AMG-51

890019-63-3

CAS-Nr.: 890019-63-3

Englisch Name:: AMG-51

Synonyma:: AMG-51;AMG-51 (KRC547);2-(4-fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-one;5-[3-Fluoro-4-[[6-Methoxy-7-(3-Morpholinopropoxy)quinolin-4-yl]oxy]phenyl]-2-(4-fluorophenylaMino)-3-MethylpyriMidin-4(3H)-one;4(3H)-Pyrimidinone, 5-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-2-[(4-fluorophenyl)amino]-3-methyl-

CBNumber:: CB42621126

Summenformel:: C34H33F2N5O5

Molgewicht:: 629.65

MOL-Datei:: 890019-63-3.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 10

AMG-51 Eigenschaften

Siedepunkt:: 739.7±70.0 °C(Predicted)

Dichte: 1.33±0.1 g/cm3(Predicted)

pka: 7.01±0.10(Predicted)

Sicherheit

AMG-51 Chemische Eigenschaften,Einsatz,Produktion Methoden

Enzyminhibitor

This protein kinase inhibitor (FW = 629.65 g/mol; CAS 890019-63-3; Solubility: 15 mM in DMSO), also known as 5-(3-fluoro-4-(6-methoxy-7- (3-morpholinopropoxy)quinolin-4-yloxy)phenyl)-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one, targets c-Met, or hepatocyte growth factor receptor (HGFR), a protein tyrosine kinase that plays a key role in several cellular processes and is overexpressed or mutated in different human cancers. AMG-51 shows the enzyme selectivity of c-Met with a (Ki = 4.9 nM), with off-targets, such as IGFR (Ki = 22nM), Ron or Recepteur d'Origine Nantais kinase (Ki = 28nM), and KDR (Ki = 139 nM).

AMG-51 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

AMG-51 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 10)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
SYN\|thesis med chem P/L	+86-021-50720296	service@synkinase.com	China	266	58
Pharmacodia (Beijing) Co.,Ltd	+86-400-851-9921	sales@pharmacodia.com	China	2317	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Zhongshan Geometric Biological Technology Co., Ltd.	+86-13168912896		China	253	58
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58
Novachemistry	44-20819178-90 02081917890	info@novachemistry.com	United Kingdom	4381	58
Shanghai Biopharmaleader Co., Ltd.	+86 18721201413	sales@biopharmaleader.com	China	1720	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58

AMG-51
5-[3-Fluoro-4-[[6-Methoxy-7-(3-Morpholinopropoxy)quinolin-4-yl]oxy]phenyl]-2-(4-fluorophenylaMino)-3-MethylpyriMidin-4(3H)-one
2-(4-fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-one
AMG-51 (KRC547)
4(3H)-Pyrimidinone, 5-[3-fluoro-4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]phenyl]-2-[(4-fluorophenyl)amino]-3-methyl-
890019-63-3
C34H33F2N5O5