CALPAIN INHIBITOR III
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- CAS-Nr.
- 88191-84-8
- Englisch Name:
- CALPAIN INHIBITOR III
- Synonyma:
- CS-1705;Calp III;MDL 28170;Z-Val-Phe-H;Z-VAL-PHE-CHO;4R)-Tofacitinib;Z-L-Val-L-Phe-OH;Z-VAL-PHE-ALDEHYDE;Cbz-L-Val-L-Phe-OH;CALPAIN INHIBITOR III
- CBNumber:
- CB3723465
- Summenformel:
- C22H26N2O4
- Molgewicht:
- 382.45
- MOL-Datei:
- 88191-84-8.mol
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CALPAIN INHIBITOR III Eigenschaften
- Siedepunkt:
- 595.6±50.0 °C(Predicted)
- Dichte
- 1.153±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Löslichkeit
- DMSO: 26 mg/mL
- Aggregatzustand
- White lyophilized solid
- pka
- 11.05±0.46(Predicted)
- Farbe
- White
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CALPAIN INHIBITOR III Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
MDL 28170 acts as a caplain inhibitor reducing hypoxia in ischemic-retinopathy, and various other neuroprotective effects.
Definition
ChEBI: A dipeptide resulting from the formal condensation of the carboxy group of N-benzyloxycarbonyl-L-valine with the amino group of L-phenylalanine aldehyde. It is a potent cell-permeable inhibitor of calpai
I and II, and is also a gamma-secretase inhibitor.
Allgemeine Beschreibung
A potent, cell-permeable inhibitor of calpain I and II (K
i = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.
Biologische Aktivität
Potent, selective inhibitor of calpain and cathepsin B (K i values are 10 and 25 nM respectively) that does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo .
CALPAIN INHIBITOR III Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CALPAIN INHIBITOR III Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 130)Lieferanten
88191-84-8()Verwandte Suche:
- CALPAIN INHIBITOR III
- CARBOBEZOXY-VALINYL-PHENYLALANINALZ-VAL-PHE-CHO
- CARBOBENZOXY-VALINYL-PHENYLALANINAL
- MDL 28170
- Z-VAL-PHE-ALDEHYDE
- Z-VAL-PHE-CHO
- MDL 28170, Z-Val-Phe-al
- Cbz-L-Val-L-Phe-OH
- Z-L-Val-L-Phe-OH
- N-[N-[(Phenylmethoxy)carbonyl]-L-valyl]-phenylalaninal
- Calp III
- Z-Val-Phe-H
- N-[(1S)-1-[[(1-Formyl-2-phenylethyl)amino]carbonyl]-2-methylpropyl]carbamic acid phenylmethyl ester
- Calpain Inhibitor III - CAS 88191-84-8 - Calbiochem
- CS-1705
- Carbamic acid, N-[(1S)-1-[[(1-formyl-2-phenylethyl)amino]carbonyl]-2-methylpropyl]-, phenylmethyl ester
- Benzyl ((2S)-3-methyl-1-oxo-1-((1-oxo-3-phenylpropan-2-yl)amino)butan-2-yl)carbamate
- 4R)-Tofacitinib
- 88191-84-8
- Apoptosis Inhibitors
- Cell Biology
- Cell Signaling and Neuroscience
- Apoptosis and Cell Cycle
- BioChemical
- inhibitor
