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Tunicamycin Produkt Beschreibung

TUNICAMYCIN Struktur
11089-65-9
CAS-Nr.
11089-65-9
Bezeichnung:
Tunicamycin
Englisch Name:
TUNICAMYCIN
Synonyma:
Nsc177382;Aids010655;Aids-010655;TUNICAMYCIN;TunicaMycin coMplex;InSolution? Tunicamycin,;Tunicamycin (n= 8,9,10,11);Tunicamycin Streptomyces sp.;tunicamycin from streptomyces sp.;tunicamycin from A streptomyces species
CBNumber:
CB4211576
Summenformel:
C37H60N4O16
Molgewicht:
816.89
MOL-Datei:
11089-65-9.mol

Tunicamycin Eigenschaften

Schmelzpunkt:
234-235℃ (decomposition)
alpha 
D20 +52° (c = 0.5 in pyridine)
Flammpunkt:
87℃
storage temp. 
2-8°C
Löslichkeit
Soluble in methanol, ethanol, DMSO, or DMF
Aggregatzustand
White to off-white solid
Sensitive 
Moisture & Light Sensitive
BRN 
6888090
InChIKey
YJQCOFNZVFGCAF-WPTOCQRYSA-N
EPA chemische Informationen
Tunicamycin (11089-65-9)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher T+,T
R-Sätze: 28
S-Sätze: 28-37/39-45
RIDADR  UN 3462 6.1/PG 2
WGK Germany  3
RTECS-Nr. YO7980200
8-10-18-21
HazardClass  6.1(a)
PackingGroup  II
HS Code  29419090
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H227 Combustible liquid Flammable liquids Category 4 Warnung P210, P280, P370+P378, P403+P235,P501
H300 Lebensgefahr bei Verschlucken. Akute Toxizität oral Kategorie 2 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
H330 Lebensgefahr bei Einatmen. Akute Toxizität inhalativ Kategorie 1 Achtung P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H332 Gesundheitsschädlich bei Einatmen. Akute Toxizität inhalativ Kategorie 4 Warnung P261, P271, P304+P340, P312
H373 Kann die Organe schädigen bei längerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizität (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P320 Besondere Behandlung dringend erforderlich
P330 Mund ausspülen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P405 Unter Verschluss aufbewahren.

Tunicamycin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R28:Sehr giftig beim Verschlucken.

S-Sätze Betriebsanweisung:

S28:Bei Berührung mit der Haut sofort abwaschen mit viel . . . (vom Hersteller anzugeben).
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).

Chemische Eigenschaften

White solid

Verwenden

The tunicamycins are a family of lipophilic nucleosides with fatty acids conjugated to an aminoglycoside group. The complex comprises analogues, tunicamycins I to X. This composition is typical of other products less precisely described as tunicamycins A to D. The tunicamycins act by blocking the formation of N-glycoside linkages to proteins via inhibition of formation of dolichol monophosphate from N-acetylglucosamine-1-phosphate. Tunicamycin blocks the synthesis of all N-linked glycoproteins (N-glycans) and causes cell cycle arrest in G1 phase. Tunicamycins are broadly active against prokaryotes, eukaryotes and viruses.

Verwenden

The tunicamycins are a family of lipophilic nucleosides with fatty acids conjugated to an aminoglycoside group. The complex comprises the analogues, tunicamycins I to X. This composition is typical of other products less precisely described as tunicamycins A to D. The tunicamycins act by blocking the formation of N-glycoside linkages to proteins via inhibition of formation of dolichol monophosphate from N-acetylglucosamine-1-phosphate. Tunicamycin blocks the synthesis of all N-linked glycoproteins (N-glycans) and causes cell cycle arrest in G1 phase. Tunicamycins are broadly active against prokaryotes, eukaryotes and viruses.

Verwenden

As a tool in studying glycoproteins in a wide variety of biological systems.

Definition

ChEBI: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty aci linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.

läuterung methode

The components of this nucleotide antibiotic from Streptomyces sp. are purified by recrystallising 3 times from hot glass-distilled MeOH, and the white crystals are dissolved in 25% aqueous MeOH and separated on a Partisil ODS-10_ column (9.4 x 25 cm) [Magnum-9 Whatman] using a 260nm detector. The column is eluted with MeOH/H2O mixture adjusted to 1:4 (v/v) then to 2:4 (v/v). The individual components are recovered and lyophilised. Ten components have been isolated, and all were active (to varying extents) depending on the lengths of the aliphatic side-chains. The mixture has UV max at 205 and 260nm (A 1cm 230 and 110). It is stable in H2O at neutral pH but unstable in acidic solution. It inhibits protein glycosylation. [Mahoney & Duskin J Biol Chem 254 6572 1979, Elnein Trends Biochem Sci 6 219 1981, Takatsuki J Antibiot 24 215 1971.] Uracil, uridine and uridine nucleotides. These are resolved by ion-exchange chromatography with AG1 (Cl form). [Lindsay et al. Anal Biochem 24 506 1968.]

Tunicamycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Tunicamycin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 93)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Alfa Chemistry 1-201-478-8534
1-516-927-0118 inquiry@alfa-chemistry.com United States 9936 60
J & K SCIENTIFIC LTD. 010-82848833- ;010-82848833-
86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801
86-21-50328109 3bsc@sina.com China 15881 69
Ascent Scientific 4401179829988
4402030 700 369 customerservice@ascentscientific.co.uk United Kingdom 279 60
Chengdu XiYa Chemical Technology Co., Ltd.
028-84752058 sale@xiyashiji.com China 9627 57
BOC Sciences
info@bocsci.com United States 10506 65
Dalian Meilun Biotech Co., Ltd. 0411-66771943- ;0411-66771942
0411-66771945 sales@meilune.com;sales@meilune.com; China 4008 58
ShangHai YuanYe Biotechnology Co., Ltd. 021-61312847-
021-55068248 2797782341@qq.com China 4976 60
Shanghai T&W Pharmaceutical Co., Ltd. +86 21 61551611
+86 21 50676805 contact@trustwe.com China 9920 58
Cheng Du Micxy Chemical Co.,Ltd 028-85632863-
028-85632863 sales@micxy.com; China 13070 58

11089-65-9(Tunicamycin)Verwandte Suche:


  • InSolution Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem
  • Aids010655
  • Aids-010655
  • Nsc177382
  • TunicaMycin froM StreptoMyces lysosuperficus
  • TunicaMycin coMplex
  • InSolution? Tunicamycin,
  • TUNICAMYCIN, STREPTOMYCES IYSOSUPERFICUS
  • TUNICAMYCIN, STREPTOMYCES LYSOSUPERFICUS
  • TUNICAMYCIN
  • tunicamycin from A streptomyces species
  • tunicamycin from streptomyces lysosuperificus
  • Tunicamycin Streptomyces sp.
  • TUNICAMYCIN FROM STREPTOMYCES LYSOSUPERFIUS NOV. SP.
  • Tunicamycin from Streptomyces chartreusis
  • tunicamycin from streptomyces sp.
  • Tunicamycin (n= 8,9,10,11)
  • 11089-65-9
  • C39H64N4O16tunicamycinCn10
  • C25H38N4O16
  • BioChemical
  • Antibiotics T-Z
  • Antibiotics
  • Antibiotics A to Z
  • Antibacterial
  • Antibiotics
  • Antibiotics A to
  • Antibiotics by Application
  • Antibiotics T-ZAntibiotics
  • AntifungalAntibiotics
  • Antineoplastic and Immunosuppressive AntibioticsAntibiotics
  • AntiviralAntibiotics
  • Chemical Structure Class
  • Interferes with Protein SynthesisSpectrum of Activity
  • L - ZAntibiotics
  • Mechanism of Action
  • Spectrum of Activity
  • Signalling
  • antibiotic
  • NucleosidesMore...Close...
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