6,7-Dihydro-1,2,3,10-tetramethoxy-7-methylamino-benzo(a)heptalen-9(5H)-on

DEMECOLCINE Struktur
477-30-5
CAS-Nr.
477-30-5
Bezeichnung:
6,7-Dihydro-1,2,3,10-tetramethoxy-7-methylamino-benzo(a)heptalen-9(5H)-on
Englisch Name:
DEMECOLCINE
Synonyma:
COLCEMID;COLCHAMINE;(S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one;omain;Osamin;omaine;C-12669;nsc3096;Colcemide;ColchaMin
CBNumber:
CB3460085
Summenformel:
C21H25NO5
Molgewicht:
371.43
MOL-Datei:
477-30-5.mol

6,7-Dihydro-1,2,3,10-tetramethoxy-7-methylamino-benzo(a)heptalen-9(5H)-on Eigenschaften

Schmelzpunkt:
73-75°C
alpha 
D20 -129.0° (c = 1 in chloroform)
Siedepunkt:
501.11°C (rough estimate)
Dichte
1.2350 (rough estimate)
Brechungsindex
1.5614 (estimate)
storage temp. 
2-8°C
Löslichkeit
DMSO: 10 mg/mL
Aggregatzustand
powder
pka
8.48±0.40(Predicted)
Sensitive 
Air & Light Sensitive
BRN 
2822892
Stabilität:
Hygroscopic
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T,T+
R-Sätze: 25-26/27/28
S-Sätze: 22-24/25-45-36/37/39
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS-Nr. GH0800000
8-10-23
HazardClass  6.1(a)
PackingGroup  II
Toxizität LD50 oral in mouse: 25530ug/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizität oral Kategorie 2 Achtung P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

6,7-Dihydro-1,2,3,10-tetramethoxy-7-methylamino-benzo(a)heptalen-9(5H)-on Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R25:Giftig beim Verschlucken.
R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Beschreibung

Colcemid is a colchicine derivative that inhibits tubulin polymerization as potently as colchicine (IC50 = 2.1 and 2.4 μM, respectively) but is less toxic. At very low (nanomolar) concentrations, colcemid suppresses microtubule dynamicity and inhibits cell migration, while at micromolar levels it blocks microtubule assembly, arresting cells in metaphase. Mitotic block by colcemid is used to synchronize cells and for karyotyping in cytogenetic studies. Prolonged exposure to colcemid can activate p53, leading to apoptosis.

Chemische Eigenschaften

Faintly Yellow Crystalline Powder

Verwenden

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

Definition

ChEBI: A secondary amino compound that is (S)-colchicine in which the N-acetyl group is replaced by an N-methyl group. Isolable from the autumn crocus, Colchicum autumnale, it is less toxic than olchicine and is used as an antineoplastic.

Allgemeine Beschreibung

Colcemid is also known as demecolcine. Its generic name is N-methyl-N-deacetyl-colchicine. Colcemid depolymerizes microtubules and blocks mitosis at metaphase.

Sicherheitsprofil

Poison by ingestion, intraperitoneal, parenteral, intravenous, and intramuscular routes. Human systemic effects by ingestion: (skin and appendages) hair effects. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.

läuterung methode

Colcemide is purified by chromatography on silica and eluting with CHCl3/MeOH (9:1), and by recrystallisation from EtOAc/Et2O to form yellow prisms. UV in EtOH has max 243nm ( 30,200) and 350nm ( 16,3000). [Synthesis, IR, NMR, MS: Capraro & Brossi Helv Chim Acta 62 965 1979, Beilstein 8 IV 3319.]

6,7-Dihydro-1,2,3,10-tetramethoxy-7-methylamino-benzo(a)heptalen-9(5H)-on Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


6,7-Dihydro-1,2,3,10-tetramethoxy-7-methylamino-benzo(a)heptalen-9(5H)-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 126)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22968 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29826 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569266 15319487004
1015@dideu.com China 2263 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Wuhan Monad Medicine Tech Co.,LTD
02768782018 18771942761
sales01@whmonad.com CHINA 992 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23556 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29831 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com CHINA 52867 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 50001 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501
product@acmec-e.com China 33349 58

477-30-5(6,7-Dihydro-1,2,3,10-tetramethoxy-7-methylamino-benzo(a)heptalen-9(5H)-on)Verwandte Suche:


  • substancef
  • Colcemide
  • DEMECOLCINE HYBRI-MAXR
  • Colcemid-D3=Demecolcine-D3
  • N-Deacetyl-N-methyl(deutero)colchicine
  • COLCEMIDE(R)
  • COLCEMID(R)
  • DEMECOLCIN
  • DEMECOLCINE
  • Benzoaheptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (7S)-
  • COLCHICINE,N-DEACETYL-N-METHYL-
  • DEMECOLCINE/COLCEMIDE/COLCHICINE
  • N-Deacetyl-N-methylcolchicine, Colcemid
  • ColcemidTM solution, N-Deacetyl-N-methylcolchicine solution
  • Demecolcine solution
  • C-12669
  • Osamin
  • Demecolcine,N-Deacetyl-N-methylcolchicine
  • Colcemid, Demecolcine
  • (7S)-6,7-Dihydro-1,2,3,10-tetraMethoxy-7-(MethylaMino)-benzo[a]heptalen-9(5H)-one
  • ColchaMin
  • 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-benzo(alpha)heptalen-9(5h)
  • 7-deacetamido-7-(methylamino)-colchicin
  • alkaloidh3,fromcolchicumantumnale
  • benzo(a)heptalen-9(5h)-one,6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)
  • ciba12669a
  • deacetylmethylcolchicine
  • deacetyl-n-methyl-colchicin
  • deacetyl-n-methylcolchicine
  • desmecolcine
  • kolchamin
  • kolchicin
  • n-deacetyl-n-methyl-colchicin
  • n-desacetylmethylcolchicine
  • n-methyl-n-desacetylcolchicine
  • nsc3096
  • omain
  • omaine
  • reichstein’sf
  • santavy’ssubstancef
  • N-DEACETYL-N-METHYLCOLCHICINE
  • N-DESACETYL-N-METHYLCOLCHICINE
  • N-METHYL-N-DEACETYL-COLCHICINE
  • DEMECOLCINE SOLUTION 10 UG/ML
  • Colcemid - CAS 477-30-5 - Calbiochem
  • Colchicine N-Methyl Analog
  • (-)-demecolcine
  • DEMECOLCINE USP/EP/BP
  • Decarbonylation colchicine
  • Demecolcine, ≥98%+
  • Tropisetronum
  • Tropisteron
  • COLCEMID
  • COLCHAMINE
  • (S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one
  • Colchicine Impurity 23
  • Chelidonine Impurity?3
  • 477-30-5
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