Nadifloxacin
|
|
|
- CAS-Nr.
- 124858-35-1
- Englisch Name:
- Nadifloxacin
- Synonyma:
- NDFX;Acuati;Acuatim;opc7251;Nadiflo;Nafloxacin;Nadiroxisan;Jinofloxacin;NADIFLOXACIN;Nadifiloxacin
- CBNumber:
- CB3301560
- Summenformel:
- C19H21FN2O4
- Molgewicht:
- 360.38
- MOL-Datei:
- 124858-35-1.mol
|
Nadifloxacin Eigenschaften
- Schmelzpunkt:
- 245-2470C (dec)
- Siedepunkt:
- 624.9±55.0 °C(Predicted)
- Dichte
- 1.46±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- Löslichkeit
- DMSO (Slightly), Methanol (Sparingly, Heated)
- Aggregatzustand
- White to yellow crystalline solid.
- pka
- 5.55±0.40(Predicted)
- Farbe
- White to Off-White
- Merck
- 14,6345
- InChI
- InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)
- InChIKey
- JYJTVFIEFKZWCJ-UHFFFAOYSA-N
- SMILES
- C12=CC(F)=C(N3CCC(O)CC3)C3=C1N(C(C)CC3)C=C(C(O)=O)C2=O
- CAS Datenbank
- 124858-35-1(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| HS Code |
2933.99.7500 |
|
|
| Toxizität |
LD50 male, female mice and rats (mg/kg): 376.5, 420.6, 225.7, 240.5 i.v. (Hashimoto) |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
|
|
| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
|
Nadifloxacin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Nadifloxacin, one of the three new fluoroquinolone antibiotics launched in 1993 is
indicated for topical treatment of acne vulgaris and other skin infections. Nadifloxacin has a
potent and broad spectrum of activity against aerobic Gram-positive and -negative bacteria
and against anaerobic bacteria. It produces significant improvement in patients with
Propionibacterium acnes infection and does not appear to cause cross-resistance to other
antibiotic agents. Its potent antimicrobial activity has also been demonstrated in the
Pseudomonas aeruginosa burn wound infection model in mice. Nadifloxacin exerts its
antibiotic activity by inhibiting the formation of supercoiled DNA by DNA gyrase.
Chemische Eigenschaften
Off-White Crystalline Solid
Verwenden
Nadifloxacin is a topical fluorinated quinolone antibacterial used to treat skin conditions such as acne and other dermal infections caused by bacteria. This drug belongs to a class of calcium salt of polyacrylic acid crosslinked with divinyl glycol with minimal AEs.
Definition
ChEBI: Nadifloxacin is a pyridoquinoline, a hydroxypiperidine, a heteroarylpiperidine and a quinolone antibiotic. It has a role as an antibacterial drug. It is effective against the Gram-positive bacteria S. aureus and P. acnes, as well as Gram-negative bacteria.
Pharmazeutische Anwendungen
A lipophilic tricyclic fluorobenzoquinoline with a 4- hydroxylpiperinyl moiety at the C-8 position, formulated as a cream for topical use. It is active against many Grampositive bacteria involved in skin infections, including Propionibacterium acnes (MIC 0.25–2.0 mg/L), and Staph. aureus (MIC 0.015–2 mg/L). It appears to inhibit the generation of reactive oxygen species by neutrophils. The sodium salt is used as a 1% cream for use in acne vulgaris and cutaneous staphylococcal infections.
Nadifloxacin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Nadifloxacin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 280)Lieferanten
124858-35-1()Verwandte Suche:
- NDFX
- Nadifiloxacin
- NadifloxacinAPI
- 7-fluoro-8-(4-hydroxypiperidin-1-yl)-12-Methyl-4-oxo-1-azatricyclo[7.3.1.0^{5,13}]trideca-2,5(13),6,8-tetraene-3-carboxylic acid
- 9-Fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid
- NADIFLOXACIN
- 9-Fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic Acid
- Acuati
- Jinofloxacin
- 1H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo- (9CI)
- 1H,5H-Benzo[ij]quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-, (+-)-
- Acuatim
- (+/-)-9-fluoro-6,7-dihydro-8-(4-hydroxypiperidino)-5-methyl-1-oxo-1h,5h-benzo[ij]quinolizine-2-carboxylic acid
- opc7251
- Nadiflo
- Nadiroxisan
- Nadifloxacin D5
- NadifloxacinQ: What is
Nadifloxacin Q: What is the CAS Number of
Nadifloxacin Q: What is the storage condition of
Nadifloxacin
- Nadifloxacin impurities1235
- 9-Fluoro-8-(4-hydroxypiperidin-1-yl)-5-methyl-1-oxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic acid
- Nadifloxacin USP/EP/BP
- 9-Fluoro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-1,5,6,7-tetrahydropyrido[3,2,1-ij]quinoline-2-carboxylic Acid
- Nadifloxacin>
- (+/-)-9-Fluoro-6,7-dihydro-8-(4-hydroxypiperidino)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid
- The effect of the fluorine
- Nafloxacin
- 124858-35-1
- C19H21FN2O4
- ACUATIM
- Intermediates & Fine Chemicals
- Pharmaceuticals
