TISSUE PLASMINOGEN ACTIVATOR, HUMAN
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- CAS-Nr.
- 189263-81-8
- Englisch Name:
- TISSUE PLASMINOGEN ACTIVATOR, HUMAN
- Synonyma:
- TISSUE PLASMINOGEN ACTIVATOR;TPA;TPA, HUMAN;1-CHAIN TPA;2-CHAIN TPA;TISSUE PLASMINOGEN ACTIVATOR, HUMAN;TISSUE PLASMINOGEN ACTIVATOR 2-CHAIN;TISSUE PLASMINOGEN ACTIVATOR 1-CHAIN;9,10-Bis[N-(m-tolyl)anilino]anthracene;9,10-Bis[N-(m-tolyl)anilino]anthracene
- CBNumber:
- CB3746518
- Summenformel:
- C40H32N2
- Molgewicht:
- 540.7
- MOL-Datei:
- 189263-81-8.mol
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TISSUE PLASMINOGEN ACTIVATOR, HUMAN Eigenschaften
- Schmelzpunkt:
- 262 °C
- Siedepunkt:
- 723.8±53.0 °C(Predicted)
- Dichte
- 1.194±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -0.33±0.50(Predicted)
- Aggregatzustand
- Lyophilized
- Farbe
- Light yellow to Yellow to Orange
TISSUE PLASMINOGEN ACTIVATOR, HUMAN Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
off-white powder
Verwenden
Tissue plasminogen activator has been used in a study to assess treatment risks of intracranial hemorrhage among patients with acute ischemic stroke. Tissue plasminogen activator has also been used in a study to investigate the successful treatment of early thrombosis of HeartWare left ventricular assist devices with intraventricular thrombolytics. Human tissue plasminogen activator has been used to study the effect of tyrosinase-related protein 2 (TRP-2) expression on melanin production in sheep.
Allgemeine Beschreibung
Recombinant tPA (rtPA), alteplase (Activase), is identicalwith endogenous tPA. rtPA lacks a glycosyl residue atAsn184. At one time, rtPA was produced in two-chain formin CHO cultures. Now, large-scale cultures of recombinanthuman melanoma cells in fermenters are used to produce aproduct that is about 80% single-chain rtPA.
Alteplase is used to improve ventricular function followingan acute myocardial infarction, including reducing the incidenceof congestive heart failure and decreasing mortality.The drug is also used to treat acute ischemic stroke aftercomputed tomography (CT) or other diagnostic imaging hasruled out intracranial hemorrhage. rtPA is also used in casesof acute pulmonary thromboembolism and is being investigatedfor unstable angina pectoris.
Alteplase is supplied as powder for injection, and in reconstitutedform (normal saline or 5% dextrose in water) isintended for IV infusion only. The solution expires in 8 hoursat room temperature and must be prepared just before use.
TISSUE PLASMINOGEN ACTIVATOR, HUMAN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
TISSUE PLASMINOGEN ACTIVATOR, HUMAN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 71)Lieferanten
189263-81-8()Verwandte Suche:
- 2-CHAIN TPA
- 1-CHAIN TPA
- Tissue Plasminogen Activator from human melanoma cells
- 9,10-Bis[N-(m-tolyl)anilino]anthracene
- TISSUE PLASMINOGEN ACTIVATOR, HUMANphenyl)-N,N'-diphenyl-
- TISSUE PLASMINOGEN ACTIVATOR, HUMAN
- TISSUE PLASMINOGEN ACTIVATOR 1-CHAIN
- TISSUE PLASMINOGEN ACTIVATOR 2-CHAIN
- TPA, HUMAN
- TPA
- 9,10-Bis[N-(m-tolyl)anilino]anthracene
- 9-N,10-N-bis(3-methylphenyl)-9-N,10-N-diphenylanthracene-9,10-diamine
- 9,10-Anthracenediamine, N9,N10-bis(3-methylphenyl)-N9,N10-diphenyl-
- N,N'-Bis(3-methylphenyl)-N,N'-diphenyl-9,10-anthracenediamine
- N,N'-Diphenyl-N,N'-di(m-tolyl)-9,10-anthracenediamine
- N9,N10-Diphenyl-N9,N10-di-m-tolylanthracene-9,10-diamine
- TISSUE PLASMINOGEN ACTIVATOR
- 189263-81-8
- Serum Related EnzymesEnzymes, Inhibitors, and Substrates
- Therapeutic EnzymesProteolytic Enzymes and Substrates
- Tissue Plasminogen Activator
- Application Index
- Proteases&Protein Sequencing
- ProteasesApplication Index
- Selective Proteolytic Enzymes
- Serum Proteins and Related Enzymes
