NSI-189 Phosphate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
NSI-189 phosphate (NSI-189) is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent.
Verwenden
NSI-189 is a novel oral drug which was developed by Neuralstem for the treatment of cognitive disorders. Now the drug is being tested in phase II of clinical trials in patients suffering from major depressive disorder. The mechanism of NSI-189 action is explained by its ability to stimulate the generation of new neurons in the hippocampus, however the exact target molecule is still unknown.
Biologische Funktion
NSI-189 is a neurogenic. It allows the brain to develop healthy brain cells at a quicker rate than usual, which means that people suffering from depression, mental disorders, or degenerative conditions might all benefit from using NSI-189. This compound has also been shown to possess an anti-stress effect.
Possesses antidepressant properties that may improve cognitive function, treat traumatic brain injury, Alzheimer's Disease (AD), Post-Traumatic Stress Disorder (PTSD), and stroke, and prevent cognitive and memory decline in aging.
NSI-189 can increase neurotrophic factors such as Stem Cell Factor (SCF), Brain-Derived Neurotrophic Factor (BDNF), Vascular Endothelial Growth Factor (VEGF), and Glial-Derived Neurotrophic Factor (GDNF).
NSI-189 may effectively treat MDD as well as other psychiatric disorders by increasing neurogenesis (growth) in the hippocampus.
NSI-189 is a benzylpiperizine-aminiopyridine, a novel chemical entity that stimulates neurogenesis of human hippocampus-derived neural stem cells.
NSI 189 is currently in research for treating other neurological disorders such as Alzheimer's disease, brain injury, stroke, traumatic stress disorder.
A rise in the energy levels, and increase libido, and sexual performance has been noted by some individuals.
NSI-189 may be able to protect nerves from toxicity in diabetes. It may help with nerve pain and neuropathy in diabetes.
Nebenwirkungen
Most of the clinical research on NSI 189 is on animals, and there are only very few on humans.
Nonetheless, patients'side effects are reported regardless of taking it in small or higher doses.
People who use the drug at 40 mg may still experience dry mouth, restlessness, sleepiness, headaches, dizziness, rash, hyperthermia, and palpitations.
There are no serious long term side effects reported on animals when administered in high doses.
Across all three doses, NSI-189 was well-tolerated with no serious adverse events.
The mean half-life of the drug was 17.4 to 20.5 hours, with steady-state reached after 96 to 120 hours.
NSI-189 Phosphate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
