Pifithrin-α, p-nitro, cyclic

Pifithrin-α, p-nitro, cyclic Struktur
60477-38-5
CAS-Nr.
60477-38-5
Englisch Name:
Pifithrin-α, p-nitro, cyclic
Synonyma:
PFN-α;p-Nitro-CyclicPifithrin-α;p-Nitro-Cyclic Pifithrin-a;Cyclic pifithrin-α-p-nitro;p-nitro-Cyclic Pifithrin-α;Cyclic pifithrin-α-p-nitro;Pifithrin-α, p-nitro, cyclic;Pifithrin-alpha, p-Nitro, Cyclic;p-nitro Cyclic Pifithrin-.alpha.;Pifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem
CBNumber:
CB43136760
Summenformel:
C15H13N3O2S
Molgewicht:
299.35
MOL-Datei:
60477-38-5.mol

Pifithrin-α, p-nitro, cyclic Eigenschaften

Schmelzpunkt:
233-234 °C(Solv: N,N-dimethylformamide (68-12-2); water (7732-18-5))
Dichte
1.53±0.1 g/cm3(Predicted)
storage temp. 
-20C
Löslichkeit
≤1mg/ml in dimethyl formamide
Aggregatzustand
Yellow solid
pka
6.14±0.20(Predicted)

Sicherheit

Pifithrin-α, p-nitro, cyclic Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

p-nitro-Cyclic Pifithrin-α is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptisis. Anti-cancer agent.

Allgemeine Beschreibung

A cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED50 = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t1/2 = 6h in neuron culture medium at 37°C) than Pifithrin-α (Cat. No. 506132). However, despite its in vitro efficacy, this inhibitor is not effective when adminstered in rats in vivo. For in vivo applications, please consider Pifithrin-α, p-Nitro (Cat. No. 506152).

Biochem/physiol Actions

Cell permeable: yes

Pifithrin-α, p-nitro, cyclic Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Pifithrin-α, p-nitro, cyclic Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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