Paraflutizid

1580-83-2

CAS-Nr.: 1580-83-2

Bezeichnung:: Paraflutizid

Englisch Name:: paraflutizide

Synonyma:: LD-3612;Paraflutizida;paraflutizide;6-Chloro-3-(p-fluorobenzyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;6-chloro-3-(4-fluorobenzyl)-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide;6-chloro-3-[(4-fluorophenyl)methyl]-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide;2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[(4-fluorophenyl)methyl]-3,4-dihydro-, 1,1-dioxide

CBNumber:: CB3875049

Summenformel:: C14H13ClFN3O4S2

Molgewicht:: 405.85

MOL-Datei:: 1580-83-2.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 8

Paraflutizid Eigenschaften

Schmelzpunkt:: 238-240°

Siedepunkt:: 636.2±65.0 °C(Predicted)

Dichte: 1.571±0.06 g/cm3(Predicted)

pka: 8.66±0.40(Predicted)

Sicherheit

Toxizität	LD50 oral in mouse: > 10gm/kg

Paraflutizid Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Paraflutizide, Shanghai Lansheng

Manufacturing Process

A mixture of 5.0 g (0.0357 g/mol) of ρ-fluorophenylethyl alcohol, 2.0 g (0.007 g/mol) of 5-chloro-2,4-disulphamylaniline, 2.0 g (0.0068 g/mol) of potassium bichromate and 15 ml of concentrated hydrochloric acid (0.176 g/mol) and 25 ml of water is heated under reflux for 1 h. The mixture is allowed to cool, and 15 ml of ether are added to separate the excess of ρ-fluorophenylethyl alcohol. The aqueous layer is decanted and frozen for 2 h and the precipitate is separated, washed with water and dried in vacuum over phosphoric anhydride. There are collected 1.35 g (yield 47.5%) of the 1,1-dioxide of 3-ρfluorophenyl-methyl-7-sulphamyl-6-chloro-3,4-dihydrobenzo-1,2,4-thiadiazine, which when recrystallised from 30 ml of 50% alcohol on "Norit" active carbon takes the form of a white crystalline substance, melting point is 239°C.

Therapeutic Function

Diuretic

Paraflutizid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Hydrogenchlorid Kaliumdichromat 5-Chlor-2-methyl-2H-isothiazol-3-on

Downstream Produkte

Paraflutizid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 8)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd	15229059051	1027@dideu.com	China	9925	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24131	58

1580-83-2(Paraflutizid)Verwandte Suche:

Hydrochlorothiazid Chlorothiazid 4-Amino-6-chlorbenzol-1,3-disulfonamid Ethiazid Paraflutizid

paraflutizide
6-Chloro-3-(p-fluorobenzyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
LD-3612
6-chloro-3-(4-fluorobenzyl)-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
6-chloro-3-[(4-fluorophenyl)methyl]-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[(4-fluorophenyl)methyl]-3,4-dihydro-, 1,1-dioxide
Paraflutizida
1580-83-2
C14H13ClFN3O4S2