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Phytomenadion Produkt Beschreibung

Vitamin K1 Struktur
84-80-0
CAS-Nr.
84-80-0
Bezeichnung:
Phytomenadion
Englisch Name:
Vitamin K1
Synonyma:
kativn;K-Ject;Kaywan;Orakay;Kephton;2',3'-t;Kativ N;Veda K1;Veta K1;K1VitaM
CBNumber:
CB3482555
Summenformel:
C31H46O2
Molgewicht:
450.7
MOL-Datei:
84-80-0.mol

Phytomenadion Eigenschaften

Schmelzpunkt:
−20 °C(lit.)
alpha 
D25 -0.28° (dioxane)
Siedepunkt:
140°C 0mm
Dichte
0.984 g/mL at 25 °C(lit.)
Brechungsindex
n20/D 1.527(lit.)
Flammpunkt:
>230 °F
storage temp. 
2-8°C
Aggregatzustand
viscous liquid
Wichte
0.984
Wasserlöslichkeit
Miscible with dehydrated alcohol, acetone, petroleum ether, hexane, dioxane, chloroform, ether, benzene and vegetable oils. Immiscible with water.
Sensitive 
Light Sensitive
Merck 
14,7380
BRN 
2568816
InChIKey
MBWXNTAXLNYFJB-LKUDQCMESA-N
CAS Datenbank
84-80-0(CAS DataBase Reference)
NIST chemische Informationen
Phytonadione(84-80-0)
EPA chemische Informationen
Phylloquinone (84-80-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xi
R-Sätze: 36/37/38
S-Sätze: 26-37/39-24/25
RIDADR  UN1170 - class 3 - PG 2 - Ethanol, solution
WGK Germany  2
RTECS-Nr. QJ5800000
1-8-10
TSCA  Yes
HS Code  29362900
Giftige Stoffe Daten 84-80-0(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P337+P313 Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P403+P235 An einem gut belüfteten Ort aufbewahren. Kühl halten.

Phytomenadion Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Beschreibung

Vitamin K1 is a fat-soluble, dietary nutrient that is essential for the synthesis of proteins important for blood-clotting, bone metabolism, and cell growth. It is found in the photosynthetic tissues of green, leafy plants, where it acts as an electron acceptor forming part of the electron transport chain of Photosystem I. Vitamin K1 also serves as a precursor to vitamin K2 and is reported to exhibit anticancer activity in various cell lines.

Chemische Eigenschaften

Phylloquinone is an odorless yellow viscous oil or crystals.

Chemische Eigenschaften

Yellow Oil

Originator

Mephyton ,MSD ,US ,1941

Verwenden

vitamin K1

Verwenden

Labeled Phytonadione, intended for use as an internal standard for the quantification of Phytonadione by GC- or LC-mass spectrometry.

Verwenden

Occurs widely in green plants, algae, photosynthetic bacteria.

Manufacturing Process

11 parts by weight of 2-methyl-1,4-naphthohydroquinone, 30 parts by volume of water-free dioxane and 1.5 parts by volume of boron trifluoride etherate are heated to 50°C. While agitating and introducing nitrogen, 10 parts by weight of phytol dissolved in 10 parts by volume of dioxane are added in the course of 15 minutes. Thereupon, the dark colored reaction mixture is stirred for 20 additional minutes at 50°C, cooled down and 60 parts by volume of ether are added. The reaction mixture is washed first with water, then with a mixture of 3 parts of N-sodium hydroxide and 2 parts of a 2.5% solution of sodium hydrosulfite and again with water. The aqueous extracts are washed with ether. The ether solutions are collected, dried over sodium sulfate and concentrated, toward the end under reduced pressure.
The waxlike condensation product so obtained is mixed with 60 parts by volume of petroleum ether (boiling limits 30°C to 40°C) and agitated with hydrogen in the presence of a little active palladium lead catalyst (Pd-CaCO3catalyst, the activity of which is reduced by the addition of lead and quinoline). During the operation, the condensation product separates in the form of a voluminous white precipitate. The latter is separated by filtration in the absence of air while adding an inert coarse-grained adsorption agent (for example, aluminum silicate salt for filter purposes), and washed with cooled petroleum ether. Thereupon, the 2-methyl-3-phytyl-1,4-naphthohydroquinone is extracted from the filter cake by means of ether, the ethereal solution is concentrated to 100 parts by volume and the reaction product is oxidized by stirring the solution with 6.6 parts by weight of silver oxide during 30 minutes. The solution is filtered through sodium sulfate, the latter is rinsed with ether and the solvent is evaporated. There are obtained 5.7 parts by weight of 2-methyl-3-phytyl-1,4-naphthoquinone (vitamin K1) in the form of a golden yellow oil.

Therapeutic Function

Prothrombogenic vitamin

Allgemeine Beschreibung

Vitamin K1, also known as phylloquinone, consists of naphthalenoid and phytyl groups. Phylloquinone is present abundantly in photosynthetic plants and is a major dietary source. It is a fat-soluble vitamin.

Biochem/physiol Actions

Vitamin K1 (Phylloquinone) is a lipid soluble polycyclic aromatic ketone used as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX and X; anticoagulant factors protein C and S and as a cell signaling factor. Vitamin K1 is essential for blood coagulation, bone and vascular metabolism. Phylloquinone from green leafy vegetables and vegetable oil is the most important dietary source of vitamin K for humans.

mögliche Exposition

Phylloquinone is a dietary component essential for normal biosynthesis of several factors required for clotting of blood; as a therapeutic drug used to correct bleeding tendency; and as a food supplement.

Veterinary Drugs and Treatments

The principal uses of exogenously administered phytonadione is in the treatment of anticoagulant rodenticide toxicity. It is also used for treating dicumarol toxicity associated with sweet clover ingestion in ruminants, sulfaquinoxaline toxicity, and in bleeding disorders associated with faulty formation of vitamin K-dependent coagulation factors.

Versand/Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

läuterung methode

Vitamin K1 is a yellow viscous oil, which can be distilled at high vacuum practically unchanged. It is insoluble in H2O, but soluble in common organic solvents. Store it in the dark under N2 as it is oxygen sensitive. It has  1cm 328 at 248nm. [Fieser et al. J Am Chem Soc 61 2557 1939, Hirschmann et al. J Am Chem Soc 76 4592 1954, Isler & Doebel Helv Chim Acta 27 225 1954, Beilstein 7 IV 2496.]

Inkompatibilitäten

Phylloquinone is photosensitive; decomposes in sunlight and is destroyed by alkali hydroxides and reducing agents such as hydrideds and active metals. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.

Waste disposal

It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quantities shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Phytomenadion Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Phytomenadion Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 448)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58
Hebei Yanxi Chemical Co., Ltd.
+8618633081222
peter@yan-xi.com CHINA 708 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com China 9156 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 567 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58

84-80-0(Phytomenadion)Verwandte Suche:


  • Kativn K1
  • Phytomenadione (Vitamin K1)
  • vitamin K1 micro-capsule
  • PHYLLOQUINONE
  • PHYTOMENADIONE
  • PHYTONADIONE
  • kativn
  • Kephton
  • Kinadion
  • K-Ject
  • Konakion
  • Mephyton
  • Monodion
  • Mono-Kay
  • Phyllochinon
  • Phythyl-menadion
  • Phytylmenadione
  • Synthex P
  • synthexp
  • theta-(e)]]-a-[thet
  • trans-Phylloquinone
  • Vitamin K1 1% powder
  • phylloguinone
  • PHYTONADIONE (PHYLLOQUINONE)
  • VITAMIN K1 (NATURAL) (USP) (PHYTONADIONE)
  • Vitamin K1(>99.5%Cis-K1<1.0%)
  • Vitamin K1(>99.5%Cis-K1<5.0%)
  • 2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, VitaminK1(20), VitaminK1
  • 2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, VitaminK1(20)
  • Vitamin K1 Oll [Phyto (Me) Nadione (Phylloguinone)]
  • hytomenadione
  • hytonadione
  • Vitamin K1 5% powder
  • Vitamin K1(>99.0%Cis-K1≤21.0%)
  • 3-Phytylmenadione 2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
  • VitaminK1,2-Methyl-3-phytyl-1,4-naphthoquinone, 3-Phytylmenadione, Phylloquinone, VitaminK1(20)
  • Vitamin K1 100mg [84-80-0]
  • Phytonadione (500 mg) (Vitamin K1)
  • Vitamin K1-[2H7] (Phytonadione)
  • 2',3'-t
  • 2-Methyl-3-[(2E,7R,11R)-3,7,11,15-tetraMethyl-2-hexadecenyl]-1,4-naphthalenedione
  • 2-Methyl-3-phytyl-1,4-naphthoquinone Phylloquinone
  • ,r*-(e)))-
  • [r-[r*,R*-(E)]]-2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-napthalenedione
  • [r-[r*,R*-(E)]]-2-Methyl-3-(3-7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
  • 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-
  • 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, [R-[R*,R*-(E)]]-
  • 1,4-Naphthoquinone, 2-methyl-3-phytyl-
  • 2',3'-trans-Vitamin K1
  • 2’,3’-trans-vitamink1
  • 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-4-naphthalenedione
  • 2-Methyl-3-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone
  • 2-Methyl-3-phythyl-1,4-naphthochinon
  • 2-Methyl-3-phytyl-1,4-naphthochinon
  • 2-Methyl-3-phytyl-1,4-napthoquinone
  • 2-methyl-3-phytyl-4-naphthoquinone
  • VITAMIN K1
  • VITAMIN K1(20)
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