BONGKREKIC ACID

11076-19-0

CAS-Nr.: 11076-19-0

Englisch Name:: BONGKREKIC ACID

Synonyma:: edioicacid;bongkrekicaci;BONGKREKIC ACID;bongkrekic acid solution;Bongkrekic Acid (AS SOLUTION);(r-(r*,s*(e,z,z,e,e,z,e)))--trimethyl;Bongkrekic Acid Solution (1.0mg/mL in 0.01 M Tris buffer, pH 7.5);3-carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,14,18,20-heptaen;2,4,8,10,14,18,20-docosaheptaenedioicacid,20-(carboxymethyl)-6-methoxy-2,5,17;(2E,4Z,6R,8Z,10E,14E,17S,18Z,20E)-20-Carboxymethyl-6-methoxy-2,5,17-trimethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid

CBNumber:: CB4140241

Summenformel:: C28H38O7

Molgewicht:: 486.6

MOL-Datei:: 11076-19-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 46

BONGKREKIC ACID Eigenschaften

Schmelzpunkt:: 50-60°

alpha: D25 +162.5°

Siedepunkt:: 715.1±60.0 °C(Predicted)

Dichte: 1.114±0.06 g/cm3(Predicted)

storage temp.: -20°C

Löslichkeit: Soluble in DMSO (up to 100 mg/ml) or in Water (up to 1 mg/ml).

Aggregatzustand: Lyophilized solid

pka: 4.15±0.10(Predicted)

Stabilität:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.

Sicherheit

WGK Germany	-
Giftige Stoffe Daten	11076-19-0(Hazardous Substances Data)
Toxizität	LD50 i.v. in mice: 1.41 mg/kg (Lijmbach)

BONGKREKIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Bongkrekic acid solution has been used as an adenine nucleotide translocator (ANT) inhibitor to find out a different approach for the inhibition of oxidative phosphorylation in intact T98G cells. It has also been used as an inhibitor of the permeabilization transition pore complex (PTPC) pore and a tool to explore the role of PTPC in induction of apoptosis.

Definition

ChEBI: A tricarboxylic acid that is docosa-2,4,8,10,14,18,20-heptaenedioic acid substituted at positions 2 ,5 and 17 by methyl groups, at positions 6 by a methoxy group and at position 20 by a carboxymethyl group.

Enzyminhibitor

This toxic tricarboxylic acid (FWfree-acid = 486.61 g/mol; CAS 11076-19-0), produced Pseudomonas cocovenenans, is a potent competitive inhibitor of the mitochondrial ATP-ADP translocator, effectively blocking nucleotide binding to the carrier. The name is derived from bongkrek, a moldy coconut product produced in Indonesia. The toxin accumulates when P. cocovenenans outgrows the mold. Klingenberg et al. investigated bongkrekate binding to mitochondrial membrane to examine the reorienting site mechanism. The inferred mode of inhibition requires bongkrekate to bind to the single carrier site only from the inner face of the mitochondrial membrane (i.e., the matrix side)). They confirmed the pH-dependent accumulation of [3H]bongkrekate inside the mitochondria which superimposes onto the binding at carrier sites. By breaking the membrane with Lubrol or sonication, binding to the carrier sites could be titrated, and a Kd value of approximately 5 x 10–8 M was determined. The presence of ADP or ATP increases the amount of binding but does not alter the Kd. [35S]Atractylate is displaced by [3H]bongkrekate at a 1:1 molar ratio; this displacement is dependent on ADP concentration with the Km = 0.5 x 10–6 M. See also Atractyloside The isomer known as isobongkrekic acid, which has a cis-double bond at the dicarboxylic acid end of the molecule, has similar biological activity. Target(s): Adenine nucleotide translocator, ADP/ATP carrier; ATPase; bromelain, stem; papain; ficain, or ficin.

BONGKREKIC ACID Upstream-Materialien And Downstream Produkte

Upstream-Materialien

(6R,17S,2E,4Z,8Z,10E,14E,18E,20E)-20-(Carboxymethyl)-6-methoxy-2,5,17-trimethyl-2,4,8,10,14,18,20-docosaheptenedioic acid

Downstream Produkte

BONGKREKIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 46)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
BOC Sciences	+16314854226	inquiry@bocsci.com	United States	19743	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Sinopharm Chemical Reagent Co,Ltd.	86-21-63210123	sj_scrc@sinopharm.com	China	9823	79
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
ChemStrong Scientific Co.,Ltd	0755-66853366 13670046396	sales@chem-strong.com	China	17982	56
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Alta Scientific Co., Ltd.	022-6537-8550 15522853686	sales@altasci.com.cn	China	4515	55
Qingdao IniKem BioPharmaTech Co.,Ltd	18561687109	sales@inikem.com	China	287	55
Shenzhen Regent Biochemical Technology Co., Ltd.	0755-0755-85201366 18938635012	sales@regentsciences.com	China	9287	58

11076-19-0()Verwandte Suche:

Nonactin 4-(4-Hydroxy-3-methoxyphenyl)-3-buten-2-on N-(2-(5-Methoxyindol-3-yl)ethyl)acetamid ((3-Chlorphenyl)hydrazono)-malanonitril ((4-Trifluormethoxy)phenyl)-hydrazono)malononitril Strke Aconitan-3,8,13,14,15-pentol, 1,6,16-Trimethoxy-4-(methoxymethyl)-20-methyl-, 8-Acetat-14-benzoat, (1α,3α,6α,14α,15α,16β)-

bongkrekic acid solution
(2E,4Z,6R,8Z,10E,14E,17S,18Z,20E)-20-Carboxymethyl-6-methoxy-2,5,17-trimethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid
BONGKREKIC ACID
(r-(r*,s*(e,z,z,e,e,z,e)))--trimethyl
2,4,8,10,14,18,20-docosaheptaenedioicacid,20-(carboxymethyl)-6-methoxy-2,5,17
3-carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,14,18,20-heptaen
edioicacid
bongkrekicaci
2,4,8,10,14,18,20-Docosaheptaenedioic acid, 20-(carboxymethyl)-6-methoxy-2,5,17-trimethyl-, (2E,4Z,6R,8Z,10E,14E,17S,18E,20Z)-
Bongkrekic Acid Solution (1.0mg/mL in 0.01 M Tris buffer, pH 7.5)
Bongkrekic Acid (AS SOLUTION)
11076-19-0
C28H38O7
BioChemical
Apoptosis and Cell Cycle
Cell Biology
Apoptosis Inhibitors
Cell Signaling and Neuroscience