ChemicalBook
Chinese english Germany Japanese Korea

Dimenhydrinat Produkt Beschreibung

Dimenhydrinate Struktur
523-87-5
CAS-Nr.
523-87-5
Bezeichnung:
Dimenhydrinat
Englisch Name:
Dimenhydrinate
Synonyma:
emes;epha;DiMate;amosyt;dramyl;dromyl;emedyl;faston;gravol;vomexa
CBNumber:
CB4308768
Summenformel:
C17H21NO.C7H7ClN4O2
Molgewicht:
469.97
MOL-Datei:
523-87-5.mol

Dimenhydrinat Eigenschaften

Schmelzpunkt:
102-107°C
Dichte
1.2586 (rough estimate)
Brechungsindex
1.6500 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
Löslichkeit
Slightly soluble in water, freely soluble in ethanol (96 per cent).
Aggregatzustand
neat
Wasserlöslichkeit
Slightly soluble (0.1-1 g/100 mL at 22 ºC)
InChIKey
NFLLKCVHYJRNRH-UHFFFAOYSA-N
CAS Datenbank
523-87-5(CAS DataBase Reference)
EPA chemische Informationen
Dimenhydrinate (523-87-5)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn,Xi
R-Sätze: 22-61-36/37/38
S-Sätze: 22-26-36/37/39-53
WGK Germany  3
RTECS-Nr. XH5082000
TSCA  Yes
HS Code  2939590000
Giftige Stoffe Daten 523-87-5(Hazardous Substances Data)
Bildanzeige (GHS)
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P330 Mund ausspülen.

Dimenhydrinat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R22:Gesundheitsschädlich beim Verschlucken.
R61:Kann das Kind im Mutterleib schädigen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.

Beschreibung

Dimenhydrinate (16.1.2) is a complex compound of N, N-dimethyl (2- diphenylmethoxy)ethylamine—diphenhydramine with 8-chlorotheophylline. While blocking the H1 receptor, dimenhydrinate simultaneously acts on the vomiting center.

Chemische Eigenschaften

White Solid

Originator

Dramamine,Searle,US,1949

Verwenden

Dimenhydrinate is used for preventing and stopping sea or airsickness, and for nausea and vomiting. Synonyms of this drug are dramamine, dadalon, emedyl, travelin, and others.

Verwenden

An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).

Verwenden

Used for treating vertigo, motion sickness, and nausea associated with pregnancy

Definition

ChEBI: The diphenhydramine salt of 8-chlorotheophylline. Its effects are similar to those of diphenhydramine, but it is less potent. It was thought that by combining the antiemetic effects of diphenhydramine with the mild stimulant effects of 8-chlorotheophyline, the extreme drowsiness induced by the former would be mitigated. However, the sedation caused by diphenhydramine is considerably stronger than the stimulation caused by 8-chlorotheophylline. Dimenhydrinate is used mainly as an antiemetic in the prevention nd treatment of motion sickness.

Manufacturing Process

58.8 grams of 8-chlorotheophylline and 70 grams of β-dimethylaminoethyl benzohydryl ether are dissolved in 150 cc of hot methanol. Then 5 grams of activated charcoal are added and the mixture is boiled for an hour. It is filtered hot and the filtrate cooled. The crystalline precipitate of βdimethylaminoethyl benzohydryl ether 8-chlorotheophyllinate is collected on a filter, washed with ether and dried. It melts at 96-99°C. It is dissolved in boiling ethyl acetate, filtered hot to remove any insoluble material, and then chilled. The salt so obtained melts at 102.5°-104°C after filtration, washing with ether and drying.

Trademarks

Dommanate (Forest).

Therapeutic Function

Antinauseant

Allgemeine Beschreibung

The 8-chlorotheophyllinate (theoclate) salt of diphenhydramine, 8-chlorotheophylline 2-(diphenylmethoxy)-N,N-dimethylethylamine (Dramamine), is a white crystalline, odorless powder that is highly soluble in water and freely soluble in alcohol and chloroform. Dimenhydrinate is recommended for nausea of motion sickness and for hyperemesis gravidarum (nausea of pregnancy).

Allgemeine Beschreibung

Crystalline white powder.

Air & Water Reaktionen

Slightly soluble in water. Slightly acidic.

Health Hazard

SYMPTOMS: Symptoms associated with Dimenhydrinate include: drowsiness, lethargy, fatigue hypnosis and coma. Initial sedation may be followed by central nervous system hyperexcitability. Also, the victim may experience dry mouth, anorexia, nausea, vomiting, abdominal distress, constipation, and/or diarrhea.

Brandgefahr

Flash point data for Dimenhydrinate are not available but Dimenhydrinate is probably non-flammable.

Sicherheitsprofil

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. A drug much used for motion sickness. Human systemic effects by ingestion: arrhythmias, convulsions, distorted perceptions, hallucinations, intracranial pressure increase. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, and Cl-. See also AMINES.

Veterinary Drugs and Treatments

In veterinary medicine, dimenhydrinate is used primarily for its antiemetic effects for vomiting and in the prophylactic treatment of motion sickness in dogs and cats. Dimenhydrinate may be useful as an adjunctive treatment for feline pancreatitis. As dimenhydrinate is often thought of as “half-strength diphenhydramine” it can be employed whenever a histmine-1 blocker is desired.

Dimenhydrinat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Dimenhydrinat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 189)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3004 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1275 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
+86 15821988213 info@longyupharma.com China 2473 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47498 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29864 58

523-87-5(Dimenhydrinat)Verwandte Suche:


  • DRAMAMINE
  • DIMENHYDRINATE
  • THEOHYDRAMINE
  • N-[2-DIPHENYLMETHOXYETHYL]-N,N-DIMETHYLAMMONIUM 8-CHLORO-THEOPHYLLINATE
  • 2-(benzhydryloxy)-n,n-dimethylethylamine 8-chlorotheophyllinate
  • 8-chloro-3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dione compound with 2-(diphenylmethoxy)-n,n-dimethylethanamine (1:1)
  • 2-(benzhydryloxy)-n,n-dimethylethylaminecompd.with8-chlorotheophylline
  • 2-(diphenylmethoxy)-n,n-dimethylethylamine8-chlorotheophyllinate
  • 2-(diphenylmethyl)oxyethyl-dimethylammonium
  • 8-chloro-1,3-dimethyl-2-oxo-6-purinolate
  • Dimenhydrinate,Usp
  • 1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-1,3-dimethyl-, compd. with 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
  • DIMENHYDRINAT
  • DIMENHYDRATE
  • DIMENHYDRINATE[N-(2-DIPHENYLMETHOXYETHYL)-N,N-DIMETHYLAMMONIUM 8-CHLOROTHEOPHYLLINATE]
  • 8-Chlorotheophylline 2-(DiphenylMethoxy)-N,N-diMethylethylaMine
  • DiMate
  • DoMManate
  • DraMocen
  • Gravinol (antieMetic)
  • NSC 117855
  • Travel-GuM
  • 8-chloro-1,3-diMethyl-1H-purine-2,6(3H,7H)-dione coMpound with 2-(benzhydryloxy)-N,N-diMethylethanaMine (1:1)
  • Dimenhydrinate (200 mg)
  • 6-dione,8-chloro-3,7-dihydro-1,3-dimethyl-1h-purine-compd.with2-(dipheny
  • 6-dione,8-chloro-3,7-dihydro-1,3-dimethyl-1h-pyrine-compdwith2-(diphenyl
  • 8-chlorotheophylline,compd.with2-(diphenylmethoxy)-n,n-dimethylethylamine
  • amosyt
  • anautine
  • andramine
  • antemin
  • aviomarin
  • benzhydryl-beta-dimethylaminoethylether8-chlorotheophylline
  • beta-dimethylaminoethylbenzhydrylether1,3-dimethyl-8-chloroxanthine
  • chloranautine
  • diamarin
  • diphenhydramine8-chlorotheophyllinate
  • diphenhydramine8-chlorotheophylline
  • Diphenhydramineteoclate
  • diphenhydrinate
  • dramamin
  • dramarin
  • dramyl
  • dromyl
  • eldodram
  • emedyl
  • emes
  • epha
  • faston
  • gravinol
  • gravol
  • lmethoxy)-n,n-dimethylethanamine(1:1)
  • menhydrinate
  • methoxy)-n,n-dimethylethanamine(1:1)
  • n,n-dimethyl-2-(diphenylmethoxy)-ethylamincompd.with8-chlorotheophylli
  • n,n-dimethyl-2-diphenylmethoxyethylamine8-chlorotheophyllinate
  • nci-c60639
  • n-dimethyl-ethylamine2-(diphenylmethoxy)-compdwith8-chlorotheophylline(
Copyright 2019 © ChemicalBook. All rights reserved