Noscapinhydrochlorid
|
|
|
- CAS-Nr.
- 912-60-7
- Bezeichnung:
- Noscapinhydrochlorid
- Englisch Name:
- NOSCAPINE HYDROCHLORIDE
- Synonyma:
- capvalhydrochloride;NOSCAPINEHCL;opianhydrochloride;noscapiniumchlorid;lyobexhydrochloride;nsc5366hydrochloride;vadebexhydrochloride;NOSCAPINE BASE / HCL;Noscapinhydrochlorid;coscopinhydrochloride
- CBNumber:
- CB4168056
- Summenformel:
- C22H24ClNO7
- Molgewicht:
- 449.88
- MOL-Datei:
- 912-60-7.mol
|
Noscapinhydrochlorid Eigenschaften
- Schmelzpunkt:
- 221-223 °C(lit.)
- storage temp.
- 2-8°C
- Löslichkeit
- Freely soluble in water and in ethanol (96 per cent). Aqueous solutions are slightly acid; the base may be precipitated when the solutions are allowed to stand.
- Farbe
- Crystals
- Merck
- 13,6752
- EPA chemische Informationen
- 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (912-60-7)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn,Xi |
|
|
| R-Sätze: |
22 |
|
|
| S-Sätze: |
36 |
|
|
| RIDADR |
1544 |
|
|
| WGK Germany |
3 |
|
|
| RTECS-Nr. |
NP7225000 |
|
|
| F |
10 |
|
|
| HS Code |
2939.19.5000 |
|
|
| HazardClass |
6.1(b) |
|
|
| PackingGroup |
III |
|
|
| Toxizität |
cyt-ham:fbr 60 mg/L ESKHA5 96,55,78 |
|
|
| Bildanzeige (GHS) |
|
| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H336 |
Kann Schläfrigkeit und Benommenheit verursachen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Schläfrigkeit und Benommenheit) |
Warnung |
|
P261, P271, P304+P340, P312,P403+P233, P405, P501 |
|
| Sicherheit |
|
Noscapinhydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White or almost white, crystalline powder or colourless crystals, hygroscopic.
Verwenden
Noscapine Hydrochloride is a bradykinin B and tubulin inhibitor. Anti-viral.
Biologische Aktivität
Opioid alkaloid with several actions. Binds to tubulin, arresting cells in mitosis and inducing apoptosis. Also is an antagonist at bradykinin receptors (pA 2 = 6.68), inhibits carbachol-stimulated phosphoinositol turnover and enhances forskolin-stimulated increases in cAMP levels in CNS tissues. Clinically used antitussive agent.
Sicherheitsprofil
Poison by intravenous route.Moderately toxic by ingestion and subcutaneous routes.Mutation data reported. When heated to decomposition itemits very toxic fumes of HCl and NOx.
Noscapinhydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Noscapinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 149)Lieferanten
912-60-7(Noscapinhydrochlorid)Verwandte Suche:
5-(2-Aminoethyl)pyrogallolhydrochlorid
6,7-Dimethoxy-3-(5,6,7,8-tetra-hydro-6-methyl-1,3-dioxolo(4,5-g)-isochinolin-5-yl)-1(3H)isobenzo-furanon-hydrochlorid, (S(R*,S*))-
(S)-1,2,3,4-Tetrahydro-1-[(3-hydroxy-4-methoxyphenyl)methyl]-6-methoxy-2-methylisochinolin-7-ol
4-Pyrrolidin-1-ylbutyronitril
[1,3(Oder 1,4)-phenylenbis(1-methylethyliden)]bis[tert-butyl]peroxid
(R*,S*)-(±)-α-(1-Aminoethyl)-4-hydroxybenzylalkoholhydrochlorid
Noscapinhydrochlorid
Salicylsäure-ethylester
Dioxifedrin
3-Methoxysalicylsure
Butyrophenon
1-(Methylthio)butan-2-on
1-(4,4-Bis(4-fluorphenyl)butyl)-4-(4-chlor-3-(tri-fluormethyl)phe-nyl)-4-piperidinol
Febuprol
But-1-in
Buta-1,3-dienylmethylether
But-2-in-1,4-diol
(±)-α-[(Ethylamino)methyl]-m-hydroxybenzylalkohol
- NOSCAPINE HYDROCHLORIDE
- NARCOTINE HYDROCHLORIDE
- ,3-dioxolo(4,5-g)isoquinolin-5-yl)-,hydrochloride,(s-(r*,s*))-
- 1(3h)isobenzofuranone,6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1
- 1-alpha-narcotinehydrochloride
- coscopinhydrochloride
- coscotabshydrochloride
- key-tusscapinehydrochloride
- longatinhydrochloride
- lyobexhydrochloride
- methoxyhydrastinehydrochloride
- narcomprenhydrochloride
- narcosinehydrochloride
- nectadonhydrochloride
- nsc5366hydrochloride
- opianhydrochloride
- opianinehydrochloride
- terbenolhydrochloride
- tusscapinehydrochloride
- vadebexhydrochloride
- NOSCAPINE EP STANDARD
- NOSCAPINE USP STANDARD
- NOSCAPINEHCL
- (3S)-6,7-DIMETHOXY-3-[(5R)-5,6,7,8-TETRAHYDRO-4-METHOXY-6-METHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLIN-5-YL]-1(3H)-ISOBENZOFURANONE HYDROCHLORIDE
- 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-(5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)-, hydrochloride, [S-(R*,S*)]-
- 1(3H)-Isobenzofuranone, 6,7-dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-, hydrochloride, (3S)- (9CI)
- l-Narcotine hydrochloride
- Narcotine, hydrochloride (7CI, 8CI)
- NOSCAPINE BASE / HCL
- Noscapine hydrate hydrochloride
- 6,7-Dimethoxy-3-(4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-5-yl)-3H-2-benzofuran-1-one hydrochloride
- (3S)-6,7-Dimethoxy-3-[(5R)-5,6,7,8-tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl]-1(3H)-isobenzofuranonehydrochloride
- Noscapine hydrochloride hydrate,Narcotine hydrochloride
- Narcotine HCl((S,R)-Noscapine)
- Noscapine HCl(Nectodon)
- NoscapineHydrochlorideMonohydrate>
- NOSCAPINE HYDROCHLORIDE USP/EP/BP
- Noscapinhydrochlorid
- capvalhydrochloride
- Papaverine hydrochloride impurity A （NACOTINE HYDROCHLORIDE）
- noscapiniumchlorid
- 912-60-7
- C22H23NO7ClH
- C22H23NO7HCl
- C22H23NO7HClxH2O
- C23H23NO7HCl
- Analytical Standards
- Analytical Chromatography Product Catalog
- Alphabetic
- Chiral Building Blocks
- Asymmetric Synthesis
- Complex Molecules
- NJ - NZ
- Inhibitors
