Alosetron hydrochloride
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- CAS-Nr.
- 122852-69-1
- Englisch Name:
- Alosetron hydrochloride
- Synonyma:
- Lotronex;ALOSETRON HCL;GR 68755;GR 68755C;GR 68755X;Alosetron hydrocloride;ALOSETRON HYDROCHLORIDE;Alosetron hydrochloride salt;Alosetron hydrochloride USP/EP/BP;Cc1[nH]cnc1CN2CCc4c(C2=O)c3ccccc3n4C.Cl
- CBNumber:
- CB3107074
- Summenformel:
- C17H19ClN4O
- Molgewicht:
- 330.81
- MOL-Datei:
- 122852-69-1.mol
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Alosetron hydrochloride Eigenschaften
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
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P264, P280, P305+P351+P338,P337+P313P |
| H412 |
Schädlich für Wasserorganismen, mit langfristiger Wirkung. |
Langfristig (chronisch) gewässergefährdend |
Kategorie 3 |
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P273, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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Alosetron hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Lotronex (alosetron) was developed for the treatment of severe
irritable bowel syndrome (IBS), and was approved for use by
the US Food and Drug Administration (FDA) in 2000.
Although Lotronex had a relatively high improvement rate in
patients taking the drug for IBS, it was voluntarily pulled from
the market by GlaxoWellcome that same year due to reports of
severe adverse side effects, some resulting in death.
In 2002, Lotronex was reapproved in a supplemental New
Drug Application for use under more restrictive conditions.
Now with a risk management program to be consulted prior to
administration of the drug, Lotronex is designated to be
prescribed only when its medical benefits outweigh the risks of
toxic effects; women with severe diarrhea-predominant IBS are
now the focal point of prescriptions for Lotronex.
Chemische Eigenschaften
Alosetron hydrochloride is Crystalline Solid
Verwenden
Alosetron hydrochloride is used in treatment of irritable bowel syndrome
Definition
ChEBI: The hydrochloride salt of alosetron.
Environmental Fate
The environmental fate and behavior of Lotronex is uncertain,
as formal studies regarding its release into the environment are
virtually nonexistent in the literature. Limited water solubility
(61 mg ml
-1) may lead to persistence in soils, and in sediment
following aquatic release, although specific fates with regard to
degradation, bioaccumulation, and transport are unknown.
Alosetron hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Alosetron hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 248)Lieferanten
122852-69-1()Verwandte Suche:
Kresoxim-methyl
Thiophanat-methyl
2,6-Dimethylpyridin
Azlocillin
Imidazol
Methylsalicylat
4-Methylpyridin
2-[[[[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester
ALOSETRON
Topotecan hydrochloride
Natrium-[2S-[2α,5α,6β(S*)]]-3,3-dimethyl-7-oxo-6-[[[[(2-oxoimidazolidin-1-yl)carbonyl]amino]phenylacetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylat
(3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one monohydrochloride
2-Chloro-5-chloromethylpyridine
Tribenuron methyl
Azamethiphos
2,4,6-Trimethylpyridin
Granisetron hydrochloride
Methylacetat
- 5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-3,4-dihydropyrido[4,3-b]indol-1-one hydrochloride
- GR 68755C
- 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1h-imidazol-4-yl)methyl]-1h-pyrido[4,3-b]indol-1-one hydrochloride
- ALOSETRON HYDROCHLORIDE
- 2,3,4,5-Tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-1H-pyrido[4,3-b]indol-1-one Hydrochloride
- GR 68755
- GR 68755X
- Alosetron hydrocloride
- 1H-Pyrido[4,3-b]indol-1-one,2,3,4,5-tetrahydro-5-methyl-2-[(4-methyl-1H-imidazol-5-yl)methyl]-,hydrochloride (1:1)
- 5-Methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one Hydrochloride
- Alosetron hydrochloride USP/EP/BP
- Alosetron hydrochlorideQ: What is
Alosetron hydrochloride Q: What is the CAS Number of
Alosetron hydrochloride Q: What is the storage condition of
Alosetron hydrochloride Q: What are the applications of
Alosetron hydrochloride
- ALOSETRON HCL
- Lotronex
- Cc1[nH]cnc1CN2CCc4c(C2=O)c3ccccc3n4C.Cl
- Alosetron hydrochloride salt
- AlosetronHydrochloride/GR68755Hydrochloride
- 5-Methyl-2-((4-methyl-1H-imidazol-5-yl)methyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one hydrochloride
- 122852-69-1
- C17H18N4OHCl
- C17H18ClN4O
- Inhibitors
- Active Pharmaceutical Ingredients
- Bases & Related Reagents
- Heterocycles
- Intermediates & Fine Chemicals
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