutriacholic acid
- 3α-Hydroxy-7-oxo-5β-cholan-24-oic acid
- 7-Oxolithocholic acid
- (R)-4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-diMethyl-7-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
- 3α-Hydroxy-7-ketocholanic acid
- Chenodeoxycholic acid EP Impurity F
