Cefatrizin

Cefatrizine Struktur
51627-14-6
CAS-Nr.
51627-14-6
Bezeichnung:
Cefatrizin
Englisch Name:
Cefatrizine
Synonyma:
s640p;bls640;SKF-60771;eta(r)))-;CEFATRIZINE;cephatriazine;Cephathiamidine;antibioticbl-640;CEPHATHIAMIDINUM;antibioticbl-s640
CBNumber:
CB3116636
Summenformel:
C18H18N6O5S2
Molgewicht:
462.5
MOL-Datei:
51627-14-6.mol

Cefatrizin Eigenschaften

Siedepunkt:
948.1±65.0 °C(Predicted)
Dichte
1.3806 (rough estimate)
Brechungsindex
1.7000 (estimate)
storage temp. 
Store at -20°C
Löslichkeit
DMSO: 95 mg/mL (201.02 mM);Ethanol: 23 mg/mL (48.67 mM)
pka
2?+-.0.50(Predicted)
Wasserlöslichkeit
Water: 95 mg/mL (201.02 mM)
CAS Datenbank
51627-14-6(CAS DataBase Reference)

Sicherheit

Toxizität LD50 in male, female mice, male, female rats (mg/kg): 6880, 6410, 4325, 4325 i.p. (Matsuzaki)

Cefatrizin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cefatrizine was synthesized by BristolMyers Co. and Smith Klein & French Laboratories in 1974. It shows two to four times higher activity against gram-positive and four to eight times higher activity against gram-negative bacteria than cephalexin. Cefatrizine also shows excellent oral absorption, and its in vivo activity is 30 to 500 times higher than that of cephalexin.

Verwenden

Cefatrizine is a new orally administered cephalosporin with excellent activity against gram-positive cocci, inhibiting all except enterococci at minimal inhibitory concentrations below 1 μg/ml.

Definition

ChEBI: A cephalosporin compound having (1H-1,2,3-triazol-4-ylsulfanyl)methyl and [(2R)-2-amino-2-(4-hydroxyphenyl)]acetamido side-groups. An antibacterial drug first prepared in the 1970s, it has more recently been found to be n inhibitor of eukaryotic elongation factor-2 kinase (eEF2K), which is known to regulate apoptosis, autophagy and ER stress in many types of human cancers.

Antimicrobial activity

A semisynthetic cephalosporin formulated for oral use. The spectrum is similar to that of cefalexin but it is more active against H. influenzae. Wide strain variations in susceptibility have been reported.
It is only partially absorbed when given by mouth. A 500 mg oral dose achieves a concentration of c. 6 mg/L after 1–2 h. The normal half-life of 2.5 h is extended to 5.5 h in end-stage renal failure. Distribution resembles that of cefalexin. It crosses the placenta readily. Plasma protein binding is 40–60%.
Urinary recovery in 6 h is 35% of an oral dose, producing urinary levels of 50–1500 mg/L. It is presumed that the remainder is metabolized, but no metabolites have been identified.
Apart from some mild diarrhea, it is well tolerated. It is available in Japan.

Sicherheitsprofil

Moderately toxic byintraperitoneal and subcutaneous routes. An experimentalteratogen. Other experimental reproductive effects. Whenheated to decomposition it emits very highly toxic fumesof NOx and SOx.

Cefatrizin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Cefatrizin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 114)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845
sales@amoychem.com China 6387 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47465 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29826 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17368 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671
sales@tnjchem.com China 34572 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 9802 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29831 58
Finetech Industry Limited
+86-27-87465837 +8618971612321
info@finetechnology-ind.com China 9589 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616
gksales1@gk-bio.com China 9340 58

51627-14-6(Cefatrizin)Verwandte Suche:


  • CEFATRIZINE
  • CEFATRIZINE PROPYLENE GLYCOL
  • 7-[2-(4-hydroxyphenyl)-2-aminoacetamido]-3-(1,2,3-triazole-4-ylthio)methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • antibioticbl-640
  • antibioticbl-s640
  • bls640
  • cephatriazine
  • eta(r)))-
  • l)acetyl)amino)-8-oxo-3-((1h-1,2,3-triazol-4-ylthio)methyl)-,(6r-(6-alpha,7-b
  • s640p
  • SKF-60771
  • Cephathiamidine
  • CEFATRIZINE IMPURITY A7-AMINO-(6R,7R)-3-[(2H-1,2,3-TRIAZOL-4-YL)SULFANYL]-METHYL-8-OXO-5-THIA-1-AZABICYCLO[4.2.O]OCT-2-ENE-2-CARBOXYLIC ACID(7-ACA TRIAZOLE) EPC(CRM STANDARD)
  • CEPHATHIAMIDINUM
  • (6R,7R)-7-[[2-amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-(2H-triazol-4-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2R)-2-aMino-2-(4-hydroxyphenyl)acetyl]aMino]-8-oxo-3-[(1H-1,2,3-triazol-5-ylthio)Methyl]-,(6R,7R)-
  • Cefatrizine USP/EP/BP
  • 51627-14-6
  • 57627-40-2
  • 330175-00-2
  • C19H28N4O6S2
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