5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine

5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine Struktur
1527503-11-2
CAS-Nr.
1527503-11-2
Englisch Name:
5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine
Synonyma:
A-336;A-366;CS-2077;A-366,MV4;A-366; A366;A 366;5'-methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine;5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine;Spiro[cyclobutane-1,3'-[3H]indol]-2'-amine, 5'-methoxy-6'-[3-(1-pyrrolidinyl)propoxy]-;11,selective,cells,peptide-competitive,epigenetics,Inhibitor,interaction,inhibit,H3K4me3,Epigenetic Reader Domain,leukemia,Histone Methyltransferase,methyltransferase
CBNumber:
CB43038523
Summenformel:
C19H27N3O2
Molgewicht:
329.44
MOL-Datei:
1527503-11-2.mol

5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine Eigenschaften

Siedepunkt:
533.6±60.0 °C(Predicted)
Dichte
1.29±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
DMSO : 50 mg/mL (151.77 mM; Need ultrasonic)
pka
10.18±0.20(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H400 Sehr giftig für Wasserorganismen. Kurzfristig (akut) gewässergefährdend Kategorie 1 Warnung P273, P391, P501
Sicherheit
P273 Freisetzung in die Umwelt vermeiden.
P391 Verschüttete Mengen aufnehmen.

5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

A-366 is an SGC chemical probe for G9a/GLP, developed in collaboration with Abbvie. A-366 is a potent, selective inhibitor of the histone methyltransferase G9a. The IC50 values for G9a inhbition in enzymatic and cell based assays are 3.3 and approximately 3 μM, respectively. A-366 has little or no detectable activity against a panel of 21 other methyltransferases. For full characterization details, please visit the A-366 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 63)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6313 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc.
+1-781-999-5354
support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8475 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 132020 58
DKMbiochem.Co. Ltd 15901859516
sales@DKMbiochem.com China 345 58
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652
sales@meilune.com China 4648 58

  • 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine
  • A-366
  • A-336
  • CS-2077
  • A-366; A366;A 366
  • 5'-methoxy-6'-(3-(pyrrolidin-1-yl)propoxy)spiro[cyclobutane-1,3'-indol]-2'-amine
  • Spiro[cyclobutane-1,3'-[3H]indol]-2'-amine, 5'-methoxy-6'-[3-(1-pyrrolidinyl)propoxy]-
  • 11,selective,cells,peptide-competitive,epigenetics,Inhibitor,interaction,inhibit,H3K4me3,Epigenetic Reader Domain,leukemia,Histone Methyltransferase,methyltransferase
  • A-366,MV4
  • 1527503-11-2
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