4-Bromo-2-hydroxybenzoic acid
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- CAS-Nr.
- 1666-28-0
- Englisch Name:
- 4-Bromo-2-hydroxybenzoic acid
- Synonyma:
- NSC 109120;4-BROMOSALICYLIC ACID;4-Bromosalicyclic acid;4-Bromosalicylic acid, >=98%;2-Hydroxy-4-bromobenzoicacid;4-bromo-2-hydoxybenzoic acid;4-BROMO-2-HYDROXYBENZOIC ACID;VLOOKUP(C4,[1]Export!$D:$H,5,0);Benzoicacid, 4-bromo-2-hydroxy-;4-Bromo-2-hydroxybenzoic acid 98%
- CBNumber:
- CB4196824
- Summenformel:
- C7H5BrO3
- Molgewicht:
- 217.02
- MOL-Datei:
- 1666-28-0.mol
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4-Bromo-2-hydroxybenzoic acid Eigenschaften
- Schmelzpunkt:
- 164-165°C
- Siedepunkt:
- 330.2±32.0 °C(Predicted)
- Dichte
- 1.861±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.71±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- Orange
- InChI
- InChI=1S/C7H5BrO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,(H,10,11)
- InChIKey
- FYAKLZKQJDBBKW-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(Br)C=C1O
- CAS Datenbank
- 1666-28-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xi,Xn |
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| R-Sätze: |
22-52/53 |
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| S-Sätze: |
22-24/25-61 |
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| RIDADR |
2811 |
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| WGK Germany |
3 |
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| HazardClass |
IRRITANT |
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| PackingGroup |
Ⅲ |
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| HS Code |
2918290090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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4-Bromo-2-hydroxybenzoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
4-Bromo-2-hydroxybenzoic acid is a solid at normal temperature and pressure. It is stable at normal temperature and decomposes into phenol and carbon dioxide after rapid heating. It has some acidic properties.
Synthese
Under nitrogen atmosphere, add copper (II) bromide (8.8 g, 39.4 mmol, 1.2 equivalents), acetonitrile (50 ml), and 4-aminosalicylic acid (5.1 g, 49.5 mmol) to the vacuum-dried reaction flask, 1.5 equivalent). The reaction mixture was cooled to 0°C, and 2-hydroxy-4-bromobenzoic acid precursor (5.0 g, 32.6 mmol, 1.0 equiv) was added portion-wise. Additional acetonitrile (25 mL) was added to the mixture and stirred at 0 °C for 2 h. The organic extracts were combined and washed with 20% aqueous hydrochloric acid, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was dissolved in diethyl ether, and the resulting solution was extracted with 15% sodium hydroxide aqueous solution. The aqueous solution was washed with diethyl ether, acidified to pH 1 with 6N hydrochloric acid aqueous solution, and the mixture was extracted with diethyl ether. The combined organic extracts were washed with brine, dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was treated with chloroform, and the precipitate collected by filtration was 4-Bromo-2-hydroxybenzoic acid.
4-Bromo-2-hydroxybenzoic acid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-Bromo-2-hydroxybenzoic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 249)Lieferanten
1666-28-0()Verwandte Suche:
- 4-BROMOSALICYLIC ACID
- 4-BROMO-2-HYDROXYBENZOIC ACID
- 4-Bromo-2-Hydroxybenzoic Acid 2-Hydroxy-4-Bromobenzoic Acid
- 2-Hydroxy-4-bromobenzoicacid
- 4-Bromo-2-hydroxybenzoic acid 98%
- 4-Bromosalicyclic acid
- 4-Bromosalicylic acid, 5-Bromo-2-carboxyphenol
- 4-Bromosalicylic acid, >=98%
- NSC 109120
- Benzoicacid, 4-bromo-2-hydroxy-
- VLOOKUP(C4,[1]Export!$D:$H,5,0)
- 4-bromo-2-hydoxybenzoic acid
- 4-bromo-2-hydroxybenzoic acid/4-bromosalicylic acid
- 1666-28-0
- C7H5O3Br
- Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
- Benzoic acid
- Acids & Esters
- Bromine Compounds
