Rupatadine Fumarate

Rupatadine Fumarate Struktur
182349-12-8
CAS-Nr.
182349-12-8
Englisch Name:
Rupatadine Fumarate
Synonyma:
Ralif;Rupax FuMarate;Rupafin FuMarate;Pafinur FuMarate;UR12592 Fumarate;Rinialer FuMarate;UR 12592 Fumarate;UR-12592 Fumarate;Rupatadin Fumarate;RUPATADINE FUMARATE
CBNumber:
CB42131159
Summenformel:
C26H26ClN3.C4H4O4
Molgewicht:
532.03
MOL-Datei:
182349-12-8.mol

Rupatadine Fumarate Eigenschaften

Schmelzpunkt:
196-198°C
storage temp. 
Sealed in dry,2-8°C
Löslichkeit
Methanol (Slightly, Heated)
Aggregatzustand
Solid
Farbe
White to Pale Brown
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Rupatadine Fumarate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Rupatadine fumarate, a novel antiallergic drug with a dual mechanism of action, was introduced in Spain as an oral treatment for perennial and seasonal rhinitis. Rupatadine acts as non-sedating histamine H1 receptor antagonist and plateletactivating factor (PAF) antagonist. Its Kiapp i values against [3H]WEB-2086 binding to rabbit platelet membrane PAF receptors and [3H]pyralimine binding to guinea pig cerebellum membrane H1 histamine receptors are 0.55 and 0.10 μM, respectively. It has a rapid onset of action, with patients experiencing relief of symptoms within 2 h, and its long duration of action (>24 h) permits once-daily dosing. Rupatidine is prepared in a 6-step convergent synthesis, with the key steps involving the Grignard reaction of a N-alkyl-4-chloropiperdine with a benzocycloheptapyridinone intermediate, followed by dehydration. Rupatadine is rapidly absorbed after oral administration. The time to reach maximum plasma concentration is 0.75–1 h and the mean half-life in healthy volunteers is ~6 h. It is extensively metabolized, mainly by CYP3A4, and the major elimination route for the drug is biliary excretion. In comparative clinical trials, rupatadine 10 mg once daily was as effective as certizine 10 mg in short-term studies (2–4 weeks duration), but provided a better profile of CNS side effects. In comparison with ebastine 10 mg and loratadine 10 mg, rupatadine showed a superior relief of rhinitis symptoms at the same dose. Rupatadine was well tolerated in clinical trials and, at the recommended daily dose of 10 mg, was free of the sedative effects associated with first-generation antihistamines. In addition, there were no significant differences in the overall incidence of adverse events in rupatidine-treated patients and those treated with placebo or standard reference products.

Chemische Eigenschaften

Rupatadine fumarate is white or off-white color crystalline powder, odorless, and mildly bitter flavor, slightly draws moistly, in methanol, dissolves, almost insoluble in water, slightly molten in 0.1mol/L hydrochloric acid solution.

Verwenden

8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidylidene]-5H-benzo[5,6]cyclohepta[1,2-b]pyridine fumarate is a dual antagonist of histamine H1 and platelet-activating factor receptors. Rupatadine is used as an antihistaminic.

Rupatadine Fumarate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Rupatadine Fumarate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 228)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
HAINAN POLY PHARMCEUTICAL CO. LTD
+86-0571-89385087 +8613616530509
ff@hnpoly.com China 118 58
Shanghai Affida new material science and technology center
+undefined15081010295
2691956269@qq.com China 359 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21691 55
Chembon Pharmaceutical Co., Ltd.
+86-28-8425-2981
CHINA 724 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
Shandong chuangyingchemical Co., Ltd.
18853181302
sale@chuangyingchem.com CHINA 5909 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873
sales@chemdad.com China 39916 58

182349-12-8()Verwandte Suche:


  • Rupafin FuMarate
  • Rupax FuMarate
  • 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-, (2E)-2-butenedioate (1:1)
  • RUPATADINE FUMARATE
  • 8-chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridyl)methyl]-4-piperidylidene]-5h-benzo[5,6]cyclohepta[1,2-b]pyridine fumarate
  • Alergoliber FuMarate
  • Pafinur FuMarate
  • Rinialer FuMarate
  • Rupatadin Fumarate
  • Rupatadine Fumarate USP/EP/BP
  • 8-Chloro-11-(1-((5-methylpyridin-3-yl)methyl)piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine fumarate
  • Rupatadine Fumarate (UR-12592)
  • Rupatadine FumarateQ: What is Rupatadine Fumarate Q: What is the CAS Number of Rupatadine Fumarate Q: What is the storage condition of Rupatadine Fumarate Q: What are the applications of Rupatadine Fumarate
  • 17alpha-Epoxypregnenolone acetate
  • 17-Epoxypregnenolone acetate
  • 8-Chloro-6,11-dihydro-11-[1-[(5-methyl-3-pyridinyl)methyl]-4-piperidinylidene]-5H-benzo[5,6]cyclohepta[1,2-b]pyridine fumarate
  • Rupatadine Fumaric Acid
  • 13-chloro-2-{1-[(5-methylpyridin-3-yl)methyl]piperidin-4-ylidene}-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(15),3,5,7,11,13-hexaene
  • Rupatadine Fumarate IP
  • Naringenin Impurity 19
  • Ralif
  • UR 12592 Fumarate
  • UR12592 Fumarate
  • UR-12592 Fumarate
  • 182349-12-8
  • Inhibitors
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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