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Tributylphosphat Produkt Beschreibung

Tributyl phosphate Struktur
126-73-8
CAS-Nr.
126-73-8
Bezeichnung:
Tributylphosphat
Englisch Name:
Tributyl phosphate
Synonyma:
TBP;mcs2495;tributyl;Tributyle;ANTIFOAM T;celluphos4;Celluphos 4;Phos-Ad 100;disflamolltb;Kronitex TBP
CBNumber:
CB4187323
Summenformel:
C12H27O4P
Molgewicht:
266.31
MOL-Datei:
126-73-8.mol

Tributylphosphat Eigenschaften

Schmelzpunkt:
-79 °C
Siedepunkt:
289 °C
Dichte
0.979 g/mL at 25 °C(lit.)
Dampfdichte
9.2 (vs air)
Dampfdruck
27 mm Hg ( 178 °C)
Brechungsindex
n20/D 1.424(lit.)
Flammpunkt:
380 °F
storage temp. 
Store below +30°C.
Löslichkeit
water: soluble1ml in 165ml water
Aggregatzustand
Liquid
Farbe
Clear
Wasserlöslichkeit
0.6 g/100 mL
Merck 
14,9618
BRN 
1710584
Expositionsgrenzwerte
TLV-TWA 2.18 mg/m3 (0.2 ppm) (ACGIH), 5 mg/m3 (OSHA and NIOSH); IDLH 1300 mg/m3 (120 ppm) (NIOSH).
Stabilität:
Stable. Combustible. Incompatible with strong oxidizing agents. May be water sensitive.
CAS Datenbank
126-73-8(CAS DataBase Reference)
NIST chemische Informationen
Tri-n-butylphosphate(126-73-8)
EPA chemische Informationen
Phosphoric acid tributyl ester(126-73-8)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,F
R-Sätze: 22-38-40-62-48/20-36/37/38-11-20/22
S-Sätze: 36/37-46-45-36/37/39-16-53
RIDADR  UN 1208 3/PG 2
WGK Germany  2
RTECS-Nr. TC7700000
Selbstentzündungstemperatur 770 °F
TSCA  Yes
HS Code  29190010
Giftige Stoffe Daten 126-73-8(Hazardous Substances Data)
Toxizität LD50 orally in rats: 3.0 g/kg (Smyth, Carpenter)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung P264, P280, P302+P352, P321,P332+P313, P362
H351 Kann vermutlich Krebs verursachen. Karzinogenität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H412 Schädlich für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gewässergefährdend Kategorie 3 P273, P501
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P315 Sofort ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

Tributylphosphat Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD

FARBLOSE, GERUCHLOSE, VISKOSE FLüSSIGKEIT.

CHEMISCHE GEFAHREN

Zersetzung beim Verbrennen unter Bildung giftiger Rauche mit Phosphoroxiden.

ARBEITSPLATZGRENZWERTE

TLV: 0.2 ppm (als TWA); BEI vorhanden; (ACGIH 2005).
MAK: 1 ppm (als TWA); Hautresorption; Spitzenbegrenzung: überschreitungsfaktor II(4); Krebserzeugend Kategorie 4; Schwangerschaft: Gruppe C; (DFG 2005).

AUFNAHMEWEGE

Aufnahme in den Körper durch Inhalation der Dämpfe, über die Haut und durch Verschlucken.

INHALATIONSGEFAHREN

Beim Verdampfen bei 20°C tritt eine gesundheitsschädliche Kontamination der Luft nicht oder nur sehr langsam ein , viel schneller jedoch beim Versprühen oder Dispergieren.

WIRKUNGEN BEI KURZZEITEXPOSITION

WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt stark die Augen, die Haut und die Atemwege.

WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

Beim Verschlucken sind Auswirkungen auf die Blase mit nachfolgenden Gewebeschädenmöglich .

LECKAGE

Persönliche Schutzausrüstung: Atemschutzfilter für organische Gase und Dämpfe. NICHT in die Umwelt gelangen lassen. Ausgelaufene Flüssigkeit in abdichtbaren Behältern sammeln. Keine Kunststoffbehälter benutzen. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen.

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R38:Reizt die Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R62:Kann möglicherweise die Fortpflanzungsfähigkeit beeinträchtigen.
R48/20:Gesundheitsschädlich: Gefahr ernster Gesundheitsschäden bei längerer Exposition durch Einatmen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R11:Leichtentzündlich.

S-Sätze Betriebsanweisung:

S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S46:Bei Verschlucken sofort ärztlichen Rat einholen und Verpackung oder Etikett vorzeigen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S16:Von Zündquellen fernhalten - Nicht rauchen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.

Beschreibung

On decomposition, TBP releases COx, toxic fumes of phosphoric acid, phosphorus oxides, and/or phosphine. TBP is incompatible with strong oxidising agents and alkalis. The major uses of TBP in industry are as a component of aircraft hydraulic fluid and as a solvent for rare earth extraction and purification. Minor uses of TBP include use as a defoamer additive in cement casings for oil wells, an anti-air entrainment additive for coatings and floor finishes, as well as a carrier for fluorescent dyes. The major uses of TBP comprise over 80% of the volume produced.

Chemische Eigenschaften

Stable, colorless liquid; odorless. Miscible with most solvents and diluents; soluble in water. Combustible.

Physikalische Eigenschaften

Clear, colorless to pale yellow, odorless, slightly flammable, oily liquid

Verwenden

Tributyl phosphate is used as a plasticizer for cellulose esters, vinyl resins, and lacquers; and in making fireretardants, biocides, defoamers, and catalysts.

Verwenden

Extractant for metal complexes.1

Verwenden

Plasticizer for cellulose esters, lacquers, plastics, and vinyl resins.

Definition

ChEBI: A trialkyl phosphate that is the tributyl ester of phosphoric acid.

Vorbereitung Methode

Prepared by the reaction of phosphorus oxychloride with butyl alcohol.

Air & Water Reaktionen

Water insoluble. Reacts slowly with water under basic conditions.

Reaktivität anzeigen

Tributyl phosphate is incompatible with strong oxidizing agents and strong bases. Attacks some forms of plastics and rubber .

Health Hazard

Toxic by ingestion and inhalation, irritant to skin, bladder, eye and upper respiratory tract. May cause stimulation of the central nervous system.

Health Hazard

Acute
Non-industrial:
There are no data on the toxicity of TBP to man. The TLV is established by the American Council of Governmental Industrial Hygienists on the basis of analogy with triphenyl phosphate with which it bears some similarities in its toxic properties (ACGIH 1986).
Industrial:
A personal communication to ACGIH notes that workers exposed to 15 mg/m3 of TBP have complained of nausea and headache (ACGIH 1986). There are no other documented reports of deleterious effects of TBP in industrial situations.
Chronic
Inhibition of human erythrocyte and plasma cholinesterase is reported to be weak, even in vitro (Hayes and Sabine 1952; Sandmeyer and Kirwin 1981).

Health Hazard

Tributyl phosphate is a neurotoxic compound and an irritant. The toxic effects are characteristic of organic phosphates. It inhibits cholinesterase activity and causes paralysis. Inaddition,itcancausedepressionofthecentralnervoussystem,aswellasirritationofthe skin,eyes,andrespiratorypassage.Inhalation toxicity data in the literature are inconsistent.
The oral toxicity in rats was low; the LD50 value was reported as 1189 mg/kg (NIOSH 1986).
The pure liquid instilled into rabbits’ eyes caused severe irritation but no permanent damage. The irritation effect on the skin is mild.
Tributyl phosphate exhibited teratogenic effects in rats. There is no report on its carcinogenicity..

Brandgefahr

Special Hazards of Combustion Products: Toxic fumes of PO x

Industrielle Verwendung

1. As an antifoaming agent.
2. As a plasticizer for cellulose esters, lacquers, plastics, and vinyl resins.
3. As a complexing agent in the extraction of heavy metals, especially for the extraction of metal ions from solutions of reactor products in nuclear fuel reprocessing.
4. As an aircraft hydraulic fluid.
5. As a heat exchange medium and dielectric.
6. As a pigment-grinding agent.

Sicherheitsprofil

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion, inhalation, and subcutaneous routes. Experimental reproductive effects. A skin, eye, and mucous membrane irritant. Combustible when exposed to heat or flame. To fight fire, use CO2, dry chemical, fog, mist. When heated to decomposition it emits toxic fumes of POx.

Environmental Fate

Biological. Indigenous microbes in Mississippi River water degraded tributyl phosphate to carbon dioxide. After 4 wk, 90.8% of the theoretical carbon dioxide had evolved (Saeger et al., 1979).
Chemical/Physical. Complete hydrolysis yields 1-butanol and phosphoric acid via the intermediates dibutyl phosphate and monobutyl phosphate (Thomas and Macaskie, 1996).

Stoffwechsel

A system was developed utilizing isolated anterior forearm stratum corneum conjunctum of man to study skin penetrating capacity of a series of organic phosphates. TBP was tested in the system and was among the least penetrating of the compounds tested, only phosphoric acid and tri-o-cresyl phosphate penetrating less well. The value given was μmoles/cm2/min as the average maximum steady-state rate of penetration. In a comparative study with 3 living subjects, penetration was essentially the same as in the isolated skin preparation (Marzulli et al 1965).
Rats given a single oral dose of [14C]-labeled TBP at 14 mg/kg excreted 50, 10, and 6% of the administered dose in the urine, exhaled air, and feces, respectively, within 24 h. A single intraperitoneal dose at the same rate resulted in 70,7, and 4% of the administered dose in the urine, exhaled air, and feces within the first 24 h (Suzuki et al 1984).
Single oral administration of TBP to rats at 156 mg/kg led to its appearance in all the tissues in the first 30 min. The major amount was in the gastrointestinal tract where it was poorly absorbed and was rapidly eliminated. The total level of TBP in all other organs and tissues was 5.73%, but none was detected after 3 d (Khalturin and Andryushkeeva 1986).
A single i.p. dose of TBP at 250 mg/kg to rats resulted in 11 phosphoruscontaining metabolites in the urine within 24 h. The principal metabolic pathway resulted in stepwise debutylation, through hydroxylated intermediates, to give dibutyl hydrogen phosphate and butyl dihydrogen phosphate. Butyl bis(3-hydroxybutyl) phosphate and small amounts of monohydroxylated butyl derivatives also were isolated. Several metabolites, presumably resulting from omegaoxidation of the ?-butyl moieties to give butyric acid derivatives, also were detected, the result of a secondary pathway. In addition, butyl 2-hydroxybutyl hydrogen phosphate was isolated and characterized. The administration of a possible intermediate, dibutyl 3-oxobutyl phosphate, gave a metabolic profile similar to that of dibutyl 3-hydroxybutyl phosphate, the major metabolite, thus supporting the view that this compound was on the major metabolic pathway. Separate direct administration of various hydroxylated metabolites supported the metabolic pathways proposed (Suzuki et al 1984).
Rat liver microsomal preparations also metabolized TBP to mono- and dihydroxylated intermediates, giving dibutyl hydrogen phosphate as the terminal metabolite (Sasaki et al 1984). Microsomal preparations from goldfish liver and killifish also resulted in dibutyl 3-hydroxybutyl phosphate and dibutyl hydrogen phosphate (Sasaki et al 1985).

läuterung methode

The main contaminants in commercial samples are organic pyrophosphates, monoand dibutyl phosphates and butanol. It is purified by washing successively with 0.2M HNO3 (three times), 0.2M NaOH (three times) and water (three times), then fractionally distilled under vacuum. [Yoshida J Inorg Nucl Chem 24 1257 1962.] It has also been purified via its uranyl nitrate addition compound, obtained by saturating the crude phosphate with uranyl nitrate. This compound is crystallised three times from n-hexane by cooling to -40o, and then decomposed by washing with Na2CO3 and water. Hexane is removed by steam distillation; the water is then evaporated under reduced pressure, and the residue is distilled under reduced pressure. [Siddall & Dukes J Am Chem Soc 81 790 1959.] Alternatively, wash it with water, then with 1% NaOH or 5% Na2CO3 for several hours, then finally with water. Dry it under reduced pressure and fractionate it carefully under vacuum. It is a stable colourless oil, sparingly soluble in H2O (1mL dissolves in 165mL of H2O), but freely miscible in organic solvents. [Kuivila & Masterton J Am Chem Soc 74 4953 1952, Cox & Westheimer J Am Chem Soc 80 5441 1958, 31P NMR: Van Wazer J Am Chem Soc 78 5715 1956, Fertig et al. J Chem Soc 1488 1957, Beilstein 1 IV 1531.]

Waste disposal

Tributyl phosphate is dissolved in a combustible solvent and is burned in a chemical incinerator equipped with an afterburner and scrubber.

Tributylphosphat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Tributylphosphat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 300)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Springchem New Material Technology Co.,Limited
86-21-51752791
86-21-51752789 info@spring-chem.com China 1608 57
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21752 58
Hangzhou Bayee Chemical Co., Ltd.
0086-571-86990109; 0086-18605816692
0086-571-85775919 rachelhoo@bayeechem.com China 98 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
Speranza Chemical Co., Ltd.
+8618688942810
+86-755-33122716 sophieliu@speranzachem.com CHINA 258 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1856 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1017 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
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career henan chemical co
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126-73-8(Tributylphosphat)Verwandte Suche:


  • ANTIFOAM T
  • TBP
  • N-BUTYL-O-PHOSPHORIC ACID
  • N-BUTYL PHOSPHATE
  • N-TRIBUTYL PHOSPHATE
  • PHOSPHORIC ACID TRIBUTYL ESTER
  • PHOSPHORIC ACID TRI-N-BUTYL ESTER
  • Butyl phosphate, ((BuO)3PO)
  • Butyl phosphate, tri-
  • Celluphos 4
  • celluphos4
  • Disflamoll TB
  • disflamolltb
  • Kronitex TBP
  • mcs2495
  • Phos-Ad 100
  • phosphatedetributyle
  • Syn-O-Ad 8412
  • Tributilfosfato
  • Tributoxyphosphine oxide
  • tributoxyphosphineoxide
  • tributyl
  • Tributyl ester of phosphoric acid
  • Tributyle
  • Tributyle(phosphate de)
  • tributyle(phosphatede)
  • tributyle(phosphatede)(french)
  • Tributylfosfaat
  • Tributylfosfat
  • Tributylphosphat
  • tri-butylphosphat
  • tributylphosphate(tbp)
  • Tributylphsophate
  • TRIBUTYL PHOSPHATE
  • TRI-N-BUTYL ORTHOPHOSPHATE
  • TRI-N-BUTYL PHOSPHATE
  • Tributyl Phosphsate
  • TRIBUTYL PHOSPHATE, FOR EXTRACTION ANALY SIS
  • TRIBUTYL PHOSPHATE, 99+%
  • TRIBUTYL PHOSPHATE GC STANDARD
  • TributylPhosphate,Certified
  • TRIBUTYL PHOSPHATE, 98+%
  • tributylphospate
  • Phosphorsuretri-n-butylester
  • TRIBUTYL PHOSPHATE, 98+%TRIBUTYL PHOSPHATE, 98+%TRIBUTYL PHOSPHATE, 98+%
  • AURORA KA-1641
  • BUTYL PHOSPHATE
  • O,O,O-Tributylphosphate
  • TRIBUTYLPHOSPHATE extrapure
  • Nitrogen-Oxygen free radical piperidycol
  • Phosphoric acid tributyl
  • Tributyl phosphate 5g [126-73-8]
  • Tributyl phosphate 10g [126-73-8]
  • Tributyl phosphate, 99+% 1LT
  • Tributyl phosphate puriss., >=99.0% (GC)
  • Tributylphosph
  • Tributyl phosphate, 99%, analytical grade
  • Tributyl phosphate, Tri-n-butyl phosphate, Butyl phosphate,Phosphoric acid tri-n-butyl ester
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