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2,2-bis(4-fluorophenyl)-2-phenyl-acetamide

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Struktur
289656-45-7
CAS-Nr.
289656-45-7
Englisch Name:
2,2-bis(4-fluorophenyl)-2-phenyl-acetamide
Synonyma:
Senicapoc;ICA 17043;Senicapoc (ICA17043);ICA-17043;ICA 17043;ICA17043;2,2-bis(4-fluorophenyl)-2-phenyl-acetamide;4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide;Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-;Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-;4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide
CBNumber:
CB31261049
Summenformel:
C20H15F2NO
Molgewicht:
323.34
MOL-Datei:
289656-45-7.mol
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2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Eigenschaften

Schmelzpunkt:
180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2))
Siedepunkt:
460.7±45.0 °C(Predicted)
Dichte
1.250±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
Löslichkeit
DMSO : 50 mg/mL (154.64 mM; Need ultrasonic)
Aggregatzustand
Powder
pka
15.41±0.50(Predicted)

Sicherheit

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (; IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per day) reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3+ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; ) and ionomycin (Item Nos. 10004974 | 11932) when used at a concentration of 1 μM. Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve.

Verwenden

Treatment of disorders mediated by a calcium activated intermediate conductance potassium ion channel antagonist.

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2,2-bis(4-fluorophenyl)-2-phenyl-acetamide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 78)Lieferanten
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InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58

289656-45-7()Verwandte Suche:

2,6-Difluorbenzamid
  • 2,2-bis(4-fluorophenyl)-2-phenyl-acetamide
  • Benzeneacetamide, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-
  • 4-Fluoro-alpha-(4-fluorophenyl)-alpha-phenylbenzeneacetamide
  • 4-Fluoro-A-(4-Fluorophenyl)-A-Phenyl-BenzeneacetaMide
  • ICA 17043
  • Senicapoc
  • ICA-17043;ICA 17043;ICA17043
  • Benzeneacetamide, 4-fluoro-α-(4-fluorophenyl)-α-phenyl-
  • Senicapoc (ICA17043)
  • 289656-45-7
  • C20H15F2NO
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