Tandutinib

Tandutinib Struktur
387867-13-2
CAS-Nr.
387867-13-2
Englisch Name:
Tandutinib
Synonyma:
CS-309;MLN 518;CT 53518;NSC726292;Tandutinib;Unii-E1io3icj9a;CT53518; MLN518;Tandutinib(TINIBS);MLN518, Tandutinib;Tandutinib (MLN518)
CBNumber:
CB31011758
Summenformel:
C31H42N6O4
Molgewicht:
562.7
MOL-Datei:
387867-13-2.mol

Tandutinib Eigenschaften

Schmelzpunkt:
177-178°C
Siedepunkt:
769.5±60.0 °C(Predicted)
Dichte
1.213±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
Löslichkeit
Chloroform (Slightly), Methanol (Slightly)
pka
13.39±0.70(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White
CAS Datenbank
387867-13-2(CAS DataBase Reference)

Sicherheit

Tandutinib Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Tandutinib is a potent antagonist of platelet-derived growth factor receptor β (PDGFRβ), FLT3, and c-Kit (IC50 = 200, 220, and 170 nM, respectively). It less potently inhibits macrophage colony-stimulating factor 1 receptor (IC50 = 3.4 μM) and does not significantly inhibit other tyrosine or serine/threonine kinases. Tandutinib blocks the growth of cells expressing an internal tandem duplication within the juxtamembrane domain of the FLT3 receptor, found in some acute myelogenous leukemia cells. It also impairs the growth of colon cancer cells through its actions on the c-Kit receptor. Tandutinib reverses multidrug resistance in vitro by impairing the efflux activity of the multidrug resistance protein 7.

Chemische Eigenschaften

White Solid

Verwenden

An oral, small-molecule inhibitor of FLT3 for the treatment of AML (acute myelogenous leukemia) and other cancer indications. The drug exhibited limited activity as a single agent in phase I and II clinical trials in patients with AML and myelody

Definition

ChEBI: An N-arylpiperazine that is piperazine in which the hydrogen attached to the nitrogen at position 1 is replaced by a 6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl group, while the hydrogen attached to the nitrogen at position 4 s replaced by a (p-isopropoxyphenyl)aminocarbonyl group. Tandutinib is an inhibitor of tyrosine kinases FLT3, PDGFR and KIT.

Tandutinib Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Tandutinib Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 171)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806
sales@capotchem.com China 29797 60
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845
sales@amoychem.com China 6387 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22968 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47465 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29826 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17368 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23556 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29831 58

387867-13-2()Verwandte Suche:


  • Tandutinib
  • 1-Piperazinecarboxamide, 4-(6-methoxy-7-(3-(1-piperidinyl)propoxy)-4-quinazolinyl)-N-(4-(1-methylethoxy)phenyl)-
  • 4-(6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl)piperazine-1-carboxylic acid (4-isopropoxyphenyl)amide
  • Unii-E1io3icj9a
  • Tandutinib(CT 53518)
  • Tandutinib (MLN518)
  • CT53518; MLN518
  • Tandutinib(TINIBS)
  • (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide
  • 4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(4-propan-2-yloxyphenyl)piperazine-1-carboxamide
  • 4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamide
  • CT 53518
  • MLN 518
  • Tandutinib for research
  • N-(4-isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1-carboxamide
  • NSC726292
  • (4-(6-Methoxy-7-(3-piperidylpropoxy)quinazolin-4-yl)piperazinyl)-N-(4-(methylethoxy)phenyl)carboxamide Tandutinib(MLN518)
  • 4-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-Methylethoxy)phenyl]-
  • N-(4-Isopropoxyphenyl)-4-(6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-yl)piperazine-1-
  • MLN518; CT53518; MLN 518; CT 53518; MLN-518; CT-53518;
  • Tandutinib (CT53518, MLN518)
  • CS-309
  • Tandutinib(MLN518, CT53518)
  • Tandutinib USP/EP/BP
  • Tandutinib (MLN518, CT53518, NSC-726292)
  • 4-[6-Methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-yl]-N-(...
  • MLN518, Tandutinib
  • Tandutinib CT53518 MLN518 CT-53518 MLN-518
  • 387867-13-2
  • C31H42N6O4
  • C27H31Br2ClN4O2
  • Inhibitors
  • ZUBRIN
  • API
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Tyrosine Kinase Inhibitors
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