HUMAN IL-1BETA

HUMAN IL-1BETA Struktur
97599-21-8
CAS-Nr.
97599-21-8
Englisch Name:
HUMAN IL-1BETA
Synonyma:
HUMAN EP;HUMAN MCF;HUMAN LAF;HUMAN LEM;HIL-1BETA;RHIL-1BETA;HUMAN IL-1B;IL-1B, HUMAN;IL-1F2 (HUMAN);HUMAN IL-1BETA
CBNumber:
CB3663589
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

HUMAN IL-1BETA Eigenschaften

storage temp. 
-20°C
Aggregatzustand
lyophilized powder
Farbe
white to off-white

Sicherheit

WGK Germany  3
RTECS-Nr. NM9740000

HUMAN IL-1BETA Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

IL-1β (interleukin 1 β) human has been used to study the effect of pro- and anti-inflammatory mediators on leukotriene B4 and C4 synthesis as well as secretion in an inflamed porcine endometrium. It has been used to study the effect of cytokines on synthesis and secretion of leukotrienes from endometrial epithelial cells of pigs.

Allgemeine Beschreibung

IL-1β (interleukin 1 β) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. It is synthesized as a pro-IL-1β which is changed to active form IL-1β with the help of pro-inflammatory protease caspase-1. IL-1β belongs to the IL-1 gene family. The gene is mapped to human chromosome 2q14. Recombinant human IL-1β is a 17.3kDa protein containing 153 amino acid residues.

Biochem/physiol Actions

Both IL-1α (interleukin 1 α) and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF (fibroblast growth factor)-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. IL-1β is involved in proinflammatory and immunological responses. Some of them include enhancing IL-2 generation, and increasing circulating NO (nitric oxide) and bringing neutrophils. It also regulates gene expression of inflammatory cytokines, mesenchymal growth factors and colony stimulating factors. IL-1β is present in chronic inflamed tissues and also in tissues going for fibrogenesis. It brings neutrophil and macrophage to the site of infection. Mutations in IL-1β gene are linked with renal manifestations and renal sequelae in Henoch-Sch?nlein purpura. It is also associated with destruction of β-cell in type 1 diabetes.

HUMAN IL-1BETA Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


HUMAN IL-1BETA Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 44)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973185 4009686088
3193328036@qq.com China 29797 68
Shanghai Universal Biotech Co.,Ltd 18768175414
gaojun@univ-bio.com China 24998 58

97599-21-8()Verwandte Suche:


  • IL-1F2 (HUMAN)
  • IL-1B, HUMAN
  • IL-1 BETA, HUMAN
  • IL-1BETA IL-1 LYMPHOCYTE ACTIVATING FACTOR HUMAN
  • HUMAN MONONUCLEAR CELL FACTOR
  • HUMAN INTERLEUKIN-1BETA
  • HUMAN IL-1B
  • HUMAN MCF
  • RECOMBINANT HUMAN IL-1B
  • RHIL-1BETA
  • INTERLEUKIN,HUMAN,RECOMBINANT,CELLCULTUREGRADE
  • HUMAN LYMPHOCYTE-ACTIVATING FACTOR
  • HUMAN LEUKOCYTE ENDOGENOUS MEDIATOR
  • HUMAN LAF
  • HUMAN LEM
  • HUMAN ENDOGENOUS PYROGEN
  • HUMAN IL-1BETA
  • HUMAN CATABOLIN
  • HUMAN EP
  • HIL-1BETA
  • INTERLEUKIN-1BETA, HUMAN
  • INTERLEUKIN-1BETA, HUMAN, RECOMBINANT
  • Interleukin-1β, Human, Recombinant, E. coli
  • Interleukin-1beta (IL-1beta),human,recombinant
  • 98% (HPLC), suitable for cell culture
  • 97599-21-8
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