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Galliumtrinitrat Produkt Beschreibung

GALLIUM NITRATE Struktur
13494-90-1
CAS-Nr.
13494-90-1
Bezeichnung:
Galliumtrinitrat
Englisch Name:
GALLIUM NITRATE
Synonyma:
ganite;nsc-15200;Ga(NO3)3nH2O;Wln: ga N-o3*3;GALLIUM NITRATE;galliumtrinitrate;Gallium(Ⅲ) nitrate;GALLIUM (III) NITRATE;Nitricacid,galliumsalt;GALLIUM NITRATE, 99.9%
CBNumber:
CB3209552
Summenformel:
GaN3O9
Molgewicht:
255.74
MOL-Datei:
13494-90-1.mol

Galliumtrinitrat Eigenschaften

Schmelzpunkt:
110°C (dec.)
Aggregatzustand
Liquid
Wasserlöslichkeit
It is soluble in water.
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
R-Sätze: 8-36/37/38
S-Sätze: 17-26-36/37/39
RIDADR  1477
TSCA  Yes
HazardClass  5.1
PackingGroup  III
Bildanzeige (GHS)
Alarmwort
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H272 Kann Brand verstärken; Oxidationsmittel. Oxidierende Flüssigkeiten (Kapitel 2.13), Kategorie 2 (Ox. Liq. 2), H272 Oxidierende Flüssigkeiten (Kapitel 2.13), Kategorie 2 Achtung
Warnung
P210, P220, P221P280, P370+P378,P501
H314 Verursacht schwere Verätzungen der Haut und schwere Augenschäden. Ätzwirkung auf die Haut Kategorie 1B Achtung P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 Verursacht schwere Augenschäden. Schwere Augenschädigung Kategorie 1 Achtung P280, P305+P351+P338, P310
Sicherheit
P221 Mischen mit brennbaren Stoffen unbedingt verhindern.
P303+P361+P353 BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

Galliumtrinitrat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R8:Feuergefahr bei Berührung mit brennbaren Stoffen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S17:Von brennbaren Stoffen fernhalten.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Beschreibung

Gallium nitrate, initially developed as an anticancer agent, was introduced by Fujisawa as an orphan drug for the treatment of cancer-related hypercalcemia and bone metastases that do not respond to adequate hydration. The compound acts specifically on bone by inhibiting calcium resorption and also possibly by stimulating bone formation. Compared with calcitonin and etidronate, gallium nitrate is more potent and substantially longer acting. Other potential uses could be in the treatment of osteoporosis and Paget’s disease.

Chemische Eigenschaften

white; crystal(s) powder(s) [MER06]

Originator

Memorial Sloan-Kettering Cancer Center (U.S.A.)

Verwenden

Regulator (calcium).

Trademarks

Ganite (Genta).

Allgemeine Beschreibung

White crystals.

Air & Water Reaktionen

Deliquescent. Water soluble.

Reaktivität anzeigen

Oxidizing agents, such as GALLIUM NITRATE, can react with reducing agents to generate heat and products that may be gaseous (causing pressurization of closed containers). The products may themselves be capable of further reactions (such as combustion in the air). The chemical reduction of materials in this group can be rapid or even explosive, but often requires initiation (heat, spark, catalyst, addition of a solvent). Explosive mixtures of inorganic oxidizing agents with reducing agents often persist unchanged for long periods if initiation is prevented. Such systems are typically mixtures of solids, but may involve any combination of physical states. Some inorganic oxidizing agents are salts of metals that are soluble in water; dissolution dilutes but does not nullify the oxidizing power of such materials. Organic compounds, in general, have some reducing power and can in principle react with compounds in this class. Actual reactivity varies greatly with the identity of the organic compound. Inorganic oxidizing agents can react violently with active metals, cyanides, esters, and thiocyanates.

Brandgefahr

Flash point data for GALLIUM NITRATE are not available, but GALLIUM NITRATE is probably combustible.

Pharmazeutische Anwendungen

In clinical trials, gallium nitrate has proved to be highly active as an antitumour agent especially against non-Hodgkin’s lymphoma and bladder cancer. The cytotoxic activity of gallium nitrate has been demonstrated as single agent and as part of combination therapy, for example, together with fluorouracil. Gallium nitrate shows a relatively low toxicity and does not produce myelosuppression, which is a significant advantage over other traditional anticancer agents. Furthermore, it does not appear to show any cross-resistance with conventional chemotherapeutic agents.
These studies have also shown that gallium nitrate is able to decrease serum calcium levels in patients with tumour-induced hypercalcaemia. Subsequently, several studies have been carried out comparing traditional bisphosphonate drugs with gallium nitrate in their ability to decrease the calcium levels that are elevated as a result of cancer. Based on the clinical efficacy, gallium nitrate injections (GaniteTM) was granted approval by the FDA for the treatment of cancer-associated hypercalcaemia. Gallium nitrate is also believed to inhibit the bone turnover and therefore to decrease osteolysis, the active reabsorption of bone material, in patients with bone metastasis secondary to other cancers.

Galliumtrinitrat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Galliumtrinitrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 51)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40269 62
Alfa Aesar 400-610-6006; 021-67582000
021-67582001/03/05 saleschina@alfa-asia.com China 30163 84
Shanghai Sunway Pharmaceutical Technology Co., Ltd +86 (21) 51613915
+86 (21) 51613951 sales@sunwaypharm.com China 9894 57
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397 waley188@sohu.com China 12341 58
HBCChem, Inc. +1-510-219-6317
+1-650-486-1361 sales@hbcchem.com United States 10661 60
Forsman Scientific ( Beijing ) Co., Ltd. +86-10-6464 6565
+86-10-6464 6568 info@forsman.com.cn;salesd@forsman.com.cn China 691 58
Ganzhou Jiayuan Advanced Materials Co.,Ltd. 0797-2196836
hong.qi@jiaton.com China 199 55
Shandong XiYa Chemical Industry Co., Ltd 4008-626-111
0539-6365991 3229735657@qq.com China 26779 60
Guangdong wengjiang Chemical Reagent Co., Ltd. 13927870750 0751-2886750
0751-2886756 QQ:3001264886 3001264886@qq.com China 14310 58

13494-90-1(Galliumtrinitrat)Verwandte Suche:


  • gallium(iii)nitrate(1:3)
  • galliumtrinitrate
  • ganite
  • nitricacid,gallium(3+)salt
  • Nitricacid,galliumsalt
  • nsc-15200
  • Gallium(Ⅲ) nitrate
  • GALLIUM NITRATE, 99.9%
  • GALLIUM NITRATE, 99.999%
  • GALLIUM (III) NITRATE
  • GALLIUM NITRATE
  • Gallium(III) nitrate solution, Ga 9-10% w/w
  • Trinitric acid gallium salt
  • Ga(NO3)3nH2O
  • Wln: ga N-o3*3
  • Gallium(III) nitrate solution, 9-10 wt. % in water
  • GalliuM(III) nitrate solution, Ga
  • 13494-90-1
  • GaNO33xH2O
  • GaN3O9
  • GaNO3
  • GaNO33
  • 2557347
  • Catalysis and Inorganic Chemistry
  • Gallium
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