Lestaurtinib
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- CAS-Nr.
- 111358-88-4
- Englisch Name:
- Lestaurtinib
- Synonyma:
- SP 924;KT 5555;CEP 701;SPM-924;CS-1165;ritatinib; A 154475.0;lestaurtinib;KT-5555 hydrate;CEP-701 hydrate
- CBNumber:
- CB3506750
- Summenformel:
- C26H21N3O4
- Molgewicht:
- 439.47
- MOL-Datei:
- 111358-88-4.mol
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Lestaurtinib Eigenschaften
- Schmelzpunkt:
- 215-220°C
- Siedepunkt:
- 723.0±60.0 °C(Predicted)
- Dichte
- 1.70±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- Löslichkeit
- DMSO: >10mg/mL
- Aggregatzustand
- white powder
- pka
- 13.37±0.40(Predicted)
- Farbe
- White or off-white
- Stabilität:
- Photosensitive
Lestaurtinib Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Lestaurtinib is Off-White Solid
Verwenden
Lestaurtinib is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML)
Biologische Aktivität
Potent JAK2, FLT3 and TrkA inhibitor (IC 50 values are 0.9, 3 and < 25 nM respectively) that prevents STAT5 phosphorylation (IC 50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC 50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo .
Lestaurtinib Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Lestaurtinib Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 118)Lieferanten
111358-88-4()Verwandte Suche:
- lestaurtinib
- (9S-(9α,10β,12α))-2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxyMethyl)-9-Methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
- SPM-924
- CEP-701 hydrate
- KT-5555 hydrate
- Lestaurtinib hydrate
- A 154475.0
- (9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:321kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one
- CEP 701
- KT 5555
- SP 924
- Lestaurtinib
(KT-5555
- CS-1165
- (15S,16S,18R)-16-HYDROXY-16-(HYDROXYMETHYL)-15-METHYL-28-OXA-4,14,19-TRIAZAOCTACYCLO[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]OCTACOSA-1(26),2(6),7(27),8,10,12,20,22,24-NONAEN-3-ONE
- LESTAURTINIB (CEP-701;KT-5555)
- 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)-
- KT5555-Lestaurtinib
- Lestaurtinib USP/EP/BP
- ritatinib
- 111358-88-4
- C26H21N3O4
- Inhibitor
- Intermediates & Fine Chemicals
- Pharmaceuticals
