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7(S),18(R)-Dihydroxy-16(S),18-dimethyl-10-phenyl[11]cytochalasa-6(12),13(E),19(E)-trien-1,17-dion-21(R)-acetat Produkt Beschreibung

CYTOCHALASIN D Struktur
22144-77-0
CAS-Nr.
22144-77-0
Bezeichnung:
7(S),18(R)-Dihydroxy-16(S),18-dimethyl-10-phenyl[11]cytochalasa-6(12),13(E),19(E)-trien-1,17-dion-21(R)-acetat
Englisch Name:
CYTOCHALASIN D
Synonyma:
Nsc209835;ZYGOSPORIN A;Lygosporin a;Cytohalasin d;CYTOCHALACIND;CYTOCHALICIND;CYTOCHALASIN D;19-trien-17-one;CYTOCHALASIN D(RG);InSolution? Cytochalasin D,
CBNumber:
CB2672937
Summenformel:
C30H37NO6
Molgewicht:
507.62
MOL-Datei:
22144-77-0.mol

7(S),18(R)-Dihydroxy-16(S),18-dimethyl-10-phenyl[11]cytochalasa-6(12),13(E),19(E)-trien-1,17-dion-21(R)-acetat Eigenschaften

Schmelzpunkt:
255-260°C
Siedepunkt:
595.84°C (rough estimate)
Dichte
1.1764 (rough estimate)
Brechungsindex
1.6310 (estimate)
Flammpunkt:
87℃
storage temp. 
−20°C
Löslichkeit
DMSO: soluble
Aggregatzustand
White solid
pka
11.95±0.70(Predicted)
BRN 
1632828
EPA chemische Informationen
Cytochalasin D (22144-77-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T
R-Sätze: 25-63
S-Sätze: 36/37-45
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
RTECS-Nr. GZ4850000
HazardClass  6.1(a)
PackingGroup  I
HS Code  29337900
Giftige Stoffe Daten 22144-77-0(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizität oral Kategorie 2 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H361 Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Reproduktionstoxizität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P281 Vorgeschriebene persönliche Schutzausrüstung verwenden.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

7(S),18(R)-Dihydroxy-16(S),18-dimethyl-10-phenyl[11]cytochalasa-6(12),13(E),19(E)-trien-1,17-dion-21(R)-acetat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R25:Giftig beim Verschlucken.
R63:Kann das Kind im Mutterleib möglicherweise schädigen.

S-Sätze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Chemische Eigenschaften

Powder

Verwenden

Cytochalasin D acts as an anti-hypertensive drug acting on human intestinal epithelial caco-2 cells. Also has activity in HMG-CoA reductase inhibitors used in the lowering of cholesterol. Actin inhib itor, actin polymerization inhibitor affecting cell movement, growth, phagocytosis and even secretion.

Verwenden

Cytochalasin D is the most studied of the cytochalasins. Like most of the members of this mycotoxin class, cytochalasin D exhibits potent inhibition of actin filament function leading to cell death by apoptosis. This led to early investigation of the metabolite as an antitumour agent. Cytochalasin D has become one of the standard cellular probes for investigating the role of actin in cell biology.

Verwenden

A cell cycle arresting compound used in actin polymerization studies and cytological research

Definition

ChEBI: An organic heterotricyclic compound that is a mycotoxin produced by Helminthosporium and other moulds which is cell permeable and a potent inhibitor of actin polymerisation and DNA synthesis.

Allgemeine Beschreibung

Needles or fluffy white powder.

Reaktivität anzeigen

CYTOCHALASIN D may be sensitive to exposure to heat. CYTOCHALASIN D can react with strong oxidizing agents, strong acids and strong bases. .

Brandgefahr

Flash point data for CYTOCHALASIN D are not available; however, CYTOCHALASIN D is probably combustible.

Biologische Aktivität

Potent disruptor of actin filament function. Alters tight junction permeability. Unlike cytochalasin B, does not inhibit monosaccharide transport across the plasma membrane.

Sicherheitsprofil

Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

7(S),18(R)-Dihydroxy-16(S),18-dimethyl-10-phenyl[11]cytochalasa-6(12),13(E),19(E)-trien-1,17-dion-21(R)-acetat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


7(S),18(R)-Dihydroxy-16(S),18-dimethyl-10-phenyl[11]cytochalasa-6(12),13(E),19(E)-trien-1,17-dion-21(R)-acetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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22144-77-0(7(S),18(R)-Dihydroxy-16(S),18-dimethyl-10-phenyl[11]cytochalasa-6(12),13(E),19(E)-trien-1,17-dion-21(R)-acetat)Verwandte Suche:


  • CYTOCHALASIN D
  • CYTOCHALASIN D, ZYGOSPORIUM MANSONII
  • CYTOCHALASIN D, ZYGUSPORIUM MANSONII
  • (7S,13E,16S,18R,19E,21R)-21-(ACETYLOXY)-7,18-DIHYDROXY-16,18-DIMETHYL-10-PHENYL[11]CYTOCHALASA-6(12),13,19-TRIENE-1,17-DIONE
  • (11)cytochalasa-6(12),13,19-triene-1,17-dione,21-(acetyloxy)-7,18-dihydroxy-16
  • ,12,15-decahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-,15-acetate
  • ,18-dimethyl-10-phenyl-,(7s,13e,16s,18r,19e,21r)-
  • 15-decahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-115-acetate
  • 19-trien-17-one
  • 1h-cycloundec(d)isoindole-1,11(2h)-dione,3-benzyl-3,3-alpha,4,5,6,6-alpha,9,10
  • 1h-cycloundec(d)isoindole-1,11(2h)-dione,3-benzyl-3,3-alpha4,5,6,6-alpha,9,10,
  • 7,18-dihydroxy-10-phenyl-5,16,18-trimethyl-[11]cytochalas-21-acetoxy-6(12),13,
  • ZYGOSPORIN A
  • cytochalasin D from zygosporium masonii
  • 7(S),18(R)-dihydroxy-16(S),18-dimethyl-10-phenyl[11]cytochalasa-6(12),13(E),19(E)-triene-1,17-dione 21(R)-acetate
  • [11]Cytochalasa-6(12),13,19-triene-1,17-dione, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E,21R)-
  • [11]Cytochalasa-6[12],13,19-triene-1,17-dione, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-
  • 1H-Cycloundec[D]isoindole-1,11(2H)-dione, 3-benzyl-3,3-.alpha.,4,5,6,6-.alpha.,9,10,12,15-decahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-, 15-acetate
  • Cytohalasin d
  • Lygosporin a
  • Nsc209835
  • 1H-Cycloundecdisoindole-1,11(2H)-dione, 15-(acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-, (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-
  • CYTOCHALASIN D(RG)
  • CYTOCHALACIND
  • CYTOCHALICIND
  • Cytochalasin D, Zygosporin A
  • CYTOCHALASIN D FROM ZYGOSPORIUMMANSONII
  • InSolution? Cytochalasin D,
  • Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem
  • InSolution Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem
  • 22144-77-0
  • BioChemical
  • Antibiotics
  • Antibiotics A to Z
  • Antibiotics A-F
  • antibiotic
  • Caspases/Apoptosis
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