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Topotecan hydrochloride Produkt Beschreibung

Topotecan hydrochloride Struktur
119413-54-6
CAS-Nr.
119413-54-6
Englisch Name:
Topotecan hydrochloride
Synonyma:
Hycamtin;NSC 609669;Levulan-13C;SKF-104864A;SKFS 104864A;Nogitecan HCl;5-ALA HCl-13C;TOPOTECAN HCL;HYDROCHLORIDE;SKF-S 104864-A
CBNumber:
CB3361775
Summenformel:
C23H24ClN3O5
Molgewicht:
457.91
MOL-Datei:
119413-54-6.mol

Topotecan hydrochloride Eigenschaften

Schmelzpunkt:
213-218°C
storage temp. 
Refrigerator
Aggregatzustand
Light yellow to greenish powder.
CAS Datenbank
119413-54-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher T
R-Sätze: 25-36/37/38-46
S-Sätze: 26-36/37/39-45
HS Code  29420000

Topotecan hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R46:Kann vererbbare Schäden verursachen.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Chemische Eigenschaften

White Crystalline Solid

Verwenden

Naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer)

Verwenden

antineoplastic; topoisomerase I inhibitor

Verwenden

A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.

Trademarks

Topotecan is INN and BAN.

Allgemeine Beschreibung

Topotecan is supplied in 4-mg vials and administered IV forthe treatment of ovarian cancer, cervical cancer, and smallcell lung cancer in those patients who did not respond tofirst-line therapy. Following IV administration, the drug iswidely distributed with 10% to 35% of the agent bound toplasma proteins. There is evidence that the agent may crossthe blood-brain barrier to some extent. In plasma, an equilibriumis established between the lactone and the less activehydroxy acid with 20% of the drug present as the lactone 1hour after the infusion is complete. In contrast to irinotecan,both the lactone and the hydroxy acid bind equally well tohuman serum albumin. N-Demethylation of the tertiaryamine to give the secondary amine is mediated by CYP3A4and represents a minor route of metabolism. Glucuronidationof the parent and the phase I metabolites also occurs to a limited(10%) extent.Elimination occurs primarily in theurine, with 30% of the dose being recovered as unchangeddrug. The terminal elimination half-life is 2 to 3 hours. Themajor toxicity seen for topotecan is dose-limiting myelosuppression.Nausea and vomiting are seen in most (70%–80%)patients, along with diarrhea and abdominal pain. Other toxicitiesinclude headache myalgias, alopecia and elevation ofserum transaminases, alkaline phosphatases, and bilirubin.Microscopic hematuria (blood in the urine) may also be seen.

Topotecan hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Topotecan hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 296)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21792 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22631 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1365 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30057 58
Chengdu GLP Biotech Co., Ltd
13350802083
scglp@glp-china.com CHINA 1008 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 969 58
Chengdu Biopurify Phytochemicals Ltd.
18080483897
maggie@biopurify.com CHINA 2368 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23978 58

119413-54-6()Verwandte Suche:


  • 10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride
  • 2-(3-Chloro-5-trifluoromethyl-pyridin-2-yl)-ethylamine
  • 2-(3-Fluoro-benzylsulfanyl)-ethylamine
  • Ritonavir Impurity (2S,3S,5S)-5-Amino-1,6-diphenyl-2-([[thiazol-5-ylmethoxy)carbonyl]amino]hexan-3-yl 2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoate�
  • N-methyl-5-azaspiro(2.3)hexane-2-carboxamide
  • Hycamtin
  • Nogitecan hydrochloride
  • Topotecan hydrochloride
  • (S)-10-((diMethylaMino)Methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride
  • 2-Aza-bicyclo[4.1.0]heptane(HCl):2-Aza-bicyclo[4.1.0]heptane
  • (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, hydrochloride (1:1)
  • Nogitecan HCl
  • Topotecan Hydrochloride Labeled d6
  • Topotecan hydrochloride, >=99%
  • N-(oxolan-2-ylmethyl)-2-(propan-2-ylamino)acetamide
  • 2-[5-(1-ethylpyrazol-4-yl)-1,3,4-oxadiazol-2-yl]ethanamine
  • (1S,5R)-3,3-difluoro-8-azabicyclo[3.2.1]octane
  • 5-ALA HCl-13C
  • 5-Amino-4-oxopentanoic Acid-13C
  • 5-Aminolevulinic Acid-3-13C Hydrochloride
  • Aminolevulinic-13C Acid Hydrochloride
  • d-Aminolevulinic-13C Acid Hydrochloride
  • Levulan-13C
  • 4-(2-Oxo-butyl)-benzamidine
  • methyl 3-methyl-2-(methylamino)butanoate
  • {3-[4-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-pyrazol-1-yl]-azetidin-3-yl}-acetonitrile
  • N-[[4-[(6-chloropyridin-3-yl)methoxy]-3-methoxyphenyl]methyl]-2-(3,4-dimethoxyphenyl)ethanamine
  • (2R)-2-amino-3-(3-methylimidazol-4-yl)propanoic acid
  • C-(5-m-Tolyl-[1,3,4]oxadiazol-2-yl)-methylamine
  • C-(5-p-Tolyl-[1,3,4]oxadiazol-2-yl)-methylamine
  • C-[5-(3-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-methylamine
  • C-[5-(3-Fluoro-phenyl)-[1,3,4]oxadiazol-2-yl]-methylamine
  • C-[5-(3-Methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-methylamine
  • C-[5-(3-Nitro-phenyl)-[1,3,4]oxadiazol-2-yl]-methylamine
  • C-[5-(3-Trifluoromethoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-methylamine
  • C-[5-(3-Trifluoromethyl-phenyl)-[1,3,4]oxadiazol-2-yl]-methylamine
  • C-[5-(4-Chloro-phenyl)-[1,3,4]oxadiazol-2-yl]-methylamine
  • C-[5-(4-Fluoro-phenyl)-[1,3,4]oxadiazol-2-yl]-methylamine
  • C-[5-(4-Methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-methylamine
  • C-[5-(4-Nitro-phenyl)-[1,3,4]oxadiazol-2-yl]-methylamine
  • C-[5-(4-Thiophen-2-yl-phenyl)-[1,3,4]oxadiazol-2-yl]-methylamine
  • C-[5-(4-Trifluoromethoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-methylamine
  • C-[5-(4-Trifluoromethyl-phenyl)-[1,3,4]oxadiazol-2-yl]-methylamine
  • Methyl 2-(2-Chloro-4-(3-chloro-2-hydroxy-5-iodobenzamido)-5-methylphenyl)-2-(4-chlorophenyl)acetimidate�
  • TOPOTECAN MONOHYDROCHLORIDE
  • TOPOTECAN HCL
  • SKF-104864A
  • 9-[(DIMETHYLAMINO)METHYL]-10-HYDROXY-(20S)-CAMPTOTHECIN, HCL
  • (4S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4',6-7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)-DIONE
  • HYDROCHLORIDE
  • topetecan hydrochloride
  • 5-PIPERAZIN-1-YL-BENZOFURAN-2-CARBOXYLIC ACID ETHYL ESTER
  • (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[346-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, Hydrochloride, SKF-104864A,
  • 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (4S)- (9CI)
  • 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-, monohydrochloride, (S)-
  • NSC 609669
  • SKFS 104864A
  • SKF-S 104864-A
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