Schisandrin

Schisandrin Struktur
7432-28-2
CAS-Nr.
7432-28-2
Englisch Name:
Schisandrin
Synonyma:
SCHISANDROL A;SCHIZANDRIN;SCHIZANDROL A;Schisandrol;SCHIZANDROL;12aR)-;schizandra;SCHISANDRIN;Schisadrol A;Schizandrin std.
CBNumber:
CB3334838
Summenformel:
C24H32O7
Molgewicht:
432.51
MOL-Datei:
7432-28-2.mol

Schisandrin Eigenschaften

Schmelzpunkt:
128.5°C
Siedepunkt:
466.17°C (rough estimate)
Dichte
1.1480 (rough estimate)
Brechungsindex
1.5800 (estimate)
storage temp. 
2-8°C
Löslichkeit
DMSO: ≥13mg/mL
Aggregatzustand
powder
pka
14.58±0.40(Predicted)
Farbe
white to beige
Optische Aktivität
[α]/D 75 to 95°, c = 1 in methanol
InChIKey
YEFOAORQXAOVJQ-UHFFFAOYSA-N
LogP
3.153 (est)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,N
R-Sätze: 22-50/53
S-Sätze: 60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
HS Code  29093090
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H400 Sehr giftig für Wasserorganismen. Kurzfristig (akut) gewässergefährdend Kategorie 1 Warnung GHS hazard pictogramssrc="/GHS09.jpg" width="20" height="20" /> P273, P391, P501
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.

Schisandrin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities. It induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM. Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells. It reduces apoptosis induced by cisplatin in HK-2 human kidney cells. In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats. It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.

Verwenden

Schizandrin may be used in oxidative stress-related cell signaling studies.

Application

Schizandrin is a natural compound that belongs to the group of schisandrins. Schizandrins are a class of compounds with biochemical properties and biological activities, such as anti-inflammatory, antioxidant, and anti-cancer effects. This compound has been shown to have pro-apoptotic properties in a model system. It has also demonstrated the ability to inhibit influenza A virus replication in vitro and protect mice against Listeria monocytogenes infection. It can be used as an inhibitor of gsh-px activity in myocardial infarcts.

Biochem/physiol Actions

Schizandrin is a natural product with several biological properties involved with antioxidant and anti-inflammatory activities. It reduces the formation of ROS, inhibits the mitochondrial pathway of the apoptotic process and oxidative stress. Schizandrin has been reported to have hepatoprotective, antitumor, antiviral, and antiamnesic effects, and has neuroprotective activity against glutamate induced neurotoxicity.

Schisandrin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Schisandrin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 291)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897
sales@biopurify.com China 3424 58
Henan Tengmao Chemical Technology Co. LTD
+8615238638457
salesvip2@hntmhg.com China 415 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21691 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3620 58
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Chengdu GLP biotechnology Co Ltd
028-87075086 13350802083
scglp@glp-china.com CHINA 1824 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
+8613815430202
sale02@cqherb.com CHINA 376 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58

7432-28-2()Verwandte Suche:


  • Schisandrin,Schizandrin
  • chisandrin 5,6,7,8-Tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxydibenzo[a,c]cycloocten-6-ol
  • Schizandrin, >=98%
  • SCHISANDRIN
  • WUWEIZI ALCOHOL A
  • SCHISANDRIN (SCHISANDROL A)
  • Schizandrin std.
  • Schisandrin(Schizandrol A)
  • Schisadrol A
  • dibenzo(a,c)cycloocten-6-ol,5,6,7,8-tetrahydro-6,7-dimethyl-1,23,10,11,12-hex
  • schizandra
  • 5,6,7,8-Tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxydibenzo[a,c]cycloocten-6-ol
  • (+)-Schizandrin Schisandrin Schisandrine Wuweizi alcohol A Schizandrin
  • 1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-,(6S,7S
  • 12aR)-
  • Dibenzo[a,c]cycloocten-6-ol, 5,6,7,8-tetrahydro-
  • 5,6,7,8-Tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyldibenzo[a,c]cycloocten-6-ol
  • Schizandrin, 98%, from Schisandra chinensis (Turcz.) Baill.
  • Schisandrae Berry Extract
  • Schisandrol A 7432-28-2
  • Schisandrin (Schizandrol
  • Dibenzo[a,c]cycloocten-6-ol, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (6S,7S,12aR)-
  • hot selling Schisandra Berries P.E
  • DeoxyschizandrinSchisandra chinensis extract
  • (6S,7S,12aR)-1,2,3,10,11,12-Hexamethoxy-6,7-dimethyl-5,6,7,8-tetrahydrodibenzo[a,c][8]annulen-6-ol
  • SCHIZANDROL
  • SCHIZANDROL A
  • SCHIZANDRIN
  • SCHISANDROL A
  • Schisandrol
  • Abametapir Impurity 29
  • Schisandrin methyl
  • 7432-28-2
  • C24H32O7
  • Inhibitors
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Miscellaneous Natural Products
  • Natural Plant Extract
  • chemical reagent
  • pharmaceutical intermediate
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