PNU 100480
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- CAS-Nr.
- 168828-58-8
- Englisch Name:
- PNU 100480
- Synonyma:
- CS-2604;U-100480;Sutezolid;PNU 100480;PF-02341272;Sutezolid 13C4;Sutezolid (PNU-100480);Sutezolid >=98% (HPLC);PNU-100480; U-100480; PF-02341272;Sutezolid (PNU-100480, PF-02341272)
- CBNumber:
- CB32628274
- Summenformel:
- C16H20FN3O3S
- Molgewicht:
- 353.41
- MOL-Datei:
- 168828-58-8.mol
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PNU 100480 Eigenschaften
- Schmelzpunkt:
- 186-187°C
- Siedepunkt:
- 609.0±55.0 °C(Predicted)
- Dichte
- 1.321±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- Löslichkeit
- DMSO: soluble20mg/mL, clear
- Aggregatzustand
- powder
- pka
- 15.53±0.46(Predicted)
- Farbe
- white to beige
- Optische Aktivität
- [α]/D -8 to -12°, c = 1 in chloroform-d
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
22 |
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| S-Sätze: |
45 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
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PNU 100480 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis. It inhibits the growth of
M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid , rifampin (rifampicin; ), ethambutol , and streptomycin (; MICs = ≤0.0625-0.5 mg/L). It also inhibits the growth of
P. insidiosum and
P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml). PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating
M. tuberculosis infection.
Verwenden
Sutezolid is an oxazolidinone antibacterial agent analog. Sutezolid is a promising antimycobacterial agent (tuberculostatic).
Biochem/physiol Actions
Sutezolid (PNU 100480) is an oxazolidinone antimicrobial. Sutezolid inhibits protein synthesis by inhibiting bacterial mRNA translation. Sutezolid is being investigated for the treatment of multiple drug–resistant and extensively drug-resistant tuberculosis. The compound is a less toxic and more potent derivative of linezolid.
PNU 100480 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PNU 100480 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 65)Lieferanten
- PNU 100480
- (S)-N-[[3-[3-Fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide
- Sutezolid
- (S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
- (S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide(WXC06631)
- PF-02341272
- Sutezolid (PNU-100480, PF-02341272)
- PNU-100480; U-100480; PF-02341272
- U-100480
- PNU 100480 - PF 02341272 | U 100480 | Sutezolid
- CS-2604
- Sutezolid (PNU-100480)
- Acetamide, N-[[(5S)-3-[3-fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-
- Sutezolid >=98% (HPLC)
- N-[[(5S)-3-(3-fluoro-4-thiomorpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
- Sutezolid 13C4
- U 100480,oxazolidinone,Antibiotic,protein,Sutezolid,synthesis,Bacterial,Inhibitor,PF 02341272,inhibit,PF02341272,U100480,antimicrobial,tuberculosis,PNU 100480,PNU100480
- N-({(5S)-3-[3-Fluoro-4-(4-thiomorpholinyl)phenyl]-2-oxo-1,3- oxazolidin-5-yl}methyl)acetamide
- 168828-58-8
