Geldanamycin-Biotin

1320265-38-0

CAS-Nr.: 1320265-38-0

Englisch Name:: Geldanamycin-Biotin

Synonyma:: Geldanamycin-Biotin;4,7,10,13-Tetraoxa-16-azaheneicosanamide, N-[2-[2-[2-[[(8S,9S,12S,13R,14S,16R)-9-[(aminocarbonyl)oxy]-13-hydroxy-8,14-dimethoxy-4,12,16-trimethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaen-19-yl]amino]ethoxy]ethoxy]ethyl]-21-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-...

CBNumber:: CB24669988

Summenformel:: C54H85N7O17S

Molgewicht:: 1136.37

MOL-Datei:: 1320265-38-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 2

Geldanamycin-Biotin Eigenschaften

Siedepunkt:: 1275.6±65.0 °C(Predicted)

Dichte: 1.28±0.1 g/cm3(Predicted)

storage temp.: -20°C

Löslichkeit: Soluble in DMSO (up to 10 mg/ml)

pka: 8.60±0.70(Predicted)

Aggregatzustand: powder

Farbe: Purple

Stabilität:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

WGK Germany	3

Geldanamycin-Biotin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Geldanamycin-biotin is a biotinylated ligand for affinity purification of HSP-90 and HSP-90-dependent proteins.

Biochem/physiol Actions

Geldanamycin-Biotin is a benzoquinone ansamycin antitumor antibiotic. Geldanamycin binds specifically to Hsp90 (HeatShock Protein 90). and to its endoplasmic reticulum homologue GP96. The Hsp90 chaperone is required for the activation of several families of eukaryotic protein kinases and nuclear hormone receptors, many of which are proto-oncogenic and play a prominent role in cancer. The geldanamycin antibiotic has antiproliferative and antitumor effects, as it binds to Hsp90, inhibits the HSP90-mediated conformational maturation/refolding reaction, and results in the degradation of Hsp90 substrates. Hsp90 also plays a key role in regulating the physiology of cells exposed to environmental stress and thus, geldanamycin interferes with cellular stess response.

Geldanamycin-Biotin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Geldanamycin-Biotin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 2)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

Geldanamycin-Biotin
4,7,10,13-Tetraoxa-16-azaheneicosanamide, N-[2-[2-[2-[[(8S,9S,12S,13R,14S,16R)-9-[(aminocarbonyl)oxy]-13-hydroxy-8,14-dimethoxy-4,12,16-trimethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaen-19-yl]amino]ethoxy]ethoxy]ethyl]-21-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-...
1320265-38-0
C54H85N7O17S