Metoprolol

Metoprolol Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Metoprolol is a β-adrenergic blocking antihypertensive and antianginal agent; to treat raised blood pressure; to prevent attacks of angina (pain from an inadequate oxygen supply to the heart); after a heart attack to prevent further damage to the heart muscle; treatment of some disturbances of heart rhythm; used to help prevent attacks of migraine; in ophthalmic preparations; treatment of myocardial infarcts.

Mechanism of action

Unlike propranolol, which blocks both β1 and β2-adrenoreceptors, metroprolol exhibits cardioselective action, i.e. in therapeutic doses, it blocks β1-adrenoreceptors with insignificant effects on β2-adrenoreceptors.

Stoffwechsel

The pharmacokinetic profile of metoprolol (Lopressor) is similar to that of propranolol. Metoprolol is readily and rapidly absorbed after oral administration and is subject to a significant amount of first-pass metabolism by the liver. Curiously, the duration of metoprolol’s action is longer than one would predict from its plasma half-life, which ranges from 0.5 to 2.5 hours. The degree of binding of metoprolol to plasma proteins is modest (10%). The extensive distribution of metoprolol to the lungs and kidney is typical of a moderately lipophilic drug. Metoprolol undergoes considerable metabolism;only 3 to 10% of an administered dose is recovered as unchanged drug.The metabolites are essentially inactive as -receptor blocking agents and are eliminated primarily by renal excretion. Small amounts of the drug are present in the feces.

Metoprolol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Metoprolol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Wuhan Quanjinci New Material Co.,Ltd.	+8615271838296	kyra@quanjinci.com	China	1532	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Hebei Lingding Biotechnology Co., Ltd.	+86-18031140164 +86-19933155420	erin@hbldbiotech.com	China	878	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	992	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58
Shandong Zhishang New Material Co., Ltd.	+8617653113209	sales002@sdzschem.com	China	3050	58
Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd.	+86-029-86185165 +8618629664246	guoyuan@eastchinapharm.com	China	1615	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9116	58

37350-58-6(Metoprolol)Verwandte Suche:

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• 1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol
• 1-(Isopropylamino)-3-[p-(2-methoxyethyl)phenoxy]-2-propanol
• 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-
• 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (±
• 2-Propanol, 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-, (.+/-.)-
• CGP 2175
• H-23/96
• Lopresoretic
• Metoprolol (base and/or unspecified salts)
• 1-[4-(2-methoxyethyl)phenoxy]-3-propan-2-ylamino-propan-2-ol
• (±)-Metoprorol
• Methoprorol
• Metoprorol
• Metoprolol (free base)
• Metoprolol
• Metoprolol API (free base)
• cgp2175
• Metroprolol
• Metoprolol Base
• metoprol
• Metoprolol Impurity K
• 1-(Isopropylamino)-3-(4-(2-methoxyethyl)phenoxy) propan-2-ol or Metoprolol Base
• 37350-58-6
• C15H25NO3
• Cardiovascular