Pomalidomide

Pomalidomide Struktur
19171-19-8
CAS-Nr.
19171-19-8
Englisch Name:
Pomalidomide
Synonyma:
4-AMino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;CC-4047;Pomadomide;Pomalidomide-d4;PomaL;IMiD 3;CS-388;ActiMid;Pomalidomide;3-dioxo-2-(2
CBNumber:
CB32128749
Summenformel:
C13H11N3O4
Molgewicht:
273.24
MOL-Datei:
19171-19-8.mol

Pomalidomide Eigenschaften

Schmelzpunkt:
318.5 - 320.5°
Siedepunkt:
582.9±45.0 °C(Predicted)
Dichte
1.570±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
DMSO: ≥14mg/mL
pka
10.75±0.40(Predicted)
Aggregatzustand
powder
Farbe
yellow
Merck 
14,135
Stabilität:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI
InChI=1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)
InChIKey
UVSMNLNDYGZFPF-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C(N)=CC=C2)C(=O)N1C1CCC(=O)NC1=O

Sicherheit

WGK Germany  3
RTECS-Nr. NR3397905
HS Code  29251900
Giftige Stoffe Daten 19171-19-8(Hazardous Substances Data)

Pomalidomide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

In February 2013, the US FDA approved pomalidomide (also known as CC4047) for the treatment of multiple myeloma (MM) in patients with disease progression after receiving other cancer therapeutics. Pomalidomide is a 4-amino analog of thalidomide with enhanced potency and an improved toxicity profile. Pomalidomide and thalidomide exert their effects by modulation of immunity, inhibition of angiogenesis, interference with the bone/tumor microenvironment, and inhibition of the cereblon protein. Pomalidomide potently inhibited in vitro proliferation in a variety of human MM cell lines, IC50~10 nM, while thalidomide showed almost no inhibition up to 100 μM. In mouse MM tumor models, 50 mg/kg daily doses of pomalidomide resulted in marked inhibition of tumor growth after 15 days of treatment and complete regression in 3–6 weeks versus thalidomide-treated controls at the same dose. Pomalidomide is prepared by condensation of 4-nitrophthalic anhydride with 3-aminopiperidine-2,6-dione followed by catalytic hydrogenation of the nitro group.

Chemische Eigenschaften

Yellow Solid

Verwenden

Pomalidomide inhibits LPS-induced TNF-α release with IC50 of 13 nM

Definition

ChEBI: An aromatic amine that is thalidomide substituted at position 4 on the isoindole ring system by an amino group. Used for the treatment of multiple myeloma in patients who failed to respond to previous therapies.

Pomalidomide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pomalidomide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 492)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Beijing Mesochem Technology Co.,Ltd
+8613651027935
rachel@mesochem.com China 191 58
shandong perfect biotechnology co.ltd
+86-53169958659; +8618596095638
sales@sdperfect.com China 294 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2504 58
Shaanxi Haibo Biotechnology Co., Ltd
+86-02963020060 +86-18629295024
hibo06@xaltbio.com China 1000 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806
sales@capotchem.com China 29797 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21700 55
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714
fandachem@gmail.com China 9354 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3012 60
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@
sales03@shyrchem.com CHINA 738 60

19171-19-8()Verwandte Suche:


  • 4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
  • Pomalidomide
  • Pomalidomide(CC-4047)
  • ActiMid
  • 1H-Isoindole-1,3(2H)-dione,4-aMino-2-(2,6-dioxo-3-piperidinyl)-
  • Pomalidomide(CC-4047,Actimid)
  • 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline
  • 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide
  • 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
  • IMiD 3
  • Pomalidomide, >=99%
  • Pomalidomid,4-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
  • pomalidomide,Pomalyst
  • Actimid (Celgene)
  • 3-dioxo-2-(2
  • 6-dioxopiperidin-3-yl)-4-aminoisoindoline
  • Pomalidomide high quality
  • 4-Amino-2-(2,6-dioxo-3-piperidinyl)isoindole-1,3-dione
  • CS-388
  • 4-Amino-2-(2,6-dioxo-piperidin-3-yl)-1H-isoindol-1,3(2H)-dione
  • 4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
  • Pomalidomide high quality 19171-19-8
  • Pomalidomide, 99%, a inhibitor of TNF-α
  • Pomalidomide>
  • PomaL
  • Pomalidomide USP/EP/BP
  • CC-4047
  • 4-AMino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
  • Pomalidomide-d4
  • Pomadomide
  • Pomaduramide
  • QTARK(Me3)T-PEG4-Acp-Pomalidomide /Pomalidomide
  • Pomalidomide (CC4047 or actimid)
  • 19171-19-8
  • Inhibitor
  • Inhibitors
  • CC-4047
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