DOXACURIUM CHLORIDE

DOXACURIUM CHLORIDE Struktur
106819-53-8
CAS-Nr.
106819-53-8
Englisch Name:
DOXACURIUM CHLORIDE
Synonyma:
Nuromax;Doxacurium;BW-A938U;DOXACURIUM CHLORIDE;DOXACURIUM CHLORIDE USP/EP/BP;bis[3-[6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1h-isoquinolin-2-ium-2-yl]propyl] butanedioate dichloride
CBNumber:
CB3366932
Summenformel:
C56H78Cl2N2O16
Molgewicht:
1106.13
MOL-Datei:
106819-53-8.mol

DOXACURIUM CHLORIDE Eigenschaften

Sicherheit

DOXACURIUM CHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Doxacurium chloride is an injectable, noncumulative, nondepolarizing neuromuscular blocking agent which exhibits no significant cardiovascular effects. It is a mixture of (lR, l′S, 2S, 2′R), (lR, l′R, 2S, 2′s) and (lS, l′S, 2R, 2′R) isomers of a bis-benzylisoquinolinium diester.Doxacurium chloride provides satisfactory intubation with duration of action similar to d-tubocurarine or pancuronium. However, it is reported to be 2 to 3 times as potent as pancuronium.

Verwenden

Doxacurium Chloride is a nondepolarizing neuromuscular blocking agent that is minimally hydrolyzed by human plasma cholinesterase.

Allgemeine Beschreibung

The molecular structure of doxacuriumchloride, 1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy2-methyl-1-(3,4,5-trimethoxybenzyl) isoquinoliniumchloride succinate (Nuromax), provides thepossibility for 10 stereoisomers: 4 d,l pairs and two mesoforms. Of the 10 stereoisomers, 3 are all-trans configuration,and these are the only active ones. Doxacurium chlorideis a long-acting nondepolarizing blocking agent. The drugdiffers from drugs such as gallium and pancuronium in thatit has no vagolytic activity. It is used as a skeletal musclerelaxant in surgical procedures expected to last longer than90 minutes.

Pharmakokinetik

Doxacurium is a mixture of three trans, trans-stereoisomers, a dl pair [(1R,1′R,2S,2′S) and (1S,1′S,2R,2′R)] and a meso form (1R,1′S,2S,2′R). Doxacurium is hydrophilic, has a small volume of distribution, and is distributed primarily to extracellular fluids. It is not metabolized by plasma cholinesterase or hepatic enzymes and does not undergo Hofmann elimination.

DOXACURIUM CHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


DOXACURIUM CHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 36)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Changzhou Rokechem Technology Co., Ltd.
18758118018
sales001@rokechem.com China 255 58
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
bruce@xrdchem.cn CHINA 566 55
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23556 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29831 58
AFINE CHEMICALS LIMITED
0571-85134551
info@afinechem.com CHINA 15377 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418684 +8618949823763
sales@tnjchem.com China 25363 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49739 58
Protheragen-ING
+16313385890
info@protheragen-ing.com United States 528 58
Hubei jian chu biological technology co., LTD 027-027-65021350 18164064948
y18164064948@163.com China 552 58

106819-53-8()Verwandte Suche:


  • DOXACURIUM CHLORIDE
  • BW-A938U
  • bis[3-[6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1h-isoquinolin-2-ium-2-yl]propyl] butanedioate dichloride
  • DOXACURIUM CHLORIDE USP/EP/BP
  • Doxacurium
  • Nuromax
  • 106819-53-8
  • C56H78Cl2N2O16
Copyright 2019 © ChemicalBook. All rights reserved