ChemicalBook
Chinese english Germany Japanese Korea

L-Tryptophan Produkt Beschreibung

L-Tryptophan Struktur
73-22-3
CAS-Nr.
73-22-3
Bezeichnung:
L-Tryptophan
Englisch Name:
L-Tryptophan
Synonyma:
TRP;eh121;L-Trp;L-Ttp;EH 121;Lyphan;trofan;Eltrip;Tryptan;L-Trp-OH
CBNumber:
CB3750054
Summenformel:
C11H12N2O2
Molgewicht:
204.23
MOL-Datei:
73-22-3.mol

L-Tryptophan Eigenschaften

Schmelzpunkt:
289-290 °C (dec.)(lit.)
alpha 
-31.1 º (c=1, H20)
Siedepunkt:
342.72°C (rough estimate)
Dichte
1.34
Brechungsindex
-32 ° (C=1, H2O)
storage temp. 
2-8°C
Löslichkeit
20% NH3: 0.1 g/mL at 20 °C, clear, colorless
Aggregatzustand
powder
pka
2.46(at 25℃)
Farbe
White to yellow-white
PH
5.5-7.0 (10g/l, H2O, 20℃)
Optische Aktivität
[α]20/D 31.5±1°, c = 1% in H2O
Wasserlöslichkeit
11.4 g/L (25 ºC)
Merck 
14,9797
BRN 
86197
Stabilität:
Stable. Incompatible with strong acids, strong oxidizing agents.
InChIKey
QIVBCDIJIAJPQS-VIFPVBQESA-N
CAS Datenbank
73-22-3(CAS DataBase Reference)
NIST chemische Informationen
L-Tryptophan(73-22-3)
EPA chemische Informationen
L-Tryptophan (73-22-3)

Sicherheit

Kennzeichnung gefährlicher Xi
R-Sätze: 33-40-62-41-37/38-36/37/38-22
S-Sätze: 24/25-36/37/39-36-26
WGK Germany  2
RTECS-Nr. YN6130000
8
TSCA  Yes
HS Code  29339990
Giftige Stoffe Daten 73-22-3(Hazardous Substances Data)
Toxizität LD508mmol / kg (rat, intraperitoneal injection). It is safe when used in food (FDA, §172.320, 2000).

L-Tryptophan Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R33:Gefahr kumulativer Wirkungen.
R40:Verdacht auf krebserzeugende Wirkung.
R62:Kann möglicherweise die Fortpflanzungsfähigkeit beeinträchtigen.
R41:Gefahr ernster Augenschäden.
R37/38:Reizt die Atmungsorgane und die Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.

S-Sätze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

White to off-white crystalline powder

Chemische Eigenschaften

Appearance: white crystalline powder. Odorless, slightly bitter taste;
Solubility: slightly soluble in water (1.14%, 25 ℃), insoluble in ethanol; soluble in dilute acid or dilute alkali. mp 289 ° C (decomposition).
Isoelectric point: 5.89. [α] D + 2.8 (5 mol / L HCl), [α] D + 6.2 (0.5 mol / L NaOH).
It can be colored upon long-term exposure to light. Its co-heating reaction with water will generate a small amount of indole while heating in the presence of sodium hydroxide and copper sulfate will produce a large amount of indole. It is stable upon heating together with acid in the dark, but is easily to be decomposed when heated together with other amino acids, carbohydrates and aldehydes. L-tryptophan will be completely decomposed when applying acid to break down the protein.

Verwenden

adrenergic agonist

Verwenden

tryptophan is one of the 21 amino acids comprising a protein. Tryptophan is a component of the skin’s natural moisturizing factors.

Definition

ChEBI: The L-enantiomer of tryptophan.

Trademarks

Ardeytropin;Kalma;Optimax;Sedanoct.

Weltgesundheitsorganisation (WHO)

L-tryptophan, an essential aminoacid and precursor of serotonin, was introduced into medicine in 1963 for the treatment of depression and sleep disorders. Its effectiveness in these conditions has, however, never been convincingly demonstrated. It is also widely used in dietary supplements, parenteral nutrition preparations and dietary products for children with phenylketonuria. In 1989, reports from the USA showed an association between the consumption of L-tryptophan containing preparations and the development of eosiniphilia-myalgia syndrome (EMS), a condition characterized by intense eosinophilia, severe muscle and joint pain, swelling of the arms and legs, skin rashes and possible fever. Some of the reported cases have been fatal. Since it is not yet clear whether L-tryptophan itself or an unidentified contaminant is the cause of the EMS, many drug regulatory authorities have suspended the marketing authorization of products containing tryptophan pending further investigation, whereas others have withdrawn these products or restricted their use.

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 3711, 1984 DOI: 10.1021/jo00194a008

Allgemeine Beschreibung

White powder with a flat taste. An essential amino acid; occurs in isomeric forms.

Air & Water Reaktionen

Slightly soluble in water.

Reaktivität anzeigen

Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition L-Tryptophan emits toxic fumes.

Brandgefahr

Flash point data for L-Tryptophan are not available. L-Tryptophan is probably combustible.

Sicherheitsprofil

Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. Human mutation data reported. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of NOx.

läuterung methode

Crystallise L-tryptophan from H2O/EtOH, wash it with anhydrous diethyl ether and dry it at room temperature in a vacuum over P2O5. It sublimes at 220-230o/0.03mm with 99% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Cox & King Org Synth Coll Vol II 612 1943, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2316-2345 1961, Beilstein 22 IV 6765.]

L-Tryptophan Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


L-Tryptophan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 736)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1275 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17505 58
Hengshui Haoye Chemical Co.,Ltd.
0318-2102300
hy@chemcoms.com CHINA 221 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20914 58
Shanghai Bojing Chemical Co.,Ltd.
+86-21-37122233
+86-21-37127788 Candy@bj-chem.com CHINA 497 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55

73-22-3(L-Tryptophan)Verwandte Suche:


  • Trytophan (W) Solution, 100ppm
  • L-Tryptophan, Trp
  • L-Tryptophan Vetec(TM) reagent grade, >=98%
  • VWR SURFACE SAMPLING SPONGE WITH NE
  • L-TRYPTOPHAN (13C11,D8,15N2)
  • L-Tryptophan(pharm grade)
  • L-Trp-OH
  • L-Tryptophan, Animal-Free
  • DL-2-AMINO-3-(3-INDOLYL)PROPIONIC ACID
  • DL-ALPHA-AMINO-3-INDOLEPROPIONIC ACID
  • DL-B-3-INDOLYLALANINE
  • DL-TRYPTOPHANE
  • [+/-]-ALPHA-AMINO-3-INDOLEPROPIONIC ACID
  • (s)-1h-indole-3-alanin
  • (s)-1h-indole-3-propanoicaci
  • (S)-alpha-Amino-1H-indole-3-propanoic acid
  • (s)-alpha-amino-1h-indole-3-propanoicacid
  • ai3-18478
  • Alanine, 3-indol-3-yl-
  • alpha-Aminoindole-3-propionic acid
  • alpha-amino-indole-3-propionicaci
  • alpha-aminoindole-3-propionicacid
  • EH 121
  • eh121
  • Indole-3-propionic acid, alpha-amino-
  • L-alpha-aminoindole-3-propionic acid
  • l-alpha-aminoindole-3-propionicacid
  • L-beta-3-indolylalanine
  • L-Trp
  • L-Tryptofan
  • L-Ttp
  • NCI-C01729
  • L-TRYPTOPHAN BIOTECH 99+%
  • L-TRYPTOPHAN EXTRA PURE USP 99+%
  • L-TRYPTOPHAN 99+%
  • L-TryptophanForBiochemistry-(S-2-Amino-3-(3-Lindoly)PropionicAcid)
  • L-TryptophanForBiochemistry
  • TRYPTOPHAN,USP
  • (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid
  • H-DL-TRP-OH (IN BULK QUANTITY)
  • H-TRP-OH (IN BULK QUANTITY)
  • TRYPTOPHAN, DL-(P)
  • TRYPTOPHAN, DL-(RG)
  • (S)-a-Amino-1H-indole-3-propanoic acid
  • (S)-a-Amino-b-indolepropionic acid
  • (S)-a-Aminoindole-3-propionic acid
  • 1H-Indole-3-alanine, (S)-
  • 1H-Indole-3-propanoic acid, a-amino-, (S)-
  • l-a-Aminoindole-3-propionic acid
  • L-Alanine, 3-(1H-indol-3-yl)-
  • L-Tryptophan (9CI)
  • Lyphan
  • Tryptophan, L- (8CI)
  • NSC 13118
  • Tryptophan (9CI)
  • Tryptophan, DL- (8CI)
  • 3BETA-INDOLYLALANINE
  • (+/-)-2-AMINO-3-(3-INDOLYL)PROPIONIC ACID
Copyright 2019 © ChemicalBook. All rights reserved