Carbinoxaminhydrogenmaleat

Carbinoxaminhydrogenmaleat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R25:Giftig beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Beschreibung

Carbinoxamine is a competitive histamine H₁ receptor antagonist (K_i = 2.3 nM) and first generation antihistamine. It also competes with [³H]diltiazem, an L-type calcium channel blocker, for binding to the benzothiazepine site on rat cardiomyocytes (K_i = 1.08 nM). Carbinoxamine decreases negative inotropic activity in isolated guinea pig left atria by 76% (EC₅₀ = 250 nM) and negative chronotropic activity in guinea pig spontaneously beating isolated right atria (EC₅₀s = 250 and 480 nM, respectively) by 48% compared with control. Formulations containing carbinoxamine have been used in the treatment of allergic rhinitis.

Chemische Eigenschaften

Off-White Solid

Verwenden

Analgesic and anti-inflammatory compound

Definition

ChEBI: The maleic acid salt of carbinoxamine. An ethanolamine-type antihistamine, used for treating hay fever, as well as mild cases of Parkinson's disease.

Allgemeine Beschreibung

Carbinoxamine is availableas a bitter bimaleate salt, (d, l)-2-[p-chloro- -[2-(dimethylamino)ethoxy]benzyl]pyridine bimaleate (Clistin), which isa white crystalline powder that is very soluble in water andfreely soluble in alcohol and in chloroform. The pH of a 1%solution is between 4.6 and 5.1.
Carbinoxamine is a potent antihistaminic and is availableas the racemic mixture. It differs structurally from chlorpheniramineonly in having an oxygen atom separate theasymmetric carbon atom from the aminoethyl side chain. Themore active levo isomer of carbinoxamine has the (S) absoluteconfiguration and can be superimposed on the moreactive dextro isomer (S configuration) of chlorpheniramine.

Carbinoxaminhydrogenmaleat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Carbinoxaminhydrogenmaleat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	994	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3632	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12468	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	mcbio_sales@163.com	China	2255	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9358	58

3505-38-2(Carbinoxaminhydrogenmaleat)Verwandte Suche:

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• 2-((4-chlorophenyl)-2-pyridinylmethoxy)-n,n-dimethyl-ethanamin(z)-2-bute
• 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridinebimaleate
• 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridinemaleate
• 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)-pyridinmaleate(1:1)
• 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-n,n-dimethyl-ethanamin(z)-2-butene
• allergefonmaleate
• ciberon
• clistin
• clistinemaleate
• clistinmaleate
• hislosine
• lergefin
• p-carbinoxaminemaleate
• carbinoxamine hydrogen maleate
• N-[2-[(4-Chlorophenyl)(2-pyridinyl)methoxy]ethyl]-N,N-dimethylamine maleate salt
• Carbinoxamine Meleate
• CarbinoxaMine Maleate Salt, USP
• Carbinoxamine Maleate (200 mg)
• CarbinoxaMine 
• Maleate 
• arbinoxaMine Maleate
• {2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl}dimethylamine maleate
• CARBINOXAMINE MALEATE
• CARBINOXAMINE MALEATE SALT
• Allergefon
• 2-[(4-Clorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-ethanamine Maleate Salt
• 2-[(4-chlorophenyl)-(2-pyridyl)methoxy]ethyl-dimethyl-amine
• 2-[(4-chlorophenyl)-(2-pyridyl)methoxy]-N,N-dimethylethanamine
• 2-[(4-chlorophenyl)-(2-pyridyl)methoxy]-N,N-dimethyl-ethanamine
• 2-[(4-chlorophenyl)-pyridin-2-yl-methoxy]-N,N-dimethyl-ethanamine
• 2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine
• Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
• Carbinoxamine Maleates
• Carbinoxamine Maleate >
• But-2-enedioic acid (2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl)dimethylamine
• CARBINOXAMINE MALEATE SALT USP/EP/BP
• "(+/-)-Carbinoxamine D6 Maleate (N,N-dimethyl-d6)"
• Carbinoxamine Maleate (1096000)
• Carbinoxamine Maleate, ≥ 98.0%
• 3505-38-2
• C16H19ClN2OC4H4O4
• C17H22N2OC4H4O4
• C20H23ClN2O5
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