(R)-(+)-2-Methyl-2-propanesulfinamide
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- CAS-Nr.
- 196929-78-9
- Englisch Name:
- (R)-(+)-2-Methyl-2-propanesulfinamide
- Synonyma:
- (R)-2-METHYLPROPANE-2-SULFINAMIDE;(R)-TERT-BUTANESULFINAMIDE;(R)-2-METHYL-2-PROPANESULFINAMIDE;Trityl glycidyl ether;(R)-N-tert-Butanesulfinamide;DASO-002;Borax LR;R-(+)-TBSA;-2-propanesuL;Nicotinamide Impurity 18
- CBNumber:
- CB2765464
- Summenformel:
- C4H11NOS
- Molgewicht:
- 121.2
- MOL-Datei:
- 196929-78-9.mol
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(R)-(+)-2-Methyl-2-propanesulfinamide Eigenschaften
- Schmelzpunkt:
- 103-107 °C(lit.)
- Siedepunkt:
- 220.0±23.0 °C(Predicted)
- alpha
- 4 º (c=1, CHCl3 + amylenes)
- Dichte
- 0.903 g/mL at 25 °C
- Brechungsindex
- 4 ° (C=1, CHCl3)
- Flammpunkt:
- -17℃
- storage temp.
- 2-8°C
- Löslichkeit
- Soluble in chloroform, methanol, tetrahydrofuran, dichloromethane, dimethyl sulfoxide and most organic solvents.
- Aggregatzustand
- Powder
- pka
- 10.11±0.50(Predicted)
- Farbe
- White, light pink, light yellow to brown
- Optische Aktivität
- [α]22/D +1.0°, c = 0.5% in chloroform
- Stabilität:
- store cold
- InChIKey
- CESUXLKAADQNTB-SSDOTTSWSA-N
- CAS Datenbank
- 196929-78-9(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
  
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS02.jpg" width="20" height="20" /> |
P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P210 |
Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P370+P378 |
Bei Brand: zum Löschen verwenden. |
| P403+P235 |
An einem gut belüfteten Ort aufbewahren. Kühl halten. |
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(R)-(+)-2-Methyl-2-propanesulfinamide Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
(R)-(+)-2-Methyl-2-propanesulfinamide is white to light yellow crystal powde
Verwenden
(R)-(+)-2-Methyl-2-propanesulfinamide is a chiral ligand, which is used in pharmaceutical compositions. Further, it is used in the preparation of beta-chloro sulfinamides in the synthesis of chiral azridines. It is involved in the preparation of organocatalyst for enantioselective reduction of imines. It serves as a reagent for synthesizing chiral amines. In addition to this, it is converted into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones which undergoes iridium-catalyzed asymmetric hydrogenation of olefins.
synthetische
Acetic acid (70 g), R-tert-butylsulfinylhydrazine (42 g), zinc powder (60.5 g) and dichloromethane (150 mL) were added to the reaction flask. The temperature was slowly heated to 35-42 °C . After 16 hours, the filtrate was poured into 70 mL water. Dichloromethane (75 g×5) was added for extraction. Collected the organic phase, added 48% NaOH to adjust ρΗ (7-8). Then added NaCl, the layers were separated and the organic phase was washed with 15 g saturated aqueous solution of sodium chloride. The solution was dried over magnesium sulfate. After filterED, filtrate was concentrated under reduced pressure at 25-30 °C until no slipping. N-heptane was replaced, 28 g mixed solvent of N-heptane and toluene (N-heptane: toluene = 6:1) were added to perform beating at low temperature, filtered to obtain (R)-(+)-2-Methyl-2-propanesulfinamide. Yield=83%
Einzelnachweise
[1] Qian X, et al. A stereoselective synthesis of (S)-2-(((3-fluoro-4-methylphenoxy)carbonyl)(1-(4-((5-methyl-2-phenyloxazol-4-yl)methoxy)phenyl)ethyl)amino)acetic acid, a highly potent PPAR α/γ dual agonist. Tetrahedron, 2015; 71: 9408-9414.
(R)-(+)-2-Methyl-2-propanesulfinamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(R)-(+)-2-Methyl-2-propanesulfinamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 464)Lieferanten
196929-78-9()Verwandte Suche:
- R- tert butyl sulfenaMide
- (R)-(+)-TERT-BUTANESULFINAMIDE
- (R)-(+)-T-BUTANESULFINAMIDE
- (R)-(+)-T-BUTYLMETHYLSULFINAMIDE
- (R)-(+)-T-BUTYLSULFINAMIDE
- (R)-(+)-TERT-BUTYLSULFINAMIDE
- (R)-(+)-TERT-BUTYL SULPHINAMIDE
- (R)-(+)-2-METHYL-PROPANE-2-SULFINIC ACID AMIDE
- (R)-(+)-2-METHYL-2-PROPANESULFINAMIDE
- (R)- (+)- 2-Methyl-2-propanesulphinaMide
- (R)-(+)-2-Methyl-2-propanesulfinaMide / (R)-tert-ButanesulfinaMide
- (R)-(+)-2-Methyl-2-propanesulfinamide solution
- 2-Propanesulfinamide, 2-methyl-, [S(R)]-
- (R)-(+)-tert-Butylsulfinamide
- (R)-(+)-2-Methyl-2-propanesulfinaMide, 97+%
- (R)-(+)-2-Methyl-2-propanesulfinamide 98%
- (R)-(+)-2-Methyl-2-propanesulfinamide≥ 99% (HPLC, Chiral purity)
- (R)-2-Methyl-2-propanesulfinamide,99%e.e.
- (R)-TERT-BUTANESULFINAMIDE / (R)-(+)-2-METHYL-2-PROPANESULFINAMIDE
- (R)-(+)-2-METHYL-2-PROPANESULFINAMIDE, 98+%
- R-(+)-Tert-Butansulfinamide
- (R)-(+)-t-Butylmethylsulfinamide,min.97%
- (R)-(+)-tert-Butyl sulphinamide 98%
- (R)-(+)-t-Butyl sulfinamide, 98% ee
- (R)-(+)-2-Methylpropane-2-sulphinamide
- (R)-(+)-t-Butylmethylsulfinamide, min. 97%
- (R)-(+)-Methyl-2-propanesulfinamide
- (R)-(+)-2-Methylpropane-2-sulphinamide 98%
- R-(+)-TBSA
- (R)-(+)-t-Butylsulfinamide, min. 97%
- (R)-(+)-2-methyyl-2-propanesulfinamide
- DASO-002
- (R)-(+)-tert-Butylsulfinamide >
- -2-propanesuL
- (R)-(+) -tert-butylsulfonamide
- (R)-(+)-2-Methyl-2-propanesulfinamide USP/EP/BP
- (R)-(-)-2-Methyl-2-Propane sulfonamide
- (R)-TERT-BUTANESULFINAMIDE
- (R)-2-METHYLPROPANE-2-SULFINAMIDE
- (R)-2-METHYL-2-PROPANESULFINAMIDE
- Trityl glycidyl ether
- (R)-N-tert-Butanesulfinamide
- RSYY（Donepezil Hydrochloride)-8
- Nicotinamide Impurity 18
- Borax LR
- S-(tert-butyl) (R)-2-methylpropane-2-sulfinothioate
- 196929-78-9
- 1969-78-9
- 96929-78-9
- 3196929-78-9
- C6H19NOS
- C4H11OSN
- Chiral Auxiliaries
- Asymmetric Synthesis
- Sulfur-Based
- Synthetic Organic Chemistry
- CHIRAL CHEMICALS
- Sulfur Compounds
