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Prednisolon Produkt Beschreibung

Prednisolone Struktur
50-24-8
CAS-Nr.
50-24-8
Bezeichnung:
Prednisolon
Englisch Name:
Prednisolone
Synonyma:
deltaf;solone;steran;prednis;ulacort;dicortol;eazolind;hydeltra;predonin;STEROLONE
CBNumber:
CB4109000
Summenformel:
C21H28O5
Molgewicht:
360.44
MOL-Datei:
50-24-8.mol

Prednisolon Eigenschaften

Schmelzpunkt:
240 °C (dec.)(lit.)
alpha 
D25 +102° (dioxane)
Siedepunkt:
412.46°C (rough estimate)
Dichte
1.0963 (rough estimate)
Brechungsindex
100 ° (C=1, Dioxane)
Flammpunkt:
2℃
storage temp. 
-20°C Freezer
Löslichkeit
Very slightly soluble in water, soluble in ethanol (96 per cent) and in methanol, sparingly soluble in acetone, slightly soluble in methylene chloride. It shows polymorphism (5.9).
Aggregatzustand
powder
Wasserlöslichkeit
2.225g/L(25 ºC)
Merck 
14,7721
BRN 
1354103
InChIKey
OIGNJSKKLXVSLS-VWUMJDOOSA-N
CAS Datenbank
50-24-8(CAS DataBase Reference)
EPA chemische Informationen
Prednisolone (50-24-8)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher
R-Sätze:
S-Sätze:
Giftige Stoffe Daten 50-24-8(Hazardous Substances Data)
Toxizität LD50 oral in mouse: 1680mg/kg
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H225 Flüssigkeit und Dampf leicht entzündbar. Entzündbare Flüssigkeiten Kategorie 2 Achtung P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung P264, P280, P305+P351+P338,P337+P313P
H360 Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Fertility (Fruchtbarkeit) Kategorie 1 Achtung
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P210 Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P370+P378 Bei Brand: zum Löschen verwenden.
P403+P235 An einem gut belüfteten Ort aufbewahren. Kühl halten.

Prednisolon Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R34:Verursacht Verätzungen.
R11:Leichtentzündlich.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S16:Von Zündquellen fernhalten - Nicht rauchen.

Chemische Eigenschaften

Crystalline Solid

Originator

Sterane, Pfizer ,US ,1955

Verwenden

Synthetic corticosteroid; metabolically interconvertible with prednisone

Verwenden

glucocorticoid

Verwenden

substance P antagonists (SPA). It mediates its effect by acting on neurokinin 1 receptor

Definition

ChEBI: A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.

Manufacturing Process

The following procedure is described in US Patent 2,837,464: from a solution of 3 grams of yeast extract (Difco) in 3.0 liters of tap water containing 13.2 grams of potassium dihydrogen phosphate and 26.4 grams disodium hydrogen phosphate (pH of the solution, 6.9) 27 portions of 100 ml each are withdrawn, placed in 300 ml Erlenmeyer flasks and sterilized by autoclaving for 15 minutes at 15 pounds steam pressure (120°C). After autoclaving and cooling of the broth, one ml of suspension of Corynebacterium simplex (ATCC 6946) is placed in each flask. The flasks are then shaken on a shake table at 220 rpm and 28°C for 24 hours.
Into each of 27 Erlenmeyer flasks are placed 150 mg of Kendall's Compound F (hydrocortisone). The flasks and contents are then sterilized for 15 minutes at 15 pounds steam pressure (120°C). To each flask are then added 5.0 ml of ethanol. The 24-hour bacterial culture is then transferred aseptically and the resulting suspensions are shaken on a shake table at 220 rpm and 28°C for 48 hours. The pH at the end of the shake period is 7.0.
The contents of all the flasks are combined and extracted with a total of 9.0 liters of chloroform in 3 equal portions. The combined extracts are then concentrated to a residue which weighs 3.75 grams. The MP of the residue is 227°-232°C. From 2.75 grams of this crude material on sludging with 50 ml of acetone and cooling, there is recovered on filtration 1.35 grams of ?1,4pregnadiene-11β,17α,21-triol-3,20-dione,MP 237°-239°C (dec.). Additional product can be recovered from the mother liquor. Recrystallization from acetone raised the MP to 239°-241°C (dec.).

Trademarks

Cortalone(Halsey); Delta-Cortef (Pharmacia & Upjohn); Fernisolone(Ferndale); Meti-Derm (Schering); Prelone (Muro); Prelone(Teva); Sterane (Pfizer).

Therapeutic Function

Glucocorticoid

Allgemeine Beschreibung

Prednisolone,Δ1-hydrocortisone,11β,17,21-trihydroxypregna-1,4-diene-3,20-dione, hasless salt-retention activity than hydrocortisone, but some patients have more frequently experiencedcomplications such as gastric irritation and peptic ulcers.Because of low MC activity, it cannot be used alone for adrenalinsufficiency. Prednisolone is available in varioussalts and esters to maximize its therapeutic utility:
Prednisolone acetate, USP (21-acetate)
Prednisolone sodium phosphate, USP (21-sodiumphosphate)
Prednisolone sodium succinate, USP (21-sodiumsuccinate)
Prednisolone tebutate, USP (21-tebutate).

Hazard

Causes sodium retention; may have side effects similar to cortisone.

Mechanism of action

Prednisolone is hydrocortisone to which has been added a ?1 double bond. This places two double bonds in ring A, which flattens it and increases glucocorticoid action at the expense of mineralocorticoid activity. Prednisolone has fourfold the glucocorticoid activity of hydrocortisone while having approximately half its mineralocorticoid activity. In addition, prednisolone has an increased duration of action compared to hydrocortisone, because the extra double bond in ring A retards its metabolic reduction.

Clinical Use

Prednisolone can be used to treat severe asthmatic attacks that do not respond to conventional treatment, and it is available as the free alcohol for oral administration. The C-21 sodium phosphate (Hydeltrasol) ester is available for parenteral use.

Nebenwirkungen

A prodrug of prednisolone is prednisone. It is the 11-keto analogue of prednisolone and must be converted in vivo to the active 11β-hydroxy compound, which is necessary to hydrogen bond to Asn-564 in the glucocorticoid receptor. Prednisone should not be used in patients with hepatic dysfunction, because their ability to reduce the 11-keto group with 11β-hydroxysteroid dehydrogenase to the active metabolite may be impaired.

Sicherheitsprofil

A poison by intravenous and subcutaneous routes. Moderately toxic by ingestion and intraperitoneal routes. Human teratogenic effects by an unspecified route: developmental abnormalities of the central nervous system; effects on embryo or fetus: fetal death, extra embryonic structures. Human reproductive effects by an unspecified route: stdlbirth. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Veterinary Drugs and Treatments

Glucocorticoids have been used in an attempt to treat practically every malady that afflicts man or animal, but there are three broad uses and dosage ranges for use of these agents. 1) Replacement of glucocorticoid activity in patients with adrenal insufficiency, 2) as an antiinflammatory agent, and 3) as an immunosuppressive. Among some of the uses for glucocorticoids include treatment of: endocrine conditions (e.g., adrenal insufficiency), rheumatic diseases (e.g., rheumatoid arthritis), collagen diseases (e.g., systemic lupus), allergic states, respiratory diseases (e.g., asthma), dermatologic diseases (e.g., pemphigus, allergic dermatoses), hematologic disorders (e.g., thrombocytopenias, autoimmune hemolytic anemias), neoplasias, nervous system disorders (increased CSF pressure), GI diseases (e.g., ulcerative colitis exacerbations), and renal diseases (e.g., nephrotic syndrome). Some glucocorticoids are used topically in the eye and skin for various conditions or are injected intra-articularly or intra-lesionally. The above listing is certainly not complete.
In general, in using glucocorticoids, the following principles should be followed:
1. Glucocorticoids can mask disease! Try not to use them until you have a diagnosis.
2. Make a specific diagnosis!
3. Determine course from outset.
4. Determine endpoint before you starting treating.
5. Use the least potent form for the minimal time.
6. Know where glucocorticoids inappropriate. (Behrend 2007)

Prednisolon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Prednisolon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 355)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
PI & PI BIOTECH INC.
18371201331
020-81716319 Sales@pipitech.com CHINA 3048 55
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales04@yibaibiotech.com CHINA 420 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 19929 60
Beijing Cooperate Pharmaceutical Co.,Ltd
010-60279497
010-60279497 sales01@cooperate-pharm.com CHINA 1817 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22624 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
02783214688 bruce@xrdchem.cn CHINA 568 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 2754 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30039 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8406 58

50-24-8(Prednisolon)Verwandte Suche:


  • Budesonide iMpurit 8
  • Prednisolone/Prednisolone phosphate sodium
  • DEHYDROHYDROCORTISONE
  • HYDRODELTALONE
  • METACORT AND RALONE
  • METACORTANDROLONE
  • 11B,17,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
  • 11BETA,17ALPHA,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
  • 11BETA 17,21-TRIHYDROXYPREGNA-1,4-DIENE-3,20-DIONE
  • 11-BETA,17-ALPHA,21-HYDROXY-1,4-PREGNADIENE-3,20-DIONE
  • 11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE
  • 1-DEHYDROCORTISOL
  • 1-DEHYDROHYDROCORTISONE
  • 1,4-PREGNADIEN-11-B,17,21-TRIOL-3,20-DIONE
  • 1,4-PREGNADIEN-11BETA,17ALPHA,21-TRIOL-3,20-DIONE
  • 1,4-PREGNADIEN-11-BETA, 17,21-TRIOL-3,20-DIONE
  • 1,4-PREGNADIENE-11B,17A,21-TRIOL-3,20-DIONE
  • 1,4-PREGNADIENE-11BETA,17ALPHA,21-TRIOL-3,20-DIONE
  • (8S,9S,10R,11S,13S,14S,17R)-11,17-DIHYDROXY-17-(2-HYDROXY-ACETYL)-10,13-DIMETHYL-6,7,8,9,10,11,12,13,14,15,16,17-DODECAHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE
  • Δ1-Cortisol
  • (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • (8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11,17-dihydroxy-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
  • Prednisolone And Salts
  • Prednisolone Base & derivatives
  • Prednisolone,1,4-Pregnadiene-11β,17α,21-triol-3,20-dione, 1-Dehydrocortisol, 1-Dehydrohydrocortisone, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione
  • Prednisolone (200 mg)
  • Prednisolone (200 mg)N0D2121.000mg/mg(dr)
  • Prednisolon
  • SCHERISOLON
  • STEROLONE
  • PREDNISOLONE
  • PRENOLONE
  • (11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione
  • 1,2-dehydrohydrocortisone
  • 1,4-pregnadiene-3,20-dione-11-beta,17-alpha,21-triol
  • 1,4-pregnadiene-3,20-dione-11beta,17alpha,21-triol
  • 11,17,21-trihydroxy-4-diene-(11beta)-pregna-20-dione
  • 11,17,21-Trihydroxypregna-1,4-diene-3,20-dione
  • Prednisolone COS
  • 1,4-Pregnadien-11,17a,21-triol-3,20-dione-d6
  • Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-, (11β)-
  • Prednisolone Solution
  • Prednisolone Solution, 100ppm
  • 11 BETA, 17 ALPHA 21-TRIHYDROXY- 1, 4 PREGNADIENA 3,20-DIONE
  • (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-diMethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • Prednisolone B.P
  • 20-dione,11-beta,17,21-trihydroxy-pregna-4-diene-3
  • 20-dione,11beta,17,21-trihydroxy-pregna-4-diene-3
  • 3,20-dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene
  • 4-diene-3,20-dione,11,17,21-trihydroxy-,(11.beta.)-Pregna-1
  • codelcortone
  • co-hydeltra
  • cortalone
  • decaprednil
  • decortinh
  • delcortol
  • delta(1)-cortisol
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