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Aceton Produkt Beschreibung

CAS-Nr.67-64-1
Bezeichnung:Aceton
Englisch Name:Acetone
Synonyma:
aceton;Acetone;Propanon;(CH3)2CO;Sasetone;ai3-01238;AcetoneGr;2-Propanon;ACETONE,NF;ACETONE,FCC
CBNumber:CB3130928
Summenformel:C3H6O
Molgewicht:58.08
MOL-Datei:67-64-1.mol
Aceton physikalisch-chemischer Eigenschaften
Schmelzpunkt:: -94 °C(lit.)
Siedepunkt:: 56 °C760 mm Hg(lit.)
Dichte: 0.791 g/mL at 25 °C(lit.)
Dampfdichte: 2 (vs air)
Dampfdruck: 184 mm Hg ( 20 °C)
Brechungsindex: n20/D 1.359(lit.)
FEMA : 3326 | ACETONE
Flammpunkt:: 1 °F
storage temp. : Store at RT.
Löslichkeit: Miscible with water and with ethanol (96 per cent).
pka: 19.3(at 25℃)
Aggregatzustand: Liquid
Farbe: Colorless, invisible vapor
Wichte: 0.79 (25/25℃)
Relative polarity: 0.355
Geruch (Odor): Characteristic pungent odor detectable at 33 to 700 ppm (mean = 130 ppm)
PH: 5-6 (395g/l, H2O, 20°C)
Explosionsgrenze: 2.6-12.8%(V)
Wasserlöslichkeit: soluble
Merck : 14,66
JECFA Number: 139
BRN : 63580
Expositionsgrenzwerte: TLV-TWA 1780 mg/m3 (750 ppm), STEL 2375 mg/m3 (ACGIH); 10 h–TWA 590 mg/m3 (250 ppm); IDLH 20,000 ppm (NIOSH).
CAS Datenbank: 67-64-1(CAS DataBase Reference)
NIST chemische Informationen: Acetone(67-64-1)
EPA chemische Informationen: 2-Propanone(67-64-1)
Sicherheit
Kennzeichnung gefährlicher: F,Xi,T
R-Sätze:: 11-36-66-67-39/23/24/25-23/24/25
S-Sätze:: 9-16-26-45-36/37-7
RIDADR : UN 1090 3/PG 2
WGK Germany : 3
RTECS-Nr.: AL3150000
F : 3-10
Selbstentzündungstemperatur: 465 °C
TSCA : Yes
HazardClass : 3
PackingGroup : II
HS Code : 29141100
Giftige Stoffe Daten: 67-64-1(Hazardous Substances Data)
Toxizität: LD50 in rats: 10.7 ml/kg orally (Smyth)

Aceton Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.
PHYSIKALISCHE GEFAHREN
Die Dämpfe sind schwerer als Luft und können sich am Boden ausbreiten. Fernzündung möglich.
CHEMISCHE GEFAHREN
Bildung explosionsfähiger Peroxide bei Kontakt mit starken Oxidationsmitteln wie Essigsäure, Salpetersäure, Wasserstoffperoxid. Reagiert mit Chloroform und Bromoform in Gegenwart von Alkali. Feuer- und Explosionsgefahr. Greift Kunststoffe an.
ARBEITSPLATZGRENZWERTE
TLV: 500 ppm (als TWA); 750 ppm (als STEL); Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); BEI vorhanden; (ACGIH 2005).
MAK: 500 ppm, 1200 mg/m? Spitzenbegrenzung: überschreitungsfaktor I(2); Schwangerschaft: Gruppe D; (DFG 2006).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation und über die Haut.
INHALATIONSGEFAHREN
Beim Verdampfen bei 20 °C kann schnell eine gesundheitsschädliche Kontamination der Luft eintreten, beim Dispergieren jedoch viel schneller.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Der Dampf reizt die Augen und die Atmungsorgane. Möglich sind Auswirkungen auf Zentralnervensystem, Leber, Nieren und Magendarmtrakt.
WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION
Wiederholter oder andauernder Hautkontakt kann Dermatitis hervorrufen. Möglich sind Auswirkungen auf Blut und Knochenmark.
LECKAGE
Persönliche Schutzausrüstung: Umgebungsluftunabhängiges Atemschutzgerät. Belüftung. Ausgelaufene Flüssigkeit in abdichtbaren Behältern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen. NICHT in die Kanalisation spülen. Dann mit viel Wasser wegspülen.
R-Sätze Betriebsanweisung:
R11:Leichtentzündlich.
R36:Reizt die Augen.
R66:Wiederholter Kontakt kann zu spröder oder rissiger Haut führen.
R67:Dämpfe können Schläfrigkeit und Benommenheit verursachen.
R39/23/24/25:Giftig: ernste Gefahr irreversiblen Schadens durch Einatmen, Berührung mit der Haut und durch Verschlucken.
R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S9:Behälter an einem gut gelüfteten Ort aufbewahren.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Aussehen Eigenschaften
C3H6O; 2-Propanon, Propanon, Dimethylketon. Farblose, charakteristisch riechende Flüssigkeit.
Gefahren für Mensch und Umwelt
Reizt die Augen. Wiederholter Kontakt kann zu spöder Haut führen. Aufnahme grösserer Mengen durch Inhalation führt zu Schläfrigkeit und Benommenheit.
Leicht entzündlich.
Nicht mit Alkalihydroxiden, Halogenen, Halogenkohlenwasserstoffen/Alkalihydoxiden, Halogen-Halogenverbindungen, Oxidationsmitteln(z.B. CrO3, Peroxiden, Salpetersäure, Nitriersäure), Halogenoxiden, Alkalimetallen, Nitrosylverbindungen, Metallen und Ethanolamin in Berührung bringen.
Gefährliche Zersetzungsprodukte sind Peroxide.
LD50 (oral, Ratte): 5800 mg/kg
Schutzmaßnahmen und Verhaltensregeln
Geeignete Schutzhandschuhe als kurzzeitiger Spritzschutz.
Verhalten im Gefahrfall
Für Frischluft sorgen. Dämpfe nicht einatmen.
Nicht in die Kanalisation gelangen lassen.
Mit flüssigkeitsbindendem Material aufnehmen. Der Entsorgung zuführen. Nachreinigen.
Wasser, Kohlendioxid.
Brennbar. Mit Luft Bildung explosionsfähiger Gemische möglich. Dämpfe schwerer als Luft.
Erste Hilfe
Nach Hautkontakt: Mit reichlich Wasser abwaschen.
Nach Augenkontakt: Bei geöffnetem Lidspalt mit reichlich fliessendem Wasser (Augendusche!) mindestens 15 Minuten ausspülen. Sofort Augenarzt hinzuziehen.
Nach Einatmen: Frischluft. Arzt hinzuziehen.
Nach Verschlucken: Reichlich Wasser trinken. Erbrechen wegen Aspirationsgefahr vermeiden. Nachgabe von 20 - 40 g Aktivkohle als 10%ige Aufschlämmung in Wasser. Arzt hinzuziehen.
Nach Kleidungskontakt: Kontaminierte Kleidung entfernen.
Ersthelfer: siehe gesonderten Anschlag

Sachgerechte Entsorgung
Als halogenfreie, organische Lösemittelabfälle.
Beschreibung
Acetone is a flammable, colorless liquid with a pleasant odor. It is used widely as an organic solvent and in the chemical industry. It is the simplest ketone, which also goes by the name dimethyl ketone (DMK). Acetone was originally referred to as pyroacetic spirit because it was obtained from the destructive distillation of acetates and acetic acid.
Chemische Eigenschaften
A clear liquid with characteristic aromatic odor; pungent, somewhat sweet taste. It is used as a flavor enhancer, flavoring agent or adjuvant solvent, or vehicle washing or surface removal agent. Its quick miscibility with water, alcohol, ether, chloroform and most volatile oils makes acetone a valuable solvent and extractant
Chemische Eigenschaften
Acetone, CH3COCH3, also known as 2-propanone and dimethylketone, is a colorless, volatile,flammable liquid that boils at 56°C (133 OF). It is misciblewith water and is oftenused as a solventin the manufacture of lacquers and paints.
Chemische Eigenschaften
Acetone is a highly flammable, colorless liquid with a sweet, mint-like odor
Chemische Eigenschaften
Acetone is a colorless volatile, flammable, transparent liquid, with a sweetish odor and pungent sweetish taste.
Occurrence
Reported found in apple, pear, grape, pineapple, strawberry, raspberry, tomato, black currant, citrus, onion and potato; also reported found in cocoa leaves, in Mexican goosefoot and in the oils of coriander and lavender. In trace amounts it has been reportedly identified in the oil of bitter orange, in distilled wine and in coffee aroma
History
The traditional method of producing acetone in the 19th century and the beginning of the 20th century was to distill acetates, particularly calcium acetate, Ca(C2H3O2)2.
Weizmann discovered a process to produce butyl alcohol and acetone from the bacterium Clostridium acetobutylicum in 1914. With England’s urgent demand for acetone, Winston Churchill (1874–1965) enlisted Weizmann to develop the Weizmann process for acetone production on an industrial scale. Fermentation and distillation techniques for acetone production were replaced starting in the 1950s with the cumene oxidation process . In this process, cumene is oxidized to cumene hydroperoxide, which is then decomposed using acid to acetone and phenol. This is the primary method used to produce phenol, and acetone is produced as a co-product in the process, with a yield of about 0.6:1 of acetone to phenol.
Verwenden
Acetone is used in the manufacture of a largenumber of compounds, such as acetic acid,chloroform, mesityl oxide, and MIBK; in themanufacture of rayon, photographic films,and explosives; as a common solvent; inpaint and varnish removers; and for purifyingparaffins.
Verwenden
Acetone is used in the chemical industry in numerous applications. The primary use of acetone is to produce acetone cyanohydrin, which is then used in the production of methyl methacrylate (MMA). Another use of acetone in the chemical industry is for bisphenol A (BPA). BPA results form the condensation reaction of acetone and phenol in the presence of an appropriate catalyst. BPA is used in polycarbonate plastics, polyurethanes, and epoxy resins. Polycarbonate plastics are tough and durable and are often used as a glass substitute.
In addition to its use as a chemical feedstock and intermediate, acetone is used extensively as an organic solvent in lacquers, varnishes, pharmaceuticals, and cosmetics. Nail polish remover is one of the most common products containing acetone. Acetone is used to stabilize acetylene for transport .
Verwenden
Acetone′s luminesence intensity is dependent upon the solution components 1. The absorption of UV light by acetone, results in its photolysis and the production of radials 1.
Verwenden
Suitable for HPLC, spectrophotometry, environmental testing
Verwenden
Used in liquid chromotography; cleaning glassware; extraction of solid waste.
Verwenden
Solvent for fats, oils, waxes, resins, rubber, plastics, lacquers, varnishes, rubber cements. manufacture of methyl isobutyl ketone, mesityl oxide, acetic acid (ketene process), diacetone alcohol, chloroform, iodoform, bromoform, explosives, aeroplane dopes, rayon, photographic films, isoprene; storing acetylene gas (takes up about 24 times its vol of the gas); extraction of various principles from animal and plant substances; in paint and varnish removers; purifying paraffin; hardening and dehydrating tissues. Pharmaceutic aid (solvent).
Verwenden
acetone is a solvent considered to be non-comedogenic and occasionally used in skin toners. It is primarily used in nail polish remover. It could be drying and very irritating to the skin depending on the concentration and frequency of use.
Definition
ChEBI: A methyl ketone that consists of propane bearing an oxo group at C2.
Vorbereitung Methode
Acetone can also be produced from isopropanol using several methods, but the main methodis by catalytic dehydrogenation.
Vorbereitung Methode
Acetone is obtained by fermentation as a by-product of n-butyl alcohol manufacture, or by chemical synthesis from isopropyl alcohol; from cumene as a by-product in phenol manufacture; or from propane as a by-product of oxidation-cracking.
Aroma threshold values
Detection: 40 to 476 ppm
Allgemeine Beschreibung
A clear colorless liquid with a sweetish odor. Flash point 0°F. Less dense than water. Vapors are heavier than air. Used as a solvent in paint and nail polish removers.
Air & Water Reaktionen
Highly flammable. Water soluble.
Reaktivität anzeigen
Acetone was reported that a mixture of Acetone and chloroform, in a residue bottle, exploded. Since addition of Acetone to chloroform in the presence of base will result in a highly exothermic reaction, Acetone is thought that a base was in the bottle [MCA Case History 1661. 1970]. Also, Nitrosyl chloride, sealed in a tube with a residue of Acetone in the presence of platinum catalyst, gave an explosive reaction [Chem. Eng. News 35(43):60. 1967]. The reaction of nitrosyl perchlorate and Acetone ignites and explodes. Explosions occur with mixtures of nitrosyl perchlorate and primary amine [Ann. Chem. 42:2031. 1909]. Reacts violently with nitric acid. Also causes exothermic reaction when in contact with aldehydes.
Health Hazard
INHALATION: vapor irritating to eyes and mucous membranes; acts as an anesthetic in very high concentrations. INGESTION: low order of toxicity but very irritating to mucous membranes. SKIN: prolonged excessive contact causes defatting of the skin, possibly leading to dermatitis.
Health Hazard
The acute toxicity of acetone is low. Acetone is primarily a central nervous system depressant at high concentrations (greater than 12,000 ppm). Unacclimated volunteers exposed to 500 ppm acetone experienced eye and nasal irritation, but it has been reported that 1000 ppm for an 8-hour day produced no effects other than slight transient irritation to eyes, nose, and throat. Therefore there are good warning properties for those unaccustomed to working with acetone; however, frequent use of acetone seems to cause accommodation to its slight irritating properties. Acetone is practically nontoxic by ingestion. A case of a man swallowing 200 mL of acetone resulted in his becoming stuporous after 1 hour and then comatose; he regained consciousness 12 hour later. Acetone is slightly irritating to the skin, and prolonged contact may cause dermatitis. Liquid acetone produces moderate transient eye irritation. Acetone has not been found to be carcinogenic in animal tests or to have effects on reproduction or fertility.
Health Hazard
The acute toxicity of acetone in testanimals was found to be low. However,in large dosages it could be moderatelytoxic. Inhalation can cause irritation ofthe eyes, nose, and throat. A shortexposure for 5 minutes to 300–500 ppmcan be slightly irritating to humans. Theodor threshold is 200–400 ppm. In highconcentrations it can produce dryness in themouth, fatigue, headache, nausea, dizziness,muscle weakness, loss of coordinatedspeech, and drowsiness. Ingestion cancause headache, dizziness, and dermatitis.Swallowing 200–250 mL can result invomiting, stupor, and coma in humans. Adose of 25 mg/kg may be fatal to dogs.
LD50 value, oral (rats): 5800 mg/k No mutagenic or carcinogenic effects havebeen reported.
Brandgefahr
Acetone is extremely flammable (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." Acetone vapor forms explosive mixtures with air at concentrations of 2 to 13% (by volume). Carbon dioxide or dry chemical extinguishers should be used for acetone fires.
Brandgefahr
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Flammability and Explosibility
Acetone is extremely flammable (NFPA rating = 3), and its vapor can travel a considerable distance to an ignition source and "flash back." Acetone vapor forms explosive mixtures with air at concentrations of 2 to 13% (by volume). Carbon dioxide or dry chemical extinguishers should be used for acetone fires.
Pharmazeutische Anwendungen
Acetone is used as a solvent or cosolvent in topical preparations, and as an aid in wet granulation.It has also been used when formulating tablets with water-sensitive active ingredients, or to solvate poorly water-soluble binders in a wet granulation process. Acetone has also been used in the formulation of microspheres to enhance drug release.Owing to its low boiling point, acetone has been used to extract thermolabile substances from crude drugs.
Industrielle Verwendung
Acetone is valuable solvent component in acrylic/nitrocellulose automotive lacquers. Acetone is the solvent of choice in film coatings operations which use vinylidene chloride-acrylonitrile copolymer formulations.Other ketones that may be used in these film coating operations include methyl isobutyl ketone, ethyl n-amyl ketone, and diisobutyl ketone.Acetone, blends of MIBK and MEK, methyl namyl ketone, ethyl n-amyl ketone, and diisobutyl ketone are all useful solvents for vinyl resin copolymers. The presence of one of the slower evaporating ketones in the solvent blend prevents quick drying, improves flow, and gives blush resistance to the coating. Acetone is also used as a resin thinner in polyester resins and as a clean up solvent for the resin reactor kettle.In solvents industry, Acetone is a component of solvent blends in urethane, nitrile rubber, and neoprene industrial adhesives.Acetone is the primary solvent in resin-type adhesives and pressure sensitive chlorinated rubber adhesives. Acetone also can be used to extract fats, oils, waxes, and resins from natural products, to dewax lubricating oils, and to extract certain essential oils.Acetone is also an important chemical intermediate in the preparation of several oxygenated solvents including the ketones, diacetone alcohol, mesityl oxide, methyl isobutyl ketone, and isophorone.
Sicherheitsprofil
Moderately toxic by various routes. A skin and severe eye irritant. Human systemic effects by inhalation: changes in EEG, changes in carbohydrate metabolism, nasal effects, conjunctiva irritation, respiratory system effects, nausea and vomiting, and muscle weakness. Human systemic effects by ingestion: coma, kidney damage, and metabolic changes. Narcotic in high concentration. In industry, no injurious effects have been reported other than skin irritation resulting from its defatting action, or headache from prolonged inhalation. Experimental reproductive effects. A common air contaminant. Highly flammable liquid. Dangerous disaster hazard due to fire and explosion hazard; can react vigorously with oxidizing materials. Potentially explosive reaction with nitric acid + sulfuric acid, bromine trifluoride, nitrosyl chloride + platinum, nitrosyl perchlorate, chromyl chloride, thiotrithiazyl perchlorate, and (2,4,6-trichloro-l,3,5triazine + water). Reacts to form explosive peroxide products with 2-methyl-1,3butadiene, hydrogen peroxide, and peroxomonosulfuric acid. Ignites on contact with activated carbon, chromium trioxide, dioxygen difluoride + carbon dioxide, and potassium-tert-butoxide. Reacts violently with bromoform, chloroform + alkalies, bromine, and sulfur dichloride. Incompatible with CrO, (nitric + acetic acid), NOCl, nitryl perchlorate, permonosulfuric acid, NaOBr, (sulfuric acid + potassium dichromate), (tho-diglycol + hydrogen peroxide), trichloromelamine, air, HNO3, chloroform, and H2SO4. To fight fire, use Con, dry chemical, alcohol foam. Used in production of drugs of abuse
Sicherheit(Safety)
Acetone is considered moderately toxic, and is a skin irritant and severe eye irritant. Skin irritation has been reported due to its defatting action, and prolonged inhalation may result in headaches. Inhalation of acetone can produce systemic effects such as conjunctival irritation, respiratory system effects, nausea, and vomiting.
LD50 (mouse, oral): 3.0 g/kg
LD50 (mouse, IP): 1.297 g/kg
LD50 (rabbit, oral): 5.340 g/kg
LD50 (rabbit, skin): 0.2 g/kg
LD50 (rat, IV): 5.5 g/kg
LD50 (rat, oral): 5.8 g/kg
Chemical Synthesis
By fermentation, or by chemical synthesis from isopropanol, cumene or propane
mögliche Exposition
It is used as a solvent in nail polish remover and many other chemicals. Used in the production of lubricating oils and as an intermediate in the manufacture of chloroform and of various pharmaceuticals and pesticides.
Enzyminhibitor
This common organic solvent (FW = 58.08 g/mol; CAS 67-64-1; M.P. = – 94.7 °C; B.P. = 56.3 °C; flammable liquid; freely soluble in water, ethanol, chloroform, and other polar organic solvents; dipole moment of 2.69 D at 20°C; dielectric constant of 20.7 at 25°C), inhibits many enzymes by forming reversible adducts with active-site amino and thiol groups. Acetone is also a nonspecific protein denaturant at high concentrations. A highly effective lipid-extracting solvent, ice-cold acetone is frequently used to prepare tissue powders that are both long-lived and well suited for the extraction and purification of both water-soluble and membrane-associated proteins. Target (s) : catechol 2,3-dioxygenase; subtilisin ; lipase, or triacylglycerol lipase; acetyl-CoA carboxylase ; L-glycol dehydrogenase; sterol O acyltransferase, or cholesterol O-acyltransferase, or ACAT; microsomal glycerol-3-phosphate O-acyltransferase; b-fructofuranosidase, or invertase; a- glucosidase, or maltase; b-lactamase; carbonic anhydrase, weakly inhibited; DNA polymerase; camphor 5-monooxygenase, or CYP101; chymotrypsin; Ca2+-dependent ATPase; epoxide hydrolase; acetoacetate decarboxylase; enolase, in presence of ammonium sulfate and EDTA; diacetyl reductase, or a-diketone reductase, NAD+-dependent; adenylate cyclase, or adenyl cyclase ; esterase or lipase; asparaginase; cystathionine g-lyase, or cysteine desulfurase; dihydropyrimidinase, or hydantoinase; pyrophosphatase, or inorganic diphosphatase; aminoacylase; ribonuclease A, in the presence of sodium borohydride; 3- hydroxybutyrate dehydrogenase; hydroxynitrilase, or hydroxynitrile lyase; uroporphyrinogen decarboxylase; myosin ATPase, strongly inhibited under alkaline conditions; thiamin-triphosphatase ; cytidine deaminase; pantothenase; arylformamidase; coagulation factor IXa; pyroglutamyl-peptidase I; cholesterol-5,6- oxide hydrolase ; soluble epoxide hydrolase (47-49); poly (ADP- ribose) glycohydrolase; b-D-fucosidase; chitinase; retinyl- palmitate esterase; carboxylesterase, weakly inhibited; diacylglycerol cholinephosphotransferase; ethanolaminephospho- transferase; N acetyllactosamine synthase; lactose synthase; glucuronosyltransferase; 2,3 diaminopropionate N-oxalyltransferase ; 2-acylglycerol O-acyltransferase, or monoacylglycerol O- acyltransferase, weakly inhibited; steroid 11b-monooxygenase; bacterial luciferase, or alkanal monooxygenase (FMN-linked), weakly inhibited; phenylacetone monooxygenase; nitronate monooxygenase; biphenyl-2,3-diol 1,2-dioxygenase; peroxidase ; and laccase.
Erste Hilfe
If this chemical gets into the eyes, remove any contact lenses at once, and irrigate immediately with large amounts of water for at least 15 minutes. If this chemical contacts the skin, quickly remove contaminated clothing, and wash with large amounts of soap immediately. If a person breathes in large amounts of this chemical, move the exposed person to fresh air at once, and perform (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
Lager
Acetone should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers.
Lager
Acetone should be stored in a cool, dry, well-ventilated place out of direct sunlight.
Versand/Shipping
UN1090 Acetone, Hazard Class: 3; Labels: 3-Flammable liquid
läuterung methode
The commercial preparation of acetone by catalytic dehydrogenation of isopropyl alcohol gives relatively pure material. Analytical reagent quality generally contains less than 1% of organic impurities but may have up to about 1% of H2O. Dry acetone is appreciably hygroscopic. The main organic impurity in acetone is mesityl oxide, formed by aldol condensation. It can be dried with anhydrous CaSO4, K2CO3 or type 4A Linde molecular sieves, and then distilled. Silica gel and alumina, or mildly acidic or basic desiccants cause acetone to undergo the aldol condensation, so that its water content is increased by passage through these reagents. This also occurs to some extent when P2O5 or sodium amalgam is used. Anhydrous MgSO4 is an inefficient drying agent, and CaCl2 forms an addition compound. Drierite (anhydrous CaSO4) offers minimum acid and base catalysis for aldol formation and is the recommended drying agent for this solvent [Coetzee & Siao Inorg Chem 14 2 1987, Riddick & Bunger Organic Solvents Wiley-Interscience, N.Y., 3rd edn, 1970]. Acetone can be shaken with Drierite (25g/L) for several hours before it is decanted and distilled from fresh Drierite (10g/L) through an efficient column, maintaining atmospheric contact through a Drierite drying tube. The equilibrium water content is about 10-2M. Anhydrous Mg(ClO4)2 should not be used as drying agent because of the risk of EXPLOSION with acetone vapour. Organic impurities have been removed from acetone by adding 4g of AgNO3 in 30mL of water to 1L of acetone, followed by 10mL of M NaOH, shaking for 10minutes, filtering, drying with anhydrous CaSO4 and distilling [Werner Analyst (London) 58 335 1933]. Alternatively, successive small portions of KMnO4 have been added to acetone at reflux, until the violet colour persists, followed by drying and distilling. Refluxing with chromium trioxide (CrO3) has also been used. Methanol has been removed from acetone by azeotropic distillation (at 35o) with methyl bromide, and treatment with acetyl chloride. Small amounts of acetone can be purified as the NaI addition compound, by dissolving 100g of finely powdered NaI in 400g of boiling acetone, then cooling in ice and salt to -8o. Crystals of NaI.3Me2CO are filtered off and, on warming in a flask, acetone distils off readily. [This method is more convenient than the one using the bisulfite addition compound.] It has also been purified by gas chromatography on a 20% free fatty acid phthalate (on Chromosorb P) column at 100o. For efficiency of desiccants in drying acetone see Burfield and Smithers [J Org Chem 43 3966 1978]. The water content of acetone can be determined by a modified Karl Fischer titration [Koupparis & Malmstadt Anal Chem 54 1914 1982]. [Beilstein 1 IV 3180.] Rapid procedure: Dry over anhydrous CaSO4 and distil.
Inkompatibilitäten
May explode when mixed with chloroform, chromic anhydride. Incompatible with acids, bases, and oxidizing materials, such as peroxides, chlorates, perchlorates, nitrates, and permanganates. Unstable peroxides formed with strong oxidizers. May accumulate static electrical charges and may cause ignition of its vapors. Dissolves most rubber, resins, and plastics.
Inkompatibilitäten
Acetone reacts violently with oxidizing agents, chlorinated solvents, and alkali mixtures. It reacts vigorously with sulfur dichloride, potassium t-butoxide, and hexachloromelamine. Acetone should not be used as a solvent for iodine, as it forms a volatile compound that is extremely irritating to the eyes.
Waste disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration.
Regulatory Status
Included in the FDA Inactive Ingredients Database (inhalation solution; oral tablets; topical preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients. Included in nonparenteral medicines licensed in the UK.
Aceton Upstream-Materialien And Downstream Produkte
Upstream-Materialien
(1-Methylethyl)benzol 2-Amino-3-chlorbenzoesure 2-Methylpropanol-2 Loesungsmittelnaphtha (Erdoel), leichte aliphatische Zinkchromat Benzol Cumolhydroperoxid Diisopropylbenzol Calciumdi(acetat) p-Cymol Holzessige
Downstream Produkte
Chalkon Orciprenalin p-(Benzyloxy)phenethylalkohol 9,10-Dihydro-9,9-dimethylacridin 7-Methoxycumarin Pentaerithrityltetranitrat 7-Ethoxycumarin 2-Iodacetamid Benzophenon-3,3':4,4'-tetracarbonsaeuredianhydrid Ethoxychin 4-(4-Hydroxyphenyl)but-3-en-2-on Dimethyl-(2-oxopropyl)phosphonat Triiodmethan Amikacinbis(sulfat) 3,5,5-Trimethyl-2-cyclohex-2-enon 5-Methoxy-2-methylindol Epinephrin 2-Bromdodecansure Cinchophen 2-Methyl-3-butin-2-ol 3-(Dimethylamino)propiophenonhydrochlorid 1,1,3,3-Tetramethyl-1,3-divinyldisiloxan 3-Methyl-2-thenoesure
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67-64-1(Aceton)Verwandte Suche:
Pentan-2-on 1,2:5,6-di-O-isopropyliden-α-D-glucofuranose 2-Brom-1-(4-fluorphenyl)ethan-1-on Paroxypropion 4-Methoxyphenylaceton Tris(pentan-2,4-dionato-O,O')lanthan Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')dysprosium Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')praseodym Phenylselenol Tris(2,2,6,6-tetramethylheptan-3,5-dionato-O,O')europium 2-Methylpropylisocyanid Aceton Propiophenon Citric acid monohydrate 2,4-Pentandion 4-Hydroxy-4-methylpentan-2-on Brenztraubensure
ACETONE ALCOHOL GRAMS DECOLORIZER GRAM STAIN NO 3 (CH3)2CO 2-Propanon ketone,dimethyl ketonepropane -Ketopropane propan-2-one Propanon propanone(acetone) pyroaceticacid Rcra waste number U002 rcrawastenumberu002 ACETONE E PESTANAL ACETONE 99+% FCC ACETONE DIST. 1 L ACETONE SEMICONDUCTOR GRADE MOS PURANAL ACETONE 'B&J BRAND' 4 L ACETONE SPECTRANAL, REAG. ACS ACETONE, REAGENTPLUS, PHENOL FREE, >=99.5% ACETONE, ACS, FOR UV-SPECTROSCOPY ACETONE, >=99.5%, A.C.S. REAGENT ACETONE >=99.9% HPLC GRADE (PURE-PAC ACETONE >=99.5% A.C.S. SPECTROPHOTOME& ACETONE 97+% NATURAL ACETONE, 4X25 ML ACETONE, CHROMASOLV PLUS, FOR HPLC, 99.& ACETONE SEMICONDUCTOR GRADE ULSI PURANAL ACETONE, DIST. FOR HPLC, 6X1 L ACETONE, >=99.5%, A.C.S. REAGENT (POLY-COATED BOTTLES) ACETONE CLEANING SOLUTION ACETONE >=99.5% A.C.S. REAGENT (POLY-& ACETONE EXTRA PURE, DAB, PH. FRANC.,N. F ACETONE, PH EUR ACETONE, >=99.5%, A.C.S. REAGENT (SAFETY CAN) ACETONE, 99.5+%, HISTOLOGICAL GRADE ACETONE, >=99.5%, A.C.S. SPECTROPHOTOMETRIC GRADE ACETONE 99.9% B&J BRAND ACETONE, FOR RESIDUE ANALYSIS ACETONE EP, BP, NF ACETONE, STANDARD FOR GC ACETONE, DIST. FOR HPLC, 4X2.5 L ACETONE D FOR ANALYSIS OF DIOXINES, FURA ACETONE >=99.5% A.C.S. REAGENT (SAFET& ACETONE PESTANAL ACETONE R. G., PE BOTTLE, REAG. ACS, REAG. ISO, REAG. PH. EUR. ACETONE, 1X1ML, MEOH:WATER(90:10), 5000U G/ML ACETONE, A.C.S. REAGENT, >=99.5% ACETONE FOR HPLC ACETONE CHROMASOLV FOR HPLC >=99.9% ACETONE, REAGENTPLUS, >=99% ACETONE TECHNICAL, 5 L ACETONE CHROMASOLV FOR HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY ACETONE DIST. 5 L ACETONE,ELECTRONIC/CLEANROOMGRADE ACETONE,FCC ACETONE,GCSOLV
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