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Hyoscinmethylnitrat Produkt Beschreibung

SCOPOLAMINE METHYL NITRATE Struktur
6106-46-3
CAS-Nr.
6106-46-3
Bezeichnung:
Hyoscinmethylnitrat
Englisch Name:
SCOPOLAMINE METHYL NITRATE
Synonyma:
skopyl;viscope;mescomine;skopolate;itrate,(-)-tropate;HYOSCINEMETHONITRATE;dwithmethylnitrate1:1);HYOSCINE METHYL NITRATE;METHSCOPOLAMINE NITRATE;METHYL HYOSCINE NITRATE
CBNumber:
CB2453455
Summenformel:
C18H24N2O7
Molgewicht:
380.39
MOL-Datei:
6106-46-3.mol

Hyoscinmethylnitrat Eigenschaften

Schmelzpunkt:
199 °C
Brechungsindex
-25 ° (C=1, H2O)
Merck 
14,8406
CAS Datenbank
6106-46-3(CAS DataBase Reference)
EPA chemische Informationen
Methylscopolamine nitrate (6106-46-3)

Sicherheit

Kennzeichnung gefährlicher T,T+
R-Sätze: 23/24/25-26/27/28
S-Sätze: 36/37/39-45-25
RIDADR  UN 1544 6.1/PG 3
WGK Germany  3
RTECS-Nr. YM3675150
HazardClass  6.1
PackingGroup  III
Giftige Stoffe Daten 6106-46-3(Hazardous Substances Data)

Hyoscinmethylnitrat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S25:Berührung mit den Augen vermeiden.

Originator

Transderm ,Scop Novartis Consumer Health Inc.

Manufacturing Process

In a one-liter separatory funnel, 94 g (0.215 mol) of scopolamine hydrobromide trihydrate was dissolved in 250 ml of water, made alkaline by shaking with 40 g (1 mol) of sodium hydroxide in 150 ml of water, and the free base immediately extracted with ether. As scopolamine is somewhat soluble in water, the aqueous layer was saturated with potassium carbonate and again extracted with ether. The combined ether extracts were dried over anhydrous magnesium sulfate and the ether removed by distillation, leaving 65 g (0.214 mol; 100% yield) of nearly colorless oil. Then 100 g (1.05 mol) of cold methyl bromide was added to a chilled, 500-ml pressure flask containing the 65 g of scopolamine, the flask stoppered tightly with a clamp, and allowed to stand at room temperature for 96 hours. The flask was cooled before opening, excess methyl bromide removed by distilling, and the white solid washed thoroughly with dry ether. The yield of crude Nmethylscopolammonium bromide was 80 g (94 %t yield). The salt was recrystallized from 550 ml of alcohol; first crop, 70 g, MP: 212-214°C; second crop, 6 g, melting point 195-200°C. The combined crops were again recrystallized from 500 ml of alcohol; melting point 210-212°C. The third recrystallization from 600 ml of alcohol yielded 64 g, melting point 214- 216°C, a 75 % yield based on scopolamine hydro-bromide trihydrate starting material. N-Methylscopolammonium bromide may be dissolved in water. An equivalent of solution AgNO3 was added, a precipitated AgBr was filtered off. The filtrate was evaporated to dryness to give the desired Nmethylscopolammonium nitrate.

Trademarks

Mesconit;Skopyle.

Therapeutic Function

Anticholinergic, Spasmolytic

Weltgesundheitsorganisation (WHO)

Hyoscine methonitrate, a quaternary ammonium anticholinergic agent, was introduced in 1947 for use as a gastrointestinal antispasmodic. The action taken in Sweden relates to the use of this compound in preparations for suppressing the appetite. Preparations may remain available elsewhere.

Hyoscinmethylnitrat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Hyoscinmethylnitrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 60)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21031 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Antai Fine Chemical Technology Co.,Limited
18503026267
info@antaichem.com CHINA 9664 58
Career Henan Chemica Co
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0371-86658258 Laboratory@coreychem.com CHINA 30281 58
AFINE CHEMICALS LIMITED
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+86-0592-6210733 sale@mainchem.com CHINA 32439 55
J & K SCIENTIFIC LTD. 400-666-7788 010-82848833-
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 400-660-8290 21-61259100-
86-21-61259102 sh@meryer.com China 40264 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 821-50328103-801
86-21-50328109 3bsc@sina.com China 15877 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24555 81

6106-46-3(Hyoscinmethylnitrat)Verwandte Suche:


  • (-)SCOPOLAMINE METHYL NITRATE
  • SCOPOLAMINE METHYL NITRATE
  • METHSCOPOLAMINE NITRATE
  • HYOSCINE METHYL NITRATE
  • ,9-dimethyl-,[7(s)-(1alpha,2beta,4beta,5alpha,7beta)]-,nitrate(salt)
  • 1alphah,5alphah-tropanium,6beta,7beta-epoxy-3alpha-hydroxy-8-methyl-,nitrate,
  • 4)non-7-ylester,(7(s)-(1alpha,2beta,4beta,5alpha,7beta))-.0comp
  • 5-alpha-h-tropanium,6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-1-alpha-n
  • 9-dimethyl--(7(s)-(1alpha,2beta,4beta,5alpha,7beta))--nitrate(salt)
  • alpha,-(hydroxymethyl)-benzeneaceticaci9-methyl-3-oxa-9-aztricyclo(3.3.1
  • dwithmethylnitrate1:1)
  • epoxytropinetropatemethylnitrate
  • itrate,(-)-tropate
  • mescomine
  • methylnitrate,compdwithscopolamine
  • methylscopolaminenitrate
  • n-methylscopolammoniumnitrate
  • scopolamine,compdwithmethylnitrate(1:1)
  • skopolate
  • skopyl
  • viscope
  • HYOSCINEMETHONITRATE
  • (-)-Scopolaminmethylnitrat
  • (-)-N-methylhyoscinium nitrate
  • Hyoscine methyl nitrate, Methscopolamine nitrate
  • METHYL HYOSCINE NITRATE
  • Scopolamine Methyl Nitrate >
  • (-)Scopolamine Methylnitrate
  • 6106-46-3
  • C17H21NO4CH3NO3
  • C18H24N2O7
  • C18H24NO4NO3
  • Tropane Alkaloids
  • Alkaloids
  • Alkaloids
  • Biochemistry
  • Tropane Alkaloids
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