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Dexpanthenol Produkt Beschreibung

Dexpanthenol Struktur
81-13-0
CAS-Nr.
81-13-0
Bezeichnung:
Dexpanthenol
Englisch Name:
Dexpanthenol
Synonyma:
Cozyme;Ilopan;Pantol;Urupan;Proleus;Motilyn;Panadon;synapan;Bepantol;Intrapan
CBNumber:
CB3169304
Summenformel:
C9H19NO4
Molgewicht:
205.25
MOL-Datei:
81-13-0.mol

Dexpanthenol Eigenschaften

Schmelzpunkt:
64~69℃
alpha 
30.5 º (c=5, H2O on anh. sub)
Siedepunkt:
118-120 °C (2.7 mmHg)
Dichte
1.20 g/mL at 20 °C (lit.)
Brechungsindex
1.495-1.502
Flammpunkt:
118-120°C/0.02m
storage temp. 
2-8°C
Aggregatzustand
Viscous Liquid or Semi Solid
pka
13.03±0.20(Predicted)
Farbe
Clear colorless to slightly yellow
PH
pH (100g/l,25℃) : 8.5~10.5
Optische Aktivität
[α]20/D +30±1°, c = 5% in H2O
Wasserlöslichkeit
soluble
Sensitive 
Hygroscopic
Merck 
14,2947
BRN 
1724947
InChIKey
SNPLKNRPJHDVJA-ZETCQYMHSA-N
CAS Datenbank
81-13-0(CAS DataBase Reference)
NIST chemische Informationen
Dexpanthenol(81-13-0)
EPA chemische Informationen
(+)-Panthenol (81-13-0)

Sicherheit

Kennzeichnung gefährlicher Xn
R-Sätze: 36/37/38-48-41-37/38-20/21/22
S-Sätze: 23-24/25-45-36/37/39-26-22
WGK Germany  1
RTECS-Nr. ES4316000
3-10
TSCA  Yes
HS Code  29241990
Giftige Stoffe Daten 81-13-0(Hazardous Substances Data)
Toxizität LD50 oral in mouse: 15gm/kg

Dexpanthenol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R48:Gefahr ernster Gesundheitsschäden bei längerer Exposition.
R41:Gefahr ernster Augenschäden.
R37/38:Reizt die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S22:Staub nicht einatmen.

Chemische Eigenschaften

clear colorless to slightly yellow viscous liquid

Originator

Bepanthene,Roche,France,1951

Verwenden

Dexpanthenol may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques as well as partial least-squares multivariate calibration.

Verwenden

cholinergic

Verwenden

D-Panthenol is an analogue of pantothenic acid (P190300), a member of the B complex vitamins. D-Panthenol is the biologically active enantiomer of Panthenol.

Verwenden

immunosuppressant, mitoxantrone analogue less toxic on cardiac tissue antineoplastic

Manufacturing Process

130 parts by weight of d(-)-α-hydroxy-β,β-dimethyl-gamma-butyric acid lactone are dissolved in 150 parts by volume of methyl alcohol. 75 parts by weight of 3-hydroxypropylamine are added, in one portion, to the solution and the mixture is well stirred. While the reaction sets in, the temperature of the mixture gradually rises by itself to about 50°C and then drops again after about two hours. To cause completion of the reaction, the mixture is allowed to stand at room temperature for 24 hours. The so obtained (d+)-α,γdihydroxy-β,β-dimethyl-butyric-acid-(3'-hydroxypropyl)-amide is freed from methyl alcohol in vacuo. It is a colorless, viscous oil, easily soluble in water. It boils under a pressure of 0.02 mm between 118° and 120°C.

Trademarks

D-Panthenol 50 (BASF); Ilopan (Savage); Motilyn (Abbott).

Therapeutic Function

Gastrointestinal drug

Allgemeine Beschreibung

Dexpanthenol is an alcohol analog of pantothenic acid and an important component of parenterals, local cosmetic preparations and multi-vitamins. It has as much biological activity as pantothenic acid and is found to be stable in aqueous solution.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biochem/physiol Actions

D-Panthenol is the alcohol analogue and biological precursor of D-pantothenic acid. These analogues are precursors in the biosynthesis of coenzyme A. D-Panthenol and D-Pantothenic acid are used in a variety of skin protection products. D-pantothenic acid may have a role in controlling keratinocyte proliferation and differentiation. D-Panthenol may be used for studies of skin protection emulsions from UV irradiation and as a humectant.

Kontakt-Allergie

Pan(to)thenol is the alcohol corresponding to pantothenic acid, of the vitamin B5 group. It is used as a food additive, and in skin and hair products as a conditioning agent. Contact dermatitis and urticaria have been reported.

Sicherheitsprofil

Moderately toxic by intravenous route. A skin and eye irritant. When heated to decomposition it emits toxic fumes of NOx. See also AMIDES.

Veterinary Drugs and Treatments

Dexpanthenol has been suggested for use in intestinal atony or distension, postoperative retention of flatus and feces, prophylaxis and treatment of paralytic ileus after abdominal surgery or traumatic injuries, equine colic (not due to mechanical obstruction) and any other condition when there is an impairment of smooth muscle function. Controlled studies are lacking with regard to proving the efficacy of the drug for any of these indications.

läuterung methode

Purify D-panthenol by distillation in vacuo. It is a slightly hygroscopic viscous oil and is soluble in H2O and organic solvents. It is hydrolysed by alkali and strong acid. [Rabin J Am Pharm Assoc (Sci Ed) 37 502 1948, Bonati & Pitré Farmaco Ed Scient 14 43 1959, Beilstein 4 IV 1652.]

Dexpanthenol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dexpanthenol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 422)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Hebei Yime New Material Technology Co., Ltd.
+8617703311139
admin@china-yime.com China 278 58
Hengshui Haoye Chemical Co.,Ltd.
0318-2102300
hy@chemcoms.com CHINA 224 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
ZhenYiBio Technology Inc
+8615309206328
86-029-89189705 alexxue@zhenyibio.com China 299 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15418 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com China 9165 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Tianjin Zhongxin Chemtech Co., Ltd.
+8618622897568 +86-022-66880623
022-66880086 sales@tjzxchem.com China 543 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58

81-13-0(Dexpanthenol)Verwandte Suche:


  • 4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-(theta)-butanamid
  • 4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-d-(+)-butyramid
  • Alcopan-250
  • Bepanthen
  • Bepanthene
  • Bepantol
  • Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-
  • Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (R)-
  • Butanamide,2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-,(R)-
  • Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, D-(+)-
  • compnent of ilopan-Choline
  • component of Ilopan-choline
  • component of Pantho-F
  • component of Zentinic
  • Cozyme
  • D-2,4-Dihydroxy-3,3-dimethyl-N-(3-hydroxypropyl)butyramide
  • Dextro pantothenyl alcohol
  • D-P-A Injection
  • Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)-
  • DEXPANTHENOL,FCC
  • PANTHENOL, D-(DEXPANTHENOL)(PROVITAMIN B)(RG)
  • Butanamide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, (2R)- (9CI)
  • Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, D-(+)- (8CI)
  • D(+)-a,g-Dihydroxy-N-(3-hydroxypropyl)-b,b-dimethylbutyramide
  • NSC 302962
  • Provitamin B5
  • 4-dihydroxy-n-(3-hydroxypropyl)-3,3-dimethyl-d-(+)-butyramide
  • (+)-Panthenol
  • D-Panthenol, D-Pantothenyl alcohol, Dexpanthenol, Dexpanthenolum, Provitamin B, (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, (R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
  • D-Pantothenyl alcohol, Dexpanthenol, Provitamin B, (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, (R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
  • (2R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
  • Proleus
  • Dexpanthenol,(R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, D-Panthenol, D-Pantothenyl alcohol, Dexpanthenol, Dexpantheno
  • D-Panthenol,(R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide, (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide, D-Pantothenyl alcohol, Dexpanthenol, Provitamin B
  • Dexpanthenol (500 mg)
  • d Panthenol 70%
  • D-Panthenol 50L
  • D-Panthenol 75L
  • D-Panthenol, Dexpanthenol
  • D-Panthenol, 98+% 100GR
  • D-Panthenol, 98+% 500GR
  • (R)-3-(2,4-Dihydroxy-3,3-dimethylbutyramido)-1-propanol (R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide D-Pantothenyl Alcohol
  • PANTHENOL, D-(P)
  • D-Panthenol 0
  • D-N-PANTOYL-3-PROPANOLAMINE
  • D(+)-PANTHENOL
  • D-PANTHENOL
  • D-PANTOTHENOL
  • D(+)-PANTOTHENYL ALCOHOL
  • D-PANTOTHENYL ALCOHOL
  • D-PANTOTHENYLOL
  • PANTHENOL, D-
  • (R)-2,4-DIHYDROXY-3,3-DIMETHYLBUTYRIC 3-HYDROXYPROPYLAMIDE
  • (R)-2,4-DIHYDROXY-N-(3-HYDROXYPROPYL)-3,3-DIMETHYLBUTANAMIDE
  • (R)-(+)-2,4-DIHYDROXY-N-(3-HYDROXYPROPYL)-3,3-DIMETHYLBUTYRAMIDE
  • (R)-2,4-DIHYDROXY-N-(3-HYDROXYPROPYL)-3,3-DIMETHYLBUTYRAMIDE
  • (R)-3-(2,4-DIHYDROXY-3,3-DIMETHYLBUTYRAMIDO)-1-PROPANOL
  • PROVITAMIN B
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