L-744,832

L-744,832 Struktur
1177806-11-9
CAS-Nr.
1177806-11-9
Englisch Name:
L-744,832
Synonyma:
L-744832;L-744,832;L-744,832 Dihydrochloride;L-744,832 - CAS 1177806-11-9 - Calbiochem;(2S)-[(2S)-[(2R)-AMINO-3-MERCAPTO]-PROPYLAMINO-(3S)-METHYL]PENTYLOXY-3-PHENYLPROPIONYL-METHIONINE SULFONE ISOPROPYL ESTER BIS HYDRCHLORIDE;(2S)-[(2S)-[(2R)-Amino-3-mercapto]-propylamino-(3S)-methyl]pentyloxy-3-phenylpropionyl-methionine Sulfone Isopropyl Ester Bis Hydrchloride,
CBNumber:
CB3188792
Summenformel:
C26H47Cl2N3O6S2
Molgewicht:
632.7
MOL-Datei:
Mol file

L-744,832 Eigenschaften

Schmelzpunkt:
165-168°C
storage temp. 
-20°C Freezer
Löslichkeit
DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
White solid
Farbe
White

Sicherheit

L-744,832 Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

L-744,832 is White Cyrstalline Solid

Verwenden

L-744,832 is ras farnesyltransferase inhibitor. Induces tumor regression in transgenic mice with multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis. Induces p21 expressoin and arrests cells at G1. Causes enhanced mitotic

Allgemeine Beschreibung

A cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties. Rapidly blocks p70S6K activation and DNA synthesis and promotes apoptosis in transgenic mice. Induces p21 expression and cell cycle arrest in the G1 phase. Displays synergistic effect with paclitaxel and epothilones in inhibiting tumor growth. Also mimics many of the effects of Rapamycin (Cat. No. 553210) and may be effective against tumors that exhibit inappropriate activation of the mTOR/p70S6K pathway.

L-744,832 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


L-744,832 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 33)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Alpha Biopharmaceuticals Co., Ltd
+86-411-39042497 +8613921981412
sales@alphabiopharm.com China 886 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439
sales@nextpeptide.com China 19915 58
Aladdin Scientific
+1-833-552-7181
sales@aladdinsci.com United States 52927 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
3bsc@sina.com China 15848 69
Alabiochem Tech.Co., Ltd. 0512-58900862 400-0707518
sales@alabiochem.com China 995 59
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32344 50
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9709 58
Alabiotech Inc. 001-619-354-5251
sales@alabiotech-e.com United States 972 60

1177806-11-9()Verwandte Suche:


  • (2S)-[(2S)-[(2R)-AMINO-3-MERCAPTO]-PROPYLAMINO-(3S)-METHYL]PENTYLOXY-3-PHENYLPROPIONYL-METHIONINE SULFONE ISOPROPYL ESTER BIS HYDRCHLORIDE
  • L-744832
  • (2S)-[(2S)-[(2R)-Amino-3-mercapto]-propylamino-(3S)-methyl]pentyloxy-3-phenylpropionyl-methionine Sulfone Isopropyl Ester Bis Hydrchloride,
  • L-744,832 Dihydrochloride
  • L-744,832
  • L-744,832 - CAS 1177806-11-9 - Calbiochem
  • 1177806-11-9
  • Inhibitors
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