InSolution p38 MAP Kinase Inhibitor III - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A cell-permeable, potent, selective, and ATP-competitive inhibitor of p38 MAP kinase (IC
50 = 380 nM for p38α). Shown to effectively suppress LPS-induced cytokine release in vitro (IC
50 = 160 nM for TNF-α release and 39 nM for IL-1β release, human PBMC) and
in vivo (ED
50 = 1.33 mg/kg for TNF-α release in mice). Exhibits reduced inhibitory activity against cytochrome P450-2D6 compared to SB 203580 (Cat. No 559389) and is better suited for use in animal models.
Biochem/physiol Actions
Cell permeable: yes
InSolution p38 MAP Kinase Inhibitor III - Calbiochem Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte