AC-YVAD-CHO

AC-YVAD-CHO Struktur
143313-51-3
CAS-Nr.
143313-51-3
Englisch Name:
AC-YVAD-CHO
Synonyma:
YVAD-CHO;L-709049;AC-YVAD-CHO;ICE INHIBITOR;ICE INHIBITOR I;AC-YVAD-ALDEHYDE;TYR-VAL-ALA-ASP-CHO;CASPASE INHIBITOR I;BIOTINYL-AC-YVAD-CHO;ACETYL-YVAD-ALDEHYDE
CBNumber:
CB4158149
Summenformel:
C23H32N4O8
Molgewicht:
492.52
MOL-Datei:
143313-51-3.mol

AC-YVAD-CHO Eigenschaften

Siedepunkt:
937.7±65.0 °C(Predicted)
Dichte
1.276±0.06 g/cm3(Predicted)
storage temp. 
−20°C
Löslichkeit
DMF:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);60.91(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);10.15(Max Conc. mM)
Aggregatzustand
Powder
pka
4.20±0.10(Predicted)
Sensitive 
Moisture Sensitive

Sicherheit

WGK Germany  3

AC-YVAD-CHO Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Ac-YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE; Ki = 0.76 nM) and an acetylated form of the caspase-1 inhibitor YVAD-CHO . It is selective for caspase-1 over caspase-4, -5, -8, -9, and -10 (Kis = 163-970 nM), as well as over caspase-2, -3, -6, and -7 (Kis = >10,000 nM for all). It inhibits activation of caspase-1 and IL-1β in a cell-free assay using LPS-treated THP-1 cell homogenates when used at a concentration of 5 μM. Ac-YVAD-CHO (12.5 μmol/kg) reduces pancreatic levels of IL-18 and serum levels of IL-1β, as well as reduces pyroptosis of pancreatic cells, in a mouse model of cerulein-induced acute pancreatitis but does not decrease pancreatic expression of NOD-like receptor protein 3 (NLRP3). It increases susceptibility to lethal E. coli infection but prevents LPS-induced death in C3H/HeN mice when administered at doses of 5 and 10 mg/kg, respectively.

Verwenden

A potent, specific, and reversible inhibitor of caspases-1, -4 and -5

AC-YVAD-CHO Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


AC-YVAD-CHO Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 90)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Career Henan Chemica Co
+86-0371-86658258 15093356674;
laboratory@coreychem.com China 30255 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29474 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439
sales@nextpeptide.com China 19915 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49739 58
Nanjing TGpeptide
+86-13347807150 +86-13347807150
support@tgpeptide.com China 3279 58
Zhejiang Hangyu API Co., Ltd
+8617531972939
anna@api-made.com China 2944 58
Aladdin Scientific
+1-833-552-7181
sales@aladdinsci.com United States 52927 58
DONBOO AMINO ACID COMPANY
+8613063595538
donboo@donboo.com China 9365 58

  • N-ACETYL-L-TYROSYL-L-VALYL-N-[(1S)-2-CARBOXYL-1-FORMYLETHYL]-L-ALANINAMIDE
  • N-ACETYL-TYR-VAL-ALA-ASP-CHO (ALDEHYDE)
  • N-ACETYL-TYR-VAL-ALA-GLU-AL
  • N-AC-TYR-VAL-ALA-ASP-CHO
  • N-ACETYL-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-TYR-VAL-ALA-ASP-CHO (ALDEHYDE)
  • TYR-VAL-ALA-ASP-CHO
  • YVAD-CHO
  • ICE INHIBITOR
  • ICE INHIBITOR I
  • IL-1BETA CONVERTING ENZYME (ICE) INHIBITOR I
  • IL-1BETA CONVERTING ENZYME INHIBITOR I
  • IL-1BETA CONVERTING ENZYME INHIBITOR
  • L-709049
  • CASPASE INHIBITOR I
  • CASPASE 1 (ICE) INHIBITOR I
  • CASPASE-1 INHIBITOR (ALDEHYDE)
  • CASPASE-1 INHIBITOR I
  • CELL-PERMEABLE YVAD-CHO
  • BIOTINYL-AC-YVAD-CHO
  • BIOTINYL-AC-TYR-VAL-ALA-ASP-CHO
  • ACETYL-TYR-VAL-ALA-ASP-ALDEHYDE
  • ACETYL-YVAD-ALDEHYDE
  • ACETYL-L-TYROSYL-L-VALYL-L-ALANYL-L-ASPART-1-AL
  • AC-TYR-VAL-ALA-ASP-H (ALDEHYDE)
  • AC-YVAD-ALDEHYDE
  • AC-YVAD-CHO
  • AC-TYR-VAL-ALA-ASP-ALDEHYDE
  • AC-TYR-VAL-ALA-ASP-ALDEHYDE (PSEUDO ACID)
  • AC-TYR-VAL-ALA-ASP-CHO
  • ACETYL-YVAD ALDEHYDE L-709,049, SYNTHETI C
  • ICE (CASPASE I) INHIBITOR I
  • Caspase 1 (ICE) Inhibitor 2
  • N-acetyl-Tyr-Val-Ala-aspartinal
  • Acetyl-tyrosyl-valyl-alanyl-aspartal
  • N-Acetyl-Tyr-Val-Ala-Asp-al
  • (S)-N-Acetyl-L-tyrosyl-L-valyl-N-(2-carboxy-1-formylethyl)-L-alaninamide
  • Acetyl-tyrosyl-valyl-alanyl-aspartinal
  • Acetyl-Tyr-Val-Ala-Asp-cho
  • Ac-YVAD-CHO, L-709049
  • L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-
  • AC-YVAD-CHO USP/EP/BP
  • Ac-YVAD-CHO (N-Ac-Tyr-Val-Ala-Asp-CHO)
  • N-Ac-Tyr-Val-Ala-Asp-Aldehyde
  • 143313-51-3
  • C23H32N4O8
  • Biochemicals and Reagents
  • BioChemical
  • Amino Acids and Peptides
  • Other Peptides
  • Peptides
  • Caspases/Apoptosis
  • peptide
  • Pepetides
  • peptides
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